Abstract: A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate formulated in an oil-in-water nanoemulsion (NE) drug delivery system in combination with an immune-oncology (IO) agent to enhance therapeutic efficacy in refractory cancers, such as PDAC. A method of treating cancer, by administering an effective amount of a pharmaceutical composition including an omega03 PUFA-taxoid conjugate in combination with an IO agent encapsulated in an NE drug delivery system to a subject in need of treatment, and treating cancer.

Abstract: A reel-to-reel aerosol collection and storage system for capturing and storing a plurality of separate samples of aerosol particles using electrostatic precipitation technology for collecting such particles onto a tape mechanism for analysis at a future time. The particles are collected onto a region of the collection tape for a defined period of time and then that portion of the collection tape is advanced out of the collection zone and manipulated so as to form sealed pouches or pockets which can be either severed from the collection tape for individual storage in a temperature controlled storage container, or which can be stored on a take-up reel in a temperature controlled environment. The collected aerosol particles are stored with a buffer fluid to preserve and maintain the viability of the collected particles for future extraction and analysis. Several embodiments for forming sealed pouches or pockets and methods of storing the collected particles are disclosed.

Abstract: A reel-to-reel aerosol collection and storage system for capturing and storing a plurality of separate samples of aerosol particles using electrostatic precipitation technology for collecting such particles onto a tape mechanism for analysis at a future time. The particles are collected onto a region of the collection tape for a defined period of time and then that portion of the collection tape is advanced out of the collection zone and manipulated so as to form sealed pouches or pockets which can be either severed from the collection tape for individual storage in a temperature controlled storage container, or which can be stored on a take-up reel in a temperature controlled environment. The collected aerosol particles are stored with a buffer fluid to preserve and maintain the viability of the collected particles for future extraction and analysis. Several embodiments for forming sealed pouches or pockets and methods of storing the collected particles are disclosed.

Abstract: A microchannel for analyte band broadening compensation is disclosed. The microchannel includes a bend having an inside radius of curvature, an outside radius of curvature, and a width. The bend is constructed such that the width and either the inside radius of curvature, the outside radius of curvature or both change simultaneously.