Abstract: The present disclosure relates to methods for inactivating a Zika virus which can be used in vaccines and immunogenic compositions. The present disclosure also relates to a method for determining the completeness of inactivation of an arbovirus preparation.

Abstract: A portable, self-contained beverage apparatus includes a container assembly having a known storage capacity for storing a consumable liquid, and a dispensing assembly disposed within the container assembly that dispenses variable, non-zero quantities of additives into the consumable liquid. The dispensing assembly includes multiple apertures structured and arranged to retain vessels containing the additives to be dispensed into the consumable liquid. The beverage apparatus also includes a level sensor disposed within the container assembly that determines a consumable liquid level of the consumable liquid stored in the container assembly. In certain embodiments, one or more positive displacement pumping mechanisms are configured to pump additive liquid from additive containers into a beverage chamber.

Abstract: Various examples are directed to computer-implemented systems and methods for providing a unique market offer code and validation. A method includes generating an offer customized for an intended recipient, and sending the offer electronically to the intended recipient. The method further includes receiving a user selection of the offer, and displaying a landing web page on a graphical user interface (GUI) of a user device. A user selection of an action button on the landing web page is received, and a validation web page is displayed on the GUI, the validation web page including prompts for input of user information. The user information is evaluated to determine authenticity of the offer and to confirm identity of the user as the intended recipient. Upon determining that the user is not approved for the offer, access is provided to the user to an additional offer tailored to the user.

Abstract: A method of enhancing sperm fertility is described herein. The method includes contacting sperm with hydroxyurea. A composition is disclosed that includes sperm, hydroxyurea, and a buffer. Methods, kits, and compositions for enhancing sperm fertility are also provided.

Abstract: A speaker can have a main body with a generally spheroidal shape, which can be supported standing on its end. The speaker can include a subwoofer that faces forward. A plurality of mid-range drivers can be distributed around the sub-woofer, facing generally forward and radially outward. A plurality of tweeters can be distributed around the sub-woofer, facing generally forward and generally outward. The outer housing portion of the speaker can be covered with a fabric material. A user interface ring 162 can be touch sensitive to receive input, and can have a plurality of lights that can be illuminated separately to convey information to the user.

Abstract: Various examples are directed to computer-implemented systems and methods for providing a unique market offer code and validation. A method includes generating an offer customized for an intended recipient, and sending the offer electronically to the intended recipient. The method further includes receiving a user selection of the offer, and displaying a landing web page on a graphical user interface (GUI) of a user device. A user selection of an action button on the landing web page is received, and a validation web page is displayed on the GUI, the validation web page including prompts for input of user information. The user information is evaluated to determine authenticity of the offer and to confirm identity of the user as the intended recipient. Upon determining that the user is not approved for the offer, access is provided to the user to an additional offer tailored to the user.

Abstract: The present invention relates to a fluid flow device. The device includes an elongate body having a proximal end, a distal end, and a length therebetween, at least one source fluid inflow port, at least one waste fluid outflow port, at least one well inlet port positioned at the distal end of the elongate body, at least one well outlet port positioned at the distal end of the elongate body, at least one conduit connecting the at least one source fluid inflow port to the at least one well inlet port, and at least one conduit connecting the at least one waste fluid outflow port to the at least one well outlet port.

Abstract: Systems are provided for generating, modifying and using SBOMs for facilitating risk assessment and threat mitigation for corresponding programs, and particularly for large programming builds. The creation and modification of the SBOMs includes processes for omitting declarations referenced in chunk SBOMs of program chunks incorporated into a final programming build associated with a build SBOM, but which are not actually utilized by the final programming build, as well as processes for adding new declarations for code segments that are not declared in the related chunk SBOMs, even though the code segments are utilized by the final programming build. Systems are also configured to use SBOMs in combination with configuration restriction records to assess and resolve threat events in a manner that can prevent unnecessary remedial actions for threat events that appear to be relevant to one or more files or dependencies incorporated into a program.

Abstract: Systems are provided for generating, modifying and using SBOMs for facilitating risk assessment and threat mitigation for corresponding programs, and particularly for large programming builds. The creation and modification of the SBOMs includes processes for omitting declarations referenced in chunk SBOMs of program chunks incorporated into a final programming build associated with a build SBOM, but which are not actually utilized by the final programming build, as well as processes for adding new declarations for code segments that are not declared in the related chunk SBOMs, even though the code segments are utilized by the final programming build. Systems are also configured to use SBOMs in combination with configuration restriction records to assess and resolve threat events in a manner that can prevent unnecessary remedial actions for threat events that appear to be relevant to one or more files or dependencies incorporated into a program.

Abstract: Systems are provided for generating, modifying and using SBOMs for facilitating risk assessment and threat mitigation for corresponding programs, and particularly for large programming builds. The creation and modification of the SBOMs includes processes for omitting declarations referenced in chunk SBOMs of program chunks incorporated into a final programming build associated with a build SBOM, but which are not actually utilized by the final programming build, as well as processes for adding new declarations for code segments that are not declared in the related chunk SBOMs, even though the code segments are utilized by the final programming build. Systems are also configured to use SBOMs in combination with configuration restriction records to assess and resolve threat events in a manner that can prevent unnecessary remedial actions for threat events that appear to be relevant to one or more files or dependencies incorporated into a program.

