Abstract: Disclosed herein are methods for identifying compounds that enhance base excision repair, as well as compounds identified thereby and methods of using such compounds in the interception of malignancy, i.e. the prevention of progression of a disease from a state of susceptibility to active disease. Exemplified compounds are acetohexamide and related compounds, as well as benserazide and analogs thereof. Exemplified malignancies are those of human breast cells carrying mutations, in particular, SUM149 cells and HCC1937 cells, which cells carry BRCA1 mutations.

Abstract: Disclosed herein are methods for identifying compounds that enhance base excision repair, as well as compounds identified thereby and methods of using such compounds in the interception of malignancy, i.e. the prevention of progression of a disease from a state of susceptibility to active disease. Exemplified compounds are acetohexamide and related compounds, as well as benserazide and analogs thereof. Exemplified malignancies are those of human breast cells carrying mutations, in particular, SUM149 cells and HCC1937 cells, which cells carry BRCA1 mutations.

Abstract: An electrolytic cell construction in which the cell includes at least one anode and cathode, and a separator therebetween held under a compressive force by a frame assembly. The anodes and cathode are provided with a portion for electrical connection to an electric connector plate. The electric connector plate is positioned in contact with a respective anode and cathode. The compressive force of the frame assembly which holds the components of the cell in compression to provide a fluid tight seal simultaneously serves to apply a force between the electrical connector plates and their respective anode or cathode to hold the electrical connector plates in contact therewith. Preferably spring means are provided for biasing the electrical connector plates and the portions of the anode and cathode for connection to the plate into engagement with each other.

Abstract: A process of operating an electrochemical cell with a particular catholyte flow pattern is disclosed wherein the cell is angled from the horizontal and the catholyte is fed into a gap in the cathode compartment between the liquid metal cathode and the membrane on the lower first end and exits the gap on the opposing higher second outlet end.

Abstract: An electrochemical cell is disclosed having a cell bottom or baseplate that has at least one drain hole therein which is fed by drain canals adjacent an end of the catholyte chamber such that the drain holes are gradually inclined to increase in depth laterally downwardly from the opposing sides of the cell toward the center and longitudinally downwardly from the opposing end of the cell toward the drain hole to permit removal or the addition of the liquid metal cathode from the angled electrolytic cell without requiring disassembly of the cell.

Abstract: A particular side frame design for use in an electromechanical cell with a catholyte flow pattern is disclosed wherein the cell is angled from the horizontal and the catholyte is fed into a gap in the cathode compartment between the liquid metal cathode and the membrane on the lower first end and exits the gap on the opposing higher second outlet end. The side frame is obliquely angled on the interior of the cell to prevent the escape of the flowable liquid metal cathode and to prevent contact of the acidic catholyte with the cell bottom.

Abstract: A particular side frame design for use in an electrochemical cell with a catholyte flow pattern is disclosed wherein the cell can be generally horizontal or angled slightly from the horizontal and the catholyte is fed through a transition area into a gap in the catholyte compartment between the liquid metal cathode and the membrane on a first end and exits the gap on an opposing second outlet end. The side frame has opposing sides that are obliquely and downwardly angled in the corners to support the membrane in a wrinkle free manner so that the membrane is obliquely positioned between the liquid metal cathode and the anode. The membrane is above the level of the catholyte where the catholyte enters and exits the catholyte compartment, but drops to a level below the entry and exit points.

Abstract: A method for sensitizing multidrug resistant cells to antitumor agents comprosing contacting multidrug resistant cells, with an effective amount of a compound of the formula ##STR1## wherein n is 1, 2 or 3, X is CF.sub.3, --O--CH.sub.3, Br, I, Cl, H, W and S--CH.sub.3 and R.sup.1 and R.sup.2, independently of each other are --CH.sub.3 --CH.sub.2 --CH.sub.3, CH.sub.2 CH.sub.2 OHCH.sub.2 OH, or NR.sup.1 R.sup.2 form a ring ##STR2## wherein R.sup.3 is --CH.sub.3, CH.sub.2 --CH.sub.3, --H, CH.sub.2 OH and CH.sub.2 CH.sub.2 OH.

Abstract: A soccerball returner is provided which has a goal portion comprising a ball capturing box-like member with an open front side and a bottom wall which directs a captured ball toward a ball return mechanism. The ball return mechanism includes a ball engaging element, which may be in the form of a motor driven crank arm or a spring loaded solenoid, to impart sufficient momentum to the ball to cause it to be driven away from the soccerball returner.

