Abstract: A method for communicating between a first network and a second network is described. The method includes receiving, by a network device via a persistent control channel established between the network device and a server device connected to a first network, a first message that includes: (1) information indicating a tunneling protocol, and (2) information associated with a first tunneling payload. The persistent control channel is for communicating: (1) messages including control information, and (2) messages including tunneling payloads. The method also includes transmitting, by the network device to an endpoint device connected to a second network, a second message including the information associated with the first tunneling payload.

Abstract: A method is described. The method includes receiving, by a network device via a persistent control channel established between the network device and a server device connected to a first network, a first message that includes: (1) information indicating a tunneling protocol, and (2) information associated with a first tunneling payload. The persistent control channel is for communicating: (1) messages including control information, and (2) messages including tunneling payloads. The method also includes transmitting, by the network device to an endpoint device connected to a second network, a second message including the information associated with the first tunneling payload.

Abstract: This disclosure relates to a combination therapy for treating patients suffering from a proliferative disease. More particularly, the disclosure relates to combination therapies comprising an AXL inhibitor, an immune checkpoint modulator (ICM), and a chemotherapeutic agent and/or radiotherapy for treating patients suffering from cancer, as well as compositions and methods for treating patients with said combination therapy.

Abstract: A method for communicating between a first network and a second network is described. The method includes receiving, by a network device via a persistent control channel established between the network device and a server device connected to a first network, a first message that includes: (1) information indicating a tunneling protocol, and (2) information associated with a first tunneling payload. The persistent control channel is for communicating: (1) messages including control information, and (2) messages including tunneling payloads. The method also includes transmitting, by the network device to an endpoint device connected to a second network, a second message including the information associated with the first tunneling payload.

Abstract: A method is described. The method includes receiving, by a network device via a persistent control channel established between the network device and a server device connected to a first network, a first message that includes: (1) information indicating a tunneling protocol, and (2) information associated with a first tunneling payload. The persistent control channel is for communicating: (1) messages including control information, and (2) messages including tunneling payloads. The method also includes transmitting, by the network device to an endpoint device connected to a second network, a second message including the information associated with the first tunneling payload.

Abstract: The invention relates to a method of selecting a subject for treatment with a combination of an AXL inhibitor (AXLi) and an immune checkpoint modulator (ICM), the method comprising: identifying subjects having an AXL-related disease characterised by the presence of cells having modified STK11 activity or expression; and, selecting thus identified subjects for treatment. The invention also relates to an AXL inhibitor (AXLi) and an immune checkpoint modulator (ICM) for use in the treatment of an AXL-related disease.

Abstract: The invention relates to the control of gene expression. Specifically, the invention provides compositions and methods for the production and use of recombinant nucleic acid molecules that have the ability to specifically downregulate an expressed target gene in vivo. In some aspects, the invention provides methods for producing a hairpin DNA molecule where part of the molecule is derived from an mRNA that is a target for a small interfering RNA (siRNA) derived from the hairpin. In other aspects, the invention provides synthetic hairpin adapter oligonucleotides that are used in the construction of siRNA-producing cassettes. In other aspects, the invention provides methods for testing for the presence or absence of specific inhibitory activity of an RNAi trigger molecule, and in still other aspects, the invention provides methods for identifying an active RNAi trigger molecule from a library of RNAi trigger molecules.

Abstract: The present disclosure is directed at a snowpack measurement device that is configurable between a skiing configuration, in which it can be used as a ski pole, and a snowpack measurement configuration, in which it can be used as a probe to measure one or more characteristics of a snowpack. In some embodiments, the device can wirelessly transmit snowpack measurement results, for example, to a user's mobile device. The device can house sensitive electronics and sensors for the snowpack measurement tool within a ski pole handle of the device when not in use.

Abstract: The present inventions relate generally to methods, apparatus and systems for measuring snow stability and structure which may be used to assess avalanche risk. The disclosed apparatus includes a sensing unit configured to sense a temperature of a layer of snow as the sensing unit is being driven into the layer of snow. The disclosed apparatus may also be configured to take other environmental measurements, including resistance to penetration, humidity, grain size, slope aspect and inclination. Methods and apparatus are also disclosed for generating a profile of snow layer temperature according to depth based on the sensed temperature. Systems and apparatus are also disclosed for sharing the generated profiles among a plurality of users via a central server, and for evaluating an avalanche risk at a geographic location.

Abstract: The present inventions relate generally to methods, apparatus and systems for measuring snow stability and structure which may be used to assess avalanche risk. The disclosed apparatus includes a sensing unit configured to sense a temperature of a layer of snow as the sensing unit is being driven into the layer of snow. The disclosed apparatus may also be configured to take other environmental measurements, including resistance to penetration, humidity, grain size, slope aspect and inclination. Methods and apparatus are also disclosed for generating a profile of snow layer temperature according to depth based on the sensed temperature. Systems and apparatus are also disclosed for sharing the generated profiles among a plurality of users via a central server, and for evaluating an avalanche risk at a geographic location.

Abstract: The present inventions relate generally to methods, apparatus and systems for measuring snow stability and structure which may be used to assess avalanche risk. The disclosed apparatus includes a sensing unit configured to sense a resistance to penetration as the sensing unit is being driven into a layer of snow. The disclosed apparatus may also be configured to take other environmental measurements, including temperature, humidity, grain size, slope aspect and inclination. Methods and apparatus are also disclosed for generating a profile of snow layer hardness according to depth based on the sensed resistance to penetration and identifying areas of concern which may indicate an avalanche risk. Systems and apparatus are also disclosed for sharing the generated profiles among a plurality of users via a central server, and for evaluating an avalanche risk at a geographic location.

