Abstract: An implantable medical device includes an expandable frame that is expandable between a collapsed configuration for delivery and an expanded configuration for deployment, the expandable frame including a periphery defined by the expandable frame. A covering spans at least part of the expandable frame. An expandable element is secured relative to the periphery, the expandable element is adapted to seal against an irregular body opening such as an irregular-shaped ostium of a patient's LAA (left atrial appendage).

Abstract: An implantable medical device such as but not limited to a left atrial appendage closure (LAAC) device includes an expandable frame that is movable between a collapsed configuration for delivery and an expanded configuration for deployment. The expandable frame may include a plurality of articulating members that are biased into the expanded configuration. The expandable frame may include a biasing member. The LAAC device includes a membrane or covering that spans across an end of the expandable frame.

Abstract: A medical device system may include an occlusive implant including a central hub and a plurality of elongate members configured to shift between extended and radially expanded configurations. The central hub includes a plurality of conduits extending from a proximal end to a radially outward facing surface. The plurality of elongate members is configured to extend through the conduits in the radially expanded configuration. An implant remodeling tool may include an elongate sheath having at least one lumen, a plunger guide, and a plurality of plunger shafts extending from the at least one lumen through the plunger guide. The plunger guide is configured to direct the plunger shafts radially outward as the plunger shafts are advanced distally. The plunger shafts are configured to engage a medical implant and urge at least a portion of the implant radially outward.

Abstract: An implant for occluding a left atrial appendage may include an expandable framework configured to shift between a collapsed configuration and an expanded configuration, wherein the expandable framework includes an attachment point configured to secure the expandable framework to a delivery device, and an occlusive element disposed on a proximal portion of the expandable framework, wherein the occlusive element covers the attachment point.

Abstract: An implantable medical device is adapted to be implanted at an implantation site within the vasculature and is capable of being implanted at the implantation site within the vasculature at more than one position relative to the implantation site. This may include a relative axial position and/or a relative rotational position. The implantable medical device includes an expandable frame that is adapted to expand from a collapsed configuration for delivery to an expanded configuration for deployment, and one or more radiopaque markers disposed relative to the expandable frame such that fluoroscopic imaging of the implantable medical device during deployment provides an indication of a position of the implantable medical device relative to the implantation site. The implantable medical device may be a replacement cardiac valve such as a replacement aortic valve, for example.

Abstract: An example introducer is disclosed. An example introducer includes an inner liner including a lumen, a distal region and at least one folded portion extending along the distal region. The introducer also includes a reinforcing member having a length and including at least one spine extending along the length of the reinforcing member. The introducer also includes a sheath disposed along at least a portion of the introducer, wherein the sheath includes at least one perforation, wherein material adjacent to the at least one folded portion is removed from a distal portion of the introducer to form a tip region. The introducer also includes a tip member disposed along the tip region.

Abstract: An example medical device for occluding the left atrial appendage includes an expandable member having a first end region, a second end region and an inflation cavity. The medical device also includes a plurality of spine members coupled to the expandable member, the plurality of spine members spaced circumferentially around an outer surface of the expandable member. Additionally, the medical device includes a valve member extending at least partially into the inflation cavity, wherein the plurality of spine members are configured to position the medical device within an opening of the left atrial appendage and wherein the expandable member is configured to expand and seal the opening of the left atrial appendage.

Abstract: An implant includes a pair of anchors and a pair of anchor housing assemblies, wherein an anchor housing assembly includes an anchoring component configured to translate the anchor proximally-distally through the anchor housing assembly and a cinch component configured to control a space between the pair of anchor housing assemblies.

Abstract: An implantable medical device such as but not limited to a left atrial appendage closure (LAAC) device includes an expandable frame that is movable between a collapsed configuration for delivery and an expanded configuration for deployment. The expandable frame may include a plurality of frame members that are biased into the expanded configuration. The expandable frame may include a biasing member. The LAAC device includes a membrane or covering that spans across an end of the expandable frame.

Abstract: Example medical devices are disclosed. An example medical device includes an outer shaft and an inner shaft extending within the outer shaft. The medical device also includes a balloon including a distal waist coupled to a distal end of the inner shaft, a proximal waist coupled to a distal end of the outer shaft, an inner surface and a wall. The medical device also includes a first interior partition panel disposed within the balloon, wherein the first interior partition panel is coupled to both the outer surface of the inner shaft and an inner surface of the balloon and a second interior partition panel disposed within the balloon, wherein the second interior partition panel is coupled to both the outer surface of the inner shaft and an inner surface of the balloon. Further, the first interior partition panel is circumferentially spaced away from the second interior partition panel.