Abstract: An electrolytic membrane cell for the electrochemical production of an alkali metal hydrosulfite by the reduction of an alkali metal biosulfite component of a circulated aqueous catholyte solution is provided. The cell utilizes an improved extended surface multipass porous cathode, an improved catholyte flow path and a hydrophilically treated separator mesh that separates the cation exchange membrane from the anode.

Abstract: An electrolytic cell jumper switch system is disclosed which eliminates all damaging reverse currents without utilizing any additional rectifiers, power supply or auxiliary power or current sources by loading the electrical current flow through resistor modules around the cell to be disconnected, bypassing the current flow around the bus bar connection between the adjacent cells and the cell to be disconnected by closing a connecting switch and finally reopening the connecting switch to transfer the total current load in the switch back to the resistor modules.

Abstract: Method and means for automatically controlling chlor-alkali cells are described. Control is exercised on the basis of a mass flow analysis, starting from a target caustic concentration for the catholyte output, to establish individual set points for optimum cell system operating conditions so as to achieve said target output value. Such control is accomplished by a central automatic control unit which is adapted to monitor the operation of the cell and its associated brine and caustic output subsystems and to institute appropriate corrective actions whenever a tolerance band around one or more of said set points is exceeded.The control unit is further adapted to provide daily and weekly operating summaries and to store said summaries for trends analyses to establish the scope and significance of any long-term degradative processes which might be occurring.

Abstract: In an electrolytic cell there is provided an improved gas-liquid disengager design which employs an arcuate interior periphery in conjunction with the existing kinetic energy of the electrolyte fluid as the fluid exits the electrolysis compartment of each electrode and enters the disengager along a predetermined path of flow that is tangential to the internal periphery to disengage the electrolytic product gas more efficiently in a compact gas-liquid disengager.

Abstract: A composite fiber reinforced plastic frame is provided wherein a core material at least partially formed from the continuous wrapping of roved layers of glass fiber impregnated with a catalyzed thermosetting resin within a corrosion resistant liner and the frame is reinforced at the corners.

Abstract: The invention relates to an electrolytic cell which is comprised of a first frame member housing an electrode and a second frame member housing an electrode. A separator is positioned between the first frame member and the second frame member. A first sealing means contacts a side of the first frame member and one side of the separator. Contacting the second frame member is a second sealing means having a raised portion which also contacts a side of the separator. Pressing means are provided which press the frames together against the sealing means and the separator to form a substantially fluid-tight seal. The novel electrolytic cells provide the advantages of simultaneously:a. controlling gasket compression pressures,b. controlling gasket frame surface structural forces,c. efficiently forming a seal, andd. preventing gasket slippage.

Abstract: A composite fiber reinforced plastic frame is provided wherein a core material at least partially formed from the continuous wrapping of roved layers of glass fiber impregnated with a catalyzed thermosetting resin within a corrosion resistant liner and the frame is reinforced at the corners.

Abstract: The invention relates to an electrolytic cell which is comprised of a first frame member housing an electrode and a second frame member housing an electrode. A separator is positioned between the first frame member and the second frame member. A first sealing means contacts a side of the first frame member and one side of the separator. Contacting the second frame member and the opposite side of the separator is a second sealing means. The first sealing means and the second sealing means are elastomeric solids having a substantially rectangular cross-sectional area where the first sealing means is from about 1.1 to about 3 times the width of the second sealing means. Pressing means are provided which press the frames together against the sealing means and the separator to form a substantially fluid-tight seal. The novel electrolytic cells provide the advantages of simultaneously:a. controlling gasket compression pressures,b. controlling gasket frame surface structural forces,c.

Abstract: A method for assembling a filter press type of electrolytic cell is disclosed wherein tightening apparatus is employed at preferably multiple points about the periphery of the stacked electrodes to substantially simultaneously apply a substantially uniform pressure to compress the cell to permit the compressed stack of electrodes to be retained in this compressed state while the cell is assembled in a fluid-tight manner.

Abstract: In an electrolytic cell, spacers of predetermined thickness are positioned with improved sealing apparatus between the plurality of adjacently positioned and generally parallel electrodes to define and maintain a uniform gap of predetermined thickness between planes which pass through at least the adjacent sides of each pair of adjacent electrode frames.

Abstract: In an electrolytic cell lubricous material is provided between at least one gasket and the adjacent surface of the membrane between adjacent electrode frames to permit the gasket to deform during assembly and operation of the cell when compressive force is applied to effect fluid-tight seals between the gaskets and the adjacent electrode frames without damaging the membrane.