Abstract: The present inventions relate generally to methods, apparatus and systems for measuring snow stability and structure which may be used to assess avalanche risk. The disclosed apparatus includes a sensing unit configured to measure a size of snow grains as the sensing unit is being driven into a layer of snow. The disclosed apparatus may also be configured to take other environmental measurements, including resistance to penetration, temperature, humidity, slope aspect and inclination. Methods and apparatus are also disclosed for generating a profile of snow grain size according to depth based on the measured size of snow grains. Systems and apparatus are also disclosed for sharing the generated profiles among a plurality of users via a central server, and for evaluating an avalanche risk at a geographic location.

Abstract: A split gantry for a CT system includes a rotatable side comprising a configurable arrangement of image chain components of the CT system, a stationary side comprising a stationary support base and a gantry bearing, wherein the rotatable side is separate from the stationary side, and the stationary side is attachable to a rotatable portion of the gantry bearing without having to align the image chain components during an installation of the CT system.

Abstract: The present inventions relate generally to methods, apparatus and systems for measuring snow stability and structure which may be used to assess avalanche risk. The disclosed apparatus includes a sensing unit configured to sense a resistance to penetration as the sensing unit is being driven into a layer of snow. The disclosed apparatus may also be configured to take other environmental measurements, including temperature, humidity, grain size, slope aspect and inclination. Methods and apparatus are also disclosed for generating a profile of snow layer hardness according to depth based on the sensed resistance to penetration and identifying areas of concern which may indicate an avalanche risk. Systems and apparatus are also disclosed for sharing the generated profiles among a plurality of users via a central server, and for evaluating an avalanche risk at a geographic location.

Abstract: The invention relates to the control of gene expression. Specifically, the invention provides compositions and methods for the production and use of recombinant nucleic acid molecules that have the ability to specifically downregulate an expressed target gene in vivo. In some aspects, the invention provides methods for producing a hairpin DNA molecule where part of the molecule is derived from an mRNA that is a target for a small interfering RNA (siRNA) derived from the hairpin. In other aspects, the invention provides synthetic hairpin adapter oligonucleotides that are used in the construction of siRNA-producing cassettes. In other aspects, the invention provides methods for testing for the presence or absence of specific inhibitory activity of an RNAi trigger molecule, and in still other aspects, the invention provides methods for identifying an active RNAi trigger molecule from a library of RNAi trigger molecules.

Abstract: The invention relates to the control of gene expression. Specifically, the invention provides compositions and methods for the production and use of recombinant nucleic acid molecules that have the ability to specifically downregulate an expressed target gene in vivo. In some aspects, the invention provides methods for producing a hairpin DNA molecule where part of the molecule is derived from an mRNA that is a target for a small interfering RNA (siRNA) derived from the hairpin. In other aspects, the invention provides synthetic hairpin adapter oligonucleotides that are used in the construction of siRNA-producing cassettes. In other aspects, the invention provides methods for testing for the presence or absence of specific inhibitory activity of an RNAi trigger molecule, and in still other aspects, the invention provides methods for identifying an active RNAi trigger molecule from a library of RNAi trigger molecules.

Abstract: The present inventions relate generally to methods, apparatus and systems for measuring snow stability and structure which may be used to assess avalanche risk. The disclosed apparatus includes a sensing unit configured to sense a temperature of a layer of snow as the sensing unit is being driven into the layer of snow. The disclosed apparatus may also be configured to take other environmental measurements, including resistance to penetration, humidity, grain size, slope aspect and inclination. Methods and apparatus are also disclosed for generating a profile of snow layer temperature according to depth based on the sensed temperature. Systems and apparatus are also disclosed for sharing the generated profiles among a plurality of users via a central server, and for evaluating an avalanche risk at a geographic location.

Abstract: The present inventions relate generally to methods, apparatus and systems for measuring snow stability and structure which may be used to assess avalanche risk. The disclosed apparatus includes a sensing unit configured to sense a resistance to penetration as the sensing unit is being driven into a layer of snow. The disclosed apparatus may also be configured to take other environmental measurements, including temperature, humidity, grain size, slope aspect and inclination. Methods and apparatus are also disclosed for generating a profile of snow layer hardness according to depth based on the sensed resistance to penetration and identifying areas of concern which may indicate an avalanche risk. Systems and apparatus are also disclosed for sharing the generated profiles among a plurality of users via a central server, and for evaluating an avalanche risk at a geographic location.

Abstract: The present inventions relate generally to methods, apparatus and systems for measuring snow stability and structure which may be used to assess avalanche risk. The disclosed apparatus includes a sensing unit configured to measure a size of snow grains as the sensing unit is being driven into a layer of snow. The disclosed apparatus may also be configured to take other environmental measurements, including resistance to penetration, temperature, humidity, slope aspect and inclination. Methods and apparatus are also disclosed for generating a profile of snow grain size according to depth based on the measured size of snow grains. Systems and apparatus are also disclosed for sharing the generated profiles among a plurality of users via a central server, and for evaluating an avalanche risk at a geographic location.

Abstract: The present inventions relate generally to methods, apparatus and systems for sharing measurements related to snow stability and structure which may be used to assess avalanche risk among multiple users. Such measurements may include a profile of snow layer hardness according to depth, a profile of snow temperature according to depth, a profile of snow grain size according to depth, ambient temperature, slope aspect and inclination, and humidity. The disclosed apparatus includes a mobile device configured to send and receive said measurements, and to display such measurements on an area map. The disclosed apparatus also includes a server configured to receive said measurements from a plurality of mobile devices, analyze the measurements to evaluate the avalanche risk at a geographic area, and transmit said measurements and evaluated avalanche risk to the mobile devices.