Abstract: Various examples are directed to computer-implemented systems and methods for providing a unique market offer code and validation. A method includes generating an offer customized for an intended recipient, and sending the offer electronically to the intended recipient. The method further includes receiving a user selection of the offer, and displaying a landing web page on a graphical user interface (GUI) of a user device. A user selection of an action button on the landing web page is received, and a validation web page is displayed on the GUI, the validation web page including prompts for input of user information. The user information is evaluated to determine authenticity of the offer and to confirm identity of the user as the intended recipient. Upon determining that the user is approved for the offer, access is provided to the user to further information regarding the product.

Abstract: Provided herein are methods for treating a bone-related disorder in a subject. At least one of a microtubule altering drug, for example, a microtubule disrupting drug or a microtubule stabilizing drug, a TRPV4 agonist or a NOX2 activator is administered to the subject. Also provided are related methods for treating a bone-related disorder in the subject by further administering at least one of an anti-sclerostin agent, a parathyroid hormone agonist, a bisphosphonate, an estrogen mimic, or a selective estrogen receptor modulator with the at least one of a microtubule altering drug, a TRPV4 agonist or a NOX2 activator.

Abstract: A vehicle navigation system may include a data pipeline that proposes routing graph modifications from automatically ingested data sources and that provides enough context to suggest an expiration time to remove the routing graph modifications once imposed. The system and method receives from at least one data source routing graph modification data including geographic location data identifying a location to which a routing graph modification applies. The routing graph modification data is associated with one or more roadway elements in a routing graph of a navigation constraints system, and the routing graph modification data associated with the one or more roadway elements is classified as a routing graph modification. The routing graph modification is added to or, if expired, removed from the navigation constraints system.

Abstract: The present invention relates to a fluid flow device. The device includes an elongate body having a proximal end, a distal end, and a length therebetween, at least one source fluid inflow port, at least one waste fluid outflow port, at least one well inlet port positioned at the distal end of the elongate body, at least one well outlet port positioned at the distal end of the elongate body, at least one conduit connecting the at least one source fluid inflow port to the at least one well inlet port, and at least one conduit connecting the at least one waste fluid outflow port to the at least one well outlet port.

Abstract: A system obtains patient data, de-identifies each patient with a unique patient key (UPK) and joins the patient data without linking to personal identities of the patients. The system further receives a search query from a user device, identifies a group of UPKs associated with patient data that satisfies criteria of the search query based on values for associated healthcare attributes, and clusters the group of UPKs with respect to healthcare events. The system then ranks the healthcare events of the clusters and sends a query result including healthcare data that is generated based on the ranking, where the query result conceals any personal identity of any of the patients.

Abstract: A system includes one or more sensors coupled to industrial equipment, wherein the one or more sensors are configured to obtain one or more measurements associated with one or more operating characteristics of the industrial equipment. The system also includes a computing device that includes a user interface and one or more processors. The one or more processors are configured to: receive the one or more measurements of the one or more operating characteristics of the industrial equipment; determine a status of the industrial equipment based on the one or more measurements; determine a date and a time based on the one or more measurements; and update a cell in a grid of cells organized according to time increments based on the status, the date, and the time.

Abstract: The present invention relates to a fluid flow device. The device includes an elongate body having a proximal end, a distal end, and a length therebetween, at least one source fluid inflow port, at least one waste fluid outflow port, at least one well inlet port positioned at the distal end of the elongate body, at least one well outlet port positioned at the distal end of the elongate body, at least one conduit connecting the at least one source fluid inflow port to the at least one well inlet port, and at least one conduit connecting the at least one waste fluid outflow port to the at least one well outlet port.

Abstract: Disclosed are systems and techniques for providing a master health entity index and a data analysis mechanism designed for entity cohort discovery and entity profiling. The entity can be a healthcare facility that diagnoses or treats health conditions and diseases (e.g., hospital, clinic), individuals (e.g., providers, patients, caregivers), healthcare data (e.g., medical conditions, treatments, diagnostic studies, health outcomes), etc. For example, a data analysis mechanism may identify distinctive patient cohorts based on what happened to patients in a hospital and why the occurrence happened, glean insight from the activities of the distinctive patient cohorts, and assist with additional patients with the gleaned insight.

Abstract: In one embodiment, a method includes receiving a first search query including a selection of a first query-domain. The first query-domain may correspond to a first object-type. The method includes identifying a first set of objects of the plurality of objects matching the first object-type. The method includes sending a first search-results interface responsive to the first search query. The first search-results interface may include references to one or more of the identified objects from the first set of objects and one or more query-filter elements. Each query-filter element may correspond to a query-filter associated with the first query-domain. Each query-filter element may be activatable to apply the associated query-filter to the identified objects. The method includes receiving a second search query including a selection of one or more of the query-filters in response to the first user activating the corresponding query-filter elements.

Abstract: Various examples are directed to systems and methods for routing autonomous vehicles. A system may receive an indication of a roadway element associated with a routing graph for routing autonomous vehicles and may determine an impact score for the roadway element. The impact score may describe an impact of applying a routing graph modification to the routing graph to modify routing to the roadway element. Based at least in part on the impact score, the system may apply the routing graph modification to the routing graph to generate a constrained routing graph and generate a route for a first autonomous vehicle based at least in part on the constrained routing graph. The system may instruct the first autonomous vehicle to begin traversing the route.