Abstract: A delivery system for deploying a medical implant includes a delivery catheter with a lumen, an elongate shaft axially slidably within the lumen, a housing attached to the elongate shaft, and an actuation element disposed within the housing and configured to axially advance and retract the elongate shaft. The actuation element is in direct contact with the elongate shaft and rotation of the actuation element causes axial movement of the elongate shaft.

Abstract: An example medical device for occluding the left atrial appendage is disclosed. The example medical device for occluding the left atrial appendage includes an expandable member having a first end region, a second end region and an inflation cavity. The example medical device includes at least one fixation member having a first end and a second end coupled to the expandable member. The at least one fixation member is configured to move from a delivery configuration to a deployed configuration in response to an expansion of the expandable member. Additionally, the example medical device includes a valve member extending at least partially into the inflation cavity and the expandable member is configured to expand and seal the opening of the left atrial appendage.

Abstract: An implant includes a pair of anchors and a pair of anchor housing assemblies, wherein an anchor housing assembly includes an anchoring component configured to translate the anchor proximally-distally through the anchor housing assembly and a cinch component configured to control a space between the pair of anchor housing assemblies.

Abstract: A latch locking and release system having a control knob operably coupled with a latch system, and a tubular latch release mechanism. The cross-section of the tubular latch release mechanism is shiftable between a locking configuration and a release configuration. In the locking configuration, the control knob maintains latches in the latch system in an engaged configuration, and is blocked from moving to allow the latches to be disengaged. In the release configuration, the control knob may be moved to allow the latches to be disengaged. The latch release mechanism and control knob may have further features preventing inadvertent actuation of the latch locking and release system to allow the latch system to be disengaged.

Abstract: Example medical devices are disclosed. An example medical device includes an elongate shaft having a distal end region and a balloon coupled to the distal end region, the balloon including a wall, a distal waist, a proximal waist and body portion positioned between the distal waist and the proximal waist. The medical device also includes a first reinforced region positioned along the body portion, the first reinforced region including a first plurality of filaments and a second reinforced region positioned along the body portion, the second reinforced region including a second plurality of filaments. Further, the first reinforced region is circumferentially spaced from the second reinforced region such that the balloon wall extending between the first and the second reinforced regions is devoid of a filament.

Abstract: A valve annulus repair system joins anchors at one or both of their proximal and distal ends to construct an implant to reshape the annulus. A removable frame may be used to position the anchors proximate to the annulus and to adjust the shape of the annulus. The frame may support the anchors during deployment of the system, release the anchors during construction of the implant, adjust the shape of the implant (and concomitantly the shape of the reconstructed valve) during an adjustment/cinching process, retain the adjusted shape of the valve annulus while relative anchor positions are secured, and release the anchors to enable the frame to be removed from the deployment site following implant construction. With such a system, a low-profile, flexile annular valve implant with reduced the risks of migration, fracture, embolism and thrombus may be provided.

Abstract: A low profile implant, system and method of deployment includes a plurality of anchors supported by a plurality of anchor housings. The anchor housings include one or more release mechanisms configured to affix the frame to the anchor housings during implant deployment, actuation and cinching, and to release the frame following cinching to enable the frame to be withdrawn from the treatment site.

Abstract: Anchoring assemblies that increase the surface area and/or amount of anchored tissue include a barb anchor, translatably disposed within the opening of an anchor housing, the barb anchor comprising a barb arm, the barb arm including a linear configuration wherein the barb arm is aligned with an axis of the opening and a deflected configuration wherein at least a portion the barb arm is deflected away from a central axis of the opening of the anchor housing.

Abstract: A valve annulus repair system joins anchors at one or both of their proximal and distal ends to construct an implant to reshape the annulus. A removable frame may be used to position the anchors proximate to the annulus and to adjust the shape of the annulus. The frame may support the anchors during deployment of the system, release the anchors during construction of the implant, adjust the shape of the implant (and concomitantly the shape of the reconstructed valve) during an adjustment/cinching process, retain the adjusted shape of the valve annulus while relative anchor positions are secured, and release the anchors to enable the frame to be removed from the deployment site following implant construction. With such a system, a low-profile, flexile annular valve implant with reduced the risks of migration, fracture, embolism and thrombus may be provided.

Abstract: An implantable medical device includes an expandable frame that is moveable between a collapsed configuration for delivery and an expanded configuration for deployment. One or more proximally-facing fixation burrs are secured relative to the expandable frame. One or more distally-facing fixation burrs are secured relative to the expandable frame. The one or more proximally-facing fixation burrs and the one or more distally-facing fixation burrs together provide the implantable medical device with bi-directional stability.