Patents by Inventor James M. Hasler

James M. Hasler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chimeric insecticidal proteins
    Patent number: 11781152
    Abstract: IRDIG35563 vegetative insecticidal toxins, polynucleotides encoding such toxins, use of such toxins to control pests, and transgenic plants that produce such toxins are disclosed. The invention includes IRDIG35563 variants, fragments and analogs.
    Type: Grant
    Filed: February 14, 2022
    Date of Patent: October 10, 2023
    Assignee: CORTEVA AGRISCIENCE LLC
    Inventors: Marc D Zack, Megan Sopko, James M Hasler
  • NOVEL INSECTICIDAL TOXIN RECEPTORS AND METHODS OF USE
    Publication number: 20230193403
    Abstract: The disclosure relates to insecticidal toxin resistance management and screening of novel insecticidal toxin receptors for insect resistance. One embodiment relates to the isolation, characterization, compositions, and methods of use relating to polynucleotides encoding novel insecticidal toxin receptors and the polypeptides encoded thereby. The polynucleotides and polypeptides are useful in identifying or designing insect pest management strategies.
    Type: Application
    Filed: March 9, 2021
    Publication date: June 22, 2023
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: SAMANTHA L GRIFFIN, JAMES M HASLER, DEIRDRE KAPKA-KITZMAN, USHA MUPPIRALA, MARK EDWARD NELSON, XIPING NIU
  • NOVEL INSECTICIDAL TOXIN RECEPTORS AND METHODS OF USE
    Publication number: 20220380418
    Abstract: The disclosure relates to insecticidal toxin resistance management and screening of novel insecticidal toxins. One embodiment relates to the isolation, characterization, compositions, and methods of use relating to polynucleotides encoding novel insecticidal toxin receptors and the polypeptides encoded thereby. The polynucleotides and polypeptides are useful in identifying or designing novel insecticidal toxin receptor ligands including novel insecticidal toxins.
    Type: Application
    Filed: August 2, 2019
    Publication date: December 1, 2022
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: CLAIRE MARIE BAZYK, CATHERINE J CLARK, RUTH CONG, JAMES M HASLER, JINGTONG HOU, NAGA KISHORE KAKANI, DEIRDRE KAPKA-KITZMAN, SONG LENG, JOHN P MATHIS, MARK EDWARD NELSON, TAKASHI YAMAMOTO
  • CHIMERIC INSECTICIDAL PROTEINS
    Publication number: 20220162635
    Abstract: IRDIG35563 vegetative insecticidal toxins, polynucleotides encoding such toxins, use of such toxins to control pests, and transgenic plants that produce such toxins are disclosed. The invention includes IRDIG35563 variants, fragments and analogs.
    Type: Application
    Filed: February 14, 2022
    Publication date: May 26, 2022
    Applicant: CORTEVA AGRISCIENCE LLC
    Inventors: MARC D. ZACK, MEGAN SOPKO, JAMES M HASLER
  • Chimeric insecticidal proteins
    Patent number: 11274315
    Abstract: IRDIG35563 vegetative insecticidal toxins, polynucleotides encoding such toxins, use of such toxins to control pests, and transgenic plants that produce such toxins are disclosed. The invention includes IRDIG35563 variants, fragments and analogs.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: March 15, 2022
    Assignee: CORTEVA AGRISCIENCE LLC
    Inventors: Marc D Zack, Megan Sopko, James M Hasler
  • CHIMERIC INSECTICIDAL PROTEINS
    Publication number: 20200318132
    Abstract: IRDIG35563 vegetative insecticidal toxins, polynucleotides encoding such toxins, use of such toxins to control pests, and transgenic plants that produce such toxins are disclosed. The invention includes IRDIG35563 variants, fragments and analogs.
    Type: Application
    Filed: September 26, 2018
    Publication date: October 8, 2020
    Applicant: DOW AGROSCIENCES LLC
    Inventors: MARC D ZACK, MEGAN SOPKO, JAMES M HASLER
  • Methods for purifying insect membrane-bound receptor proteins from recombinant production hosts
    Patent number: 9163225
    Abstract: The invention is drawn to a method for purifying membrane-bound proteins expressed in recombinant insect cells using N-laurosarcosine. The invention is particularly suited for expressing cadherin-type receptors cloned from Ostrinia nubilalis, European Corn Borer, and expressed in Sf9 insect cells. The method is optionally adapted for use with 6-his tag proteins.
    Type: Grant
    Filed: December 27, 2013
    Date of Patent: October 20, 2015
    Assignee: Dow AgroSciences LLC
    Inventors: James M. Hasler, Jianquan Li, Joel J. Sheets
  • Assays utilizing nicotinic acetylcholine receptor subunits
    Patent number: 9005981
    Abstract: The present invention is in the field of identification and characterization of novel insecticidal target sites and, in particular, relates to host cells, assays and antibodies thereto.
    Type: Grant
    Filed: December 22, 2009
    Date of Patent: April 14, 2015
    Assignee: Dow AgroSciences LLC
    Inventors: Nailah Orr, Gerald B. Watson, Gary D. Gustafson, James M. Hasler, Chaoxian Geng, Scott Chouinard, Kevin R. Cook, Vincent L. Salgado
  • Methods For Purifying Insect Membrane-Bound Receptor Proteins From Recombinant Production Hosts
    Publication number: 20140187758
    Abstract: The invention is drawn to a method for purifying membrane-bound proteins expressed in recombinant insect cells using N-laurosarcosine. The invention is particularly suited for expressing cadherin-type receptors cloned from Ostrinia nubilalis, European Corn Borer, and expressed in Sf9 insect cells. The method is optionally adapted for use with 6-his tag proteins.
    Type: Application
    Filed: December 27, 2013
    Publication date: July 3, 2014
    Applicant: Dow AgroSciences LLC
    Inventors: James M. HASLER, Jianquan LI, Joel J. SHEETS
  • NOVEL ASSAYS UTILIZING NICOTINIC ACETYLCHOLINE RECEPTOR SUBUNITS
    Publication number: 20100212029
    Abstract: The present invention is in the field of identification and characterization of novel insecticidal target sites and, in particular, relates to host cells, assays and antibodies thereto.
    Type: Application
    Filed: December 22, 2009
    Publication date: August 19, 2010
    Applicant: DOW AGROSCIENCES LLC
    Inventors: Nailah Orr, Gerald B. Watson, Gary D. Gustafson, James M. Hasler, Chaoxian Geng, Scott Chouinard, Kevin R. Cook, Vincent L. Salgado
  • Antibody-mediated down-regulation of plant proteins
    Patent number: 6767742
    Abstract: Monoclonal antibodies expressed in plant cells bind targeted transit peptides to decrease steady state levels of passenger proteins in plant organelles.
    Type: Grant
    Filed: July 21, 1999
    Date of Patent: July 27, 2004
    Assignee: Dow AgroSciences LLC
    Inventors: Kitisri Sukhapinda, James M. Hasler, James K. Petell, James A. Strickland, Otto Folkerts