Abstract: Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.

Abstract: An integrated circuit for a fluid ejection device having actuators to operate during a non-reset operating condition is disclosed. The integrated circuit includes a reset input to receive a reset signal activated for a duration. The reset signal generates a reset condition in the integrated circuit. The integrated circuit also includes a monitor circuit operably coupled to the reset input to indicate if the duration of the reset signal meets or exceeds a selected duration and a nonvolatile memory device having data accessible during the reset condition.

Abstract: A die may include a plurality of fluid pumps, at least one strain gauge sensor to sense a strain in the die, and at least one temperature sensor to sense the temperature of the die to compensate for a temperature component of the sensed strain.

Abstract: An integrated circuit for a fluid ejection device having actuators to operate during a non-reset operating condition is disclosed. The integrated circuit includes a reset input to receive a reset signal activated for a duration. The reset signal generates a reset condition in the integrated circuit. The integrated circuit also includes a monitor circuit operably coupled to the reset input to indicate if the duration of the reset signal meets or exceeds a selected duration and a nonvolatile memory device having data accessible during the reset condition.

Abstract: An integrated circuit to drive a plurality of actuators during a non-reset operating condition is disclosed. The integrated circuit includes a reset input to receive a reset signal activated for a duration. The reset signal generates a reset condition in the integrated circuit during which the non-reset operating condition is blocked. The integrated circuit also includes a monitor circuit operably coupled to the reset input to indicate if the duration of the reset signal meets or exceeds a selected duration.

Abstract: A die for a printhead is provided in examples. The die includes a memory voltage regulator disposed on the die, and a high-voltage protection switch disposed on the die in a path of a conductive connection between the memory voltage regulator and a sense bus.

Abstract: An integrated circuit is disclosed. The integrated circuit includes an actuator to eject a fluid in response to a fire signal. The integrated circuit also includes a monitor circuit set by the fire signal to block the fire signal to the actuator circuit after a selected duration.

Abstract: A die for a printhead is provided in examples. The die includes a memory voltage regulator disposed on the die, and a high-voltage protection switch disposed on the die in a path of a conductive connection between the memory voltage regulator and a sense bus.

Abstract: A method for use with a series of analog delay circuits to drive a plurality of actuators with a fire signal is disclosed. A bias signal to affect a selected delay in the analog delay circuits is disabled. The fire signal is provided through the series of analog delay circuits with the bias signal disabled.

Abstract: A fluidic die may include an array of fluid actuators comprising a first set of fluid actuators and a second set of fluid actuators. The fluidic die may further include a first power line connected to the first set of fluid actuators, a second power line connected to the second set of fluid actuators and a third power line connected to the first set of fluid actuators.

Abstract: An integrated circuit to drive a plurality of fluid actuators is disclosed. The integrated circuit analog delay circuits coupled in series and to a fire input to receive a fire signal in succession. Each analog delay circuit receives the fire signal and, after a delay, provides the fire signal via an output to a corresponding fluid actuator. A bias circuit is coupled to each of the of analog delay circuits. The bias circuit provides a bias signal to control the delay.

Abstract: An integrated circuit is disclosed. The integrated circuit includes an actuator to eject a fluid in response to a fire signal. The integrated circuit also includes a monitor circuit set by the fire signal to block the fire signal to the actuator circuit after a selected duration.

Abstract: An integrated circuit to drive a plurality of actuators during a non-reset operating condition is disclosed. The integrated circuit includes a reset input to receive a reset signal activated for a duration. The reset signal generates a reset condition in the integrated circuit during which the non-reset operating condition is blocked. The integrated circuit also includes a monitor circuit operably coupled to the reset input to indicate if the duration of the reset signal meets or exceeds a selected duration.

Abstract: A die may include a plurality of fluid pumps, at least one strain gauge sensor to sense a strain in the die, and at least one temperature sensor to sense the temperature of the die to compensate for a temperature component of the sensed strain.

Abstract: A fluidic die may include a substrate having a flexible region opposite a fluid supply passage within the substrate, a nozzle supported by the substrate proximate the flexible region and a strain sensor on the flexible region of the substrate. The strain sensor may sense strain during flexing of the flexible region to sense fluid back pressure changes.

Abstract: A fluidic die may include a fluid actuator comprising an electrical resistor, a power node to supply electrical current to the resistor to drive the fluid actuator, a low side switch transistor connected to a ground node and having a gate to control the flow of electrical current through the resistor, a voltage regulator to receive electrical power from the power node and to output a predetermined voltage and a level shifter to control to output a low side switch transistor gate drive voltage using the predetermined voltage and based upon control signals to control the gate to control fluid displacement by the fluid actuator. The predetermined voltage is greater than a voltage of the control signals and is independent of a resistance of the ground node.

Abstract: A die includes a plurality of fluid actuation devices and at least one strain gauge sensor to sense strain. The die also includes at least one temperature sensor to sense the temperature of the die to compensate for a temperature component of the sensed strain.

Abstract: A die includes a plurality of fluid actuation devices and at least one strain gauge sensor to sense strain. The die also includes at least one temperature sensor to sense the temperature of the die to compensate for a temperature component of the sensed strain.

Abstract: A fluidic die may include a fluid actuator comprising an electrical resistor, a power node to supply electrical current to the resistor to drive the fluid actuator, a low side switch transistor connected to a ground node and having a gate to control the flow of electrical current through the resistor, a voltage regulator to receive electrical power from the power node and to output a predetermined voltage and a level shifter to control to output a low side switch transistor gate drive voltage using the predetermined voltage and based upon control signals to control the gate to control fluid displacement by the fluid actuator. The predetermined voltage is greater than a voltage of the control signals and is independent of a resistance of the ground node.

Abstract: A fluidic die may include an array of fluid actuators comprising a first set of fluid actuators and a second set of fluid actuators. The fluidic die may further include a first power line connected to the first set of fluid actuators, a second power line connected to the second set of fluid actuators and a third power line connected to the first set of fluid actuators.