Abstract: The present invention relates generally to the fields of medicine, immunology, and cancer biology. More particularly, it concerns antibodies that target HSP70 and methods of their use. Provided herein are agents such as antibodies that target HSP70. Methods of treating cancer are provided, comprising administering to a patient in need thereof an effective amount of an HSP70-targeting agent such as an HSP70-specific antibody. The HSP70-specific antibody may enhance uptake of HSP70 by antigen presenting cells.

Abstract: Systems and processes for providing and updating user interfaces for search functions are provided. An example process includes, at a computer system including a touch sensitive display and one or more input devices: receiving, via the one or more input devices, a request to display a user interface; in response to receiving the request to display the user interface, displaying, via the touch sensitive display, the user interface including an affordance including an indication of a number of pages of the user interface; and while displaying the user interface: detecting an occurrence of a predetermined condition; and in response to detecting the occurrence of the predetermined conditions, updating the affordance to include an indication of a search function.

Abstract: A tool kit for unlocking a door knob lock set which bypasses the cylinder and pin pairs which normally must be aligned properly with the proper key. The tool kit includes a pin lifting tool which is used to move the pins so that a forked tool is inserted into the key way, through the cylinder, through an aperture in the end of the cylinder and on to the shaft which must be turned to unlock the lock. The forked tool straddles the shaft and then the forked tool is turned, thereby turning the shaft and unlocking the lock.

Abstract: A crankable hand wrench includes an elongated main handle having opposite end portions, opposite faces extending between the opposite end portions, and a slot in the main handle nearer to one than the other of the opposite end portions, a wrench head attached to and extending from at least the other of the opposite end portions of the main handle, and a crank assembly incorporated by the main handle. The slot is formed through the main handle between the opposite faces thereof so as to open at the opposite faces. The crank assembly includes a crank handle movable between a stored position in which the crank handle is disposed within the slot and a deployed position in which the crank handle extends from the main handle so as to form a substantially L-shaped crank therewith.

Abstract: A mass moves within a bore defined in a body. During normal operation the axis of the bore is approximately vertical, so that the mass rests at the bottom. A magnet is positioned adjacent the top of the bore and imparts an upwards force on the mass that is less than the downwards force on the mass upwards force on the mass that is less than the downwards force on the mass from gravity. A coil is positioned adjacent the bottom of the bore. When the body is dropped, or tilted beyond a critical angle from vertical, the force from the magnet causes the mass to move upwards in the bore. The upwards movement is sensed as a change in the coil's inductance.

Abstract: An enhanced method and system for unloading magnetic heads are disclosed. The system limits the maximum and minimum speed of the actuator while unloading the heads during a power failure. A BEMF control circuit monitors the velocity of the actuator using the BEMF of the actuator as a gauge of the velocity. The BEMF control circuit uses a sense resistor to remove the inherent resistive component of the actuator from its BEMF measurement. If the velocity of the actuator increases above a safe level the BEMF control circuit decreases actuator current to prevent further acceleration. If the velocity of the actuator decreases below a safe level the BEMF control circuit increases the actuator current to accelerate the actuator to a safe level.

Abstract: A crankcase fuel injection system includes a diaphragm type fuel pump, a crankcase fuel injector assembly, and a main air inlet assembly. Engine crankcase pulses generated by the up and down movements of the piston are utilized by the fuel pump to replenish the fuel mixture in a fuel mixture injector chamber of the fuel injector assembly. The air mass entering the crankcase upon the upstroke of the piston is controlled within the main air inlet assembly by a throttle valve and metered across a main air venturi. The venturi signal at the main air venturi is amplified by a booster venturi. The amplified venturi signal is applied to a middle chamber formed between the two diaphragms of the compound diaphragm assembly which serves as the injector pump mechanism. The force acting upon the diaphragm assembly due to the amplified venturi signal is further amplified due to the area relationships of the two diaphragms.

Abstract: A fuel sensing diaphragm and an air sensing diaphragm apply opposing forces to a transfer member. The forces applied by the fuel sensing diaphragm are based upon the flow rate of fuel, and the forces applied by the air sensing diaphragm are based upon the air flow rate through a venturi. The fuel sensing diaphragm, transfer member, and air sensing diaphragm move together as a control unit which controls the amount of free air allowed to enter an air chamber. Free air in the air chamber is bled off across a vacuum orifice connected to a vacuum port below the throttle plate. The air chamber is in fluid communication with a regulator air chamber. The regulator air chamber is separated from a regulator fuel chamber by a regulator diaphragm and plunger. The regulator diaphragm and plunger operates a fuel inlet ball valve which controls the flow of fuel.

