Abstract: A method of altering the targeting and/or cellular uptake efficiency of an adeno-associated virus (AAV) viral vector having a capsid containing an AAV9 cell surface binding domain is described. The method involves modifying a clade F cell surface receptor which comprises a glycan having a terminal sialic acid residue and a penultimate ?-galactose residue. The modification may involve retargeting the vector by temporarily functionally ablate AAV9 binding in a subset of cells, thereby redirecting the vector to another subset of cells. Alternatively, the modification may involve increasing cellular update efficiency by treating the cells with a neuraminidase to expose cell surface ?-galactose. Also provided are compositions containing the AAV9 vector and a neuraminidase. Also provided is a method for purifying AAV9 using ?-galactose linked to solid support.

Abstract: Systems and methods are provided for bimodal refrigeration, which uses a combination of mechanical refrigeration and phase change material (PCM) cells to provide cooling for one or more units of storage, such as freezers, coolers, storage or display cases, open cases (without doors), closed cases (with doors), rack systems (with compressors located remotely), self-contained refrigeration systems (with embedded compressors), in an optimal and efficient manner. In some embodiments, the systems and methods employ intelligent controls which may monitor and receive input for system conditions, time of day, and other conditions, and turn on/off the mechanical refrigeration as appropriate to provide for efficient and cost-effective use of energy.

Abstract: A process and apparatus for catalytically cracking fresh heavy hydrocarbon feed to produce cracked products is disclosed. A fraction of the cracked products can be obtained to re-crack it in a downer reactor. The downer reactor may produce high selectivity to light olefins. Spent catalyst from both reactors can be regenerated in the same regenerator.

Abstract: A process and apparatus for catalytically cracking fresh heavy hydrocarbon feed to produce cracked products is disclosed. A fraction of the cracked products can be obtained to re-crack it in a downer reactor. The downer reactor may produce high selectivity to light olefins. Spent catalyst from both reactors can be regenerated in the same regenerator.

Abstract: Changing operating characteristics of an implement can expand the capabilities of and enhances the productivity of the implement. The disclosed method and apparatus for changing operating characteristics of an implement comprises, providing the operating characteristics of the implement with a predetermined operational range consisting of a plurality of values, connecting the implement with a work machine, sending a first input signal identifying the operational range to an electronic control module, operating the implement at a first value within the operational range, sending a second input signal relating to a second value within the operational range to the electronic control module, and sending an output signal from the electronic control module to one of the work machine and the implement to change from the first value to the second value.

Abstract: A work machine is operably coupled to an interchangeable hydraulically-driven implement via at least one hydraulic line. When changing the hydraulically-driven implement, high pressure trapped within the hydraulic line may cause difficulties in disengaging the attached hydraulically-driven implement from a body of the work machine. The present invention relieves the pressure in the hydraulic line by energizing at least one electronically controlled valve while an engine of the work machine is inactive. The valve is operably coupled to an electrical actuator and is moveable between, at least, a first position and a second position. When the valve is in the first position, the hydraulic line is fluidly connected to a low pressure line. A control system includes a pressure release controller that is operably coupled to energize the electrical actuator and move the valve to the first position when the engine is inactive.

Abstract: A system and process is provided for computer-assisted calculation of the necessary number of carpet tiles needed to cover a given room. The process includes taking known dimensions of the carpet tile, and inputting relevant information with respect to room dimensions to be covered. Based upon the inputted information, the user is provided with information related to the number of tiles needed. The process aids in the efficient installation of tiles to reduce waste and improve appearance.

Abstract: A work machine is operably coupled to an interchangeable hydraulically-driven implement via at least one hydraulic line. When changing the hydraulically-driven implement, high pressure trapped within the hydraulic line may cause difficulties in disengaging the attached hydraulically-driven implement from a body of the work machine. The present invention relieves the pressure in the hydraulic line by energizing at least one electronically controlled valve while an engine of the work machine is inactive. The valve is operably coupled to an electrical actuator and is moveable between, at least, a first position and a second position. When the valve is in the first position, the hydraulic line is fluidly connected to a low pressure line. A control system includes a pressure release controller that is operably coupled to energize the electrical actuator and move the valve to the first position when the engine is inactive.

Abstract: The invention provides a self-contained automatic temperature-responsive three-way line valve. A tubular valve member is axially slidable between first and second limit positions for selectively directing fluid from an inlet port to a first outlet port or a second outlet port. The valve member is disposed between a pair of opposed compression springs, one being a conventional spring biasing the valve member to the first limit position and the other being an SME spring which overcomes the bias of the first-mentioned spring when the fluid exceeds a given temperature.

Abstract: A fluid tampering system for use with a standard water heater storage tank includes a heat exchanger which interposed between the outlet means for conveying heated fluid from the storage tank to a distribution system and the cold fluid inlet means, so that heat energy is transferred between heated fluid exiting and cold water entering the storage tank. Preferably, the heat exchange is complete and water exiting the heat exchanger in both the inlet and outlet conduits are of about equal temperature. In order to avoid the water exiting the water heater to the distribution system becoming too tepid, a bypass conduit either in the inlet means or in the outlet means may be provided triggered by a bypass valve located in the outlet conduit. As a safety feature, a safety shut-off valve is located in the outlet conduit before the distribution system to automatically shut-off the conduit where water exiting the system is above a desired maximum temperature.