Patents by Inventor James M. Croop

James M. Croop has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies for P-glycoprotein encoded by the mdr1 gene and uses thereof
    Patent number: 5369009
    Abstract: A novel antibody capable of binding to a 170,000 dalton P-glycoprotein encoded by the mdr1 gene, wherein said antibody binds to an external epitope on the protein and does not substantially increase the intracellular accumulaton or the cytoxicity of either Daunomycin or vinblastine in multidrug resistant cells is described. Methods of use of such antibodies are also described.
    Type: Grant
    Filed: April 17, 1992
    Date of Patent: November 29, 1994
    Assignee: Dana Farber Cancer Institute
    Inventors: Robert J. Arceci, James M. Croop
  • DNA sequence that encodes the multidrug resistance gene
    Patent number: 5198344
    Abstract: SPONSORSHIPThe invention described herein was supported by a grant from the Medical Research Council of Canada, grants from the National Institutes of Health and a grant from the Ajinomoto Corporation.
    Type: Grant
    Filed: February 6, 1991
    Date of Patent: March 30, 1993
    Assignee: Massachusetts Institute of Technology
    Inventors: James M. Croop, Philippe Gros, David E. Housman