Abstract: A single pivoting diaphragm plate is utilized to separate the two air-sensing chambers and the two fuel-sensing chambers. The diaphragm plate is bonded to a resilient diaphragm/seal which separates and seals the four chambers and allows for the pivoting action of the diaphragm plate as it seeks to balance the forces of the air velocity and the fuel velocity. Any imbalance between the forces is sensed across the diaphragm plate, which immediately results in a pivoting movement to return the system to a balanced condition. The pivoting action of the diaphragm plate controls the fuel discharge valve which feeds fuel into an accelerated air passageway which enters the main air stream below a throttle plate.

Abstract: A device for the blending of gases or liquids having an inlet adapter, a main body, an outlet adaptor, a valve plate, and a spring arm. Air enters the inlet adaptor and passes through an air port in the main body. Fuel is supplied to a fuel port in the main body through a nipple and a passage. The fuel port and the air port share a common valve seating plane and are aligned side by side along the innermost edge of the valve seating plane. The spring arm applies a force to the valve plate which forces the valve plate towards the valve seating plane. The valve plate pivots about the innermost edge of the valve seating plane in response to the downstream demand for the blend and forms a common angle above the air and fuel ports, which results in proportionally exposed port areas. The downstream demand for the blend provides a pressure difference across the valve plate which acts against the valve plate spring to position the valve plate to a balanced position.

Abstract: An improved mechanical air-fuel blending system for use with internal combustion engines, in which a highly compressed fuel such as Liquified Petroleum (LP), is throttled at its storage pressure across a single fuel valve before entering a fuel flow divider which allows the main portion of the discharged LP to flow directly into the air stream before passing to the internal combustion engine. A small portion of the discharged fuel, termed the control fuel, is separated within a fuel flow divider and is diverted across one or more heat exchangers, where it transfers heat to and from the incoming air charge which brings the temperature of the control fuel to that of the incoming air, before entering the air stream at the venturi across one or more orifices. The control fuel pressure within the heat exchanger is compared with the free air pressure entering the system, across a light diaphragm to control the positioning of a fuel valve.

Abstract: One end section of a three section tubular coupling body is connected to a flexible hose, and the opposite end section supports a manually actuated coupler for releasably locking the body to a valve fitting of an air conditioning or refrigeration system. A valve member is supported within the body for axial movement between an extended open position and a retracted closed position. In its extended position, the valve member opens a valve stem within the fitting and opens a flow valve within the body. In its retracted position, the valve member closes the fitting valve and the flow valve. A manually actuated lever is connected by rotary cam members to move the valve member and is effective to block disconnection of the coupler when the valve member is in its extended open position and to lock the valve member in its retracted closed position.

Abstract: A tubular body supports a fluid actuated tubular piston connected to operate a coupling mechanism for releasably securing the body to a valve or inlet fitting on a refrigerant or coolant receiving system. The body encloses components which define a center passage connected to the fitting for first evacuating air from the system and then for directing liquid refrigerant or coolant into the system. In one embodiment, the passage receives an elongated valve opening member which is fluid actuated to a position opening the valve fitting, and a movable valve member closes the passage to the flow of refrigerant. The fluid actuated coupling mechanism provides for convenient and simple insertion of the tool assembly onto the fitting with no insertion force and also for automatic release of the tool assembly from the fitting after charging is completed. A fluid actuated valve member minimizes the loss of coolant or the volume of residue refrigerant which vaporizes when the tool assembly is removed from the fitting.

Abstract: A tubular body supports a fluid actuated tubular piston connected to operate a coupling mechanism for releasably securing the body to a valve fitting on a refrigerant receiving system. The body encloses components which define a center passage connected to the fitting for first evacuating air from the system and then for directing liquid refrigerant into the system. The passage receives an elongated valve opening member which is fluid actuated to a position opening the valve fitting, and a movable valve member closes the passage to the flow of refrigerant. The fluid actuated coupling mechanism provides for convenient and simple insertion of the tool assembly onto the fitting with no insertion force and also for automatic release of the tool assembly from the fitting after charging is completed. A fluid actuated valve member minimizes the volume of residue refrigerant which vaporizes when the tool assembly is removed from the fitting.

Abstract: A tubular body supports a fluid actuated tubular piston connected to operate a coupling mechanism for releasably securing the body to a valve fitting on a refrigerant receiving system. The body encloses components which define a center passage connected to the fitting for first evacuating air from the system and then for directing liquid refrigerant into the system. The passage receives an elongated valve opening member which is fluid actuated to a position opening the valve fitting, and a movable valve member closes the passage to the flow of refrigerant. The fluid actuated coupling mechanism provides for convenient and simple insertion of the tool assembly onto the fitting with no insertion force and also for automatic release of the tool assembly from the fitting after charging is completed. A fluid actuated valve member minimizes the volume of residue refrigerant which vaporizes when the tool assembly is removed from the fitting.