Abstract: An optical filter used in applications involving spectroscopic measurements is fabricated by depositing layers of optical coatings onto a substrate. The layers are deposited so as to have a substantially constant thickness in a first direction along the surface of the substrate, and a gradually increasing thickness along a direction perpendicular to the first direction. The structure of the optical filter allows for large scale production of the filter so that costs in producing the filter are greatly reduced. The filter may be used in a variety of applications including, but not limited to chemical analysis, blood glucose monitoring, and the like.

Abstract: The method and apparatus of the present invention provides a system wherein light-emitting diodes (LEDs) can be tuned within a given range by selecting their operating drive current in order to obtain a precise wavelength. The present invention further provides a manner in which to calibrate and utilize an LED probe, such that the shift in wavelength for a known change in drive current is a known quantity. In general, the principle of wavelength shift for current drive changes for LEDs is utilized in order to allow better calibration and added flexibility in the use of LED sensors, particularly in applications when the precise wavelength is needed in order to obtain accurate measurements. The present invention also provides a system in which it is not necessary to know precise wavelengths of LEDs where precise wavelengths were needed in the past. Finally, the present invention provides a method and apparatus for determining the operating wavelength of a light emitting element such as a light emitting diode.

Abstract: A blood glucose monitoring system includes a broadband light source and a specially fabricated optical filter for modulating optical radiation to be transmitted through a fleshy medium. Optical radiation which passes through the fleshy medium is detected by an optical detector which generates an electrical signal indicative of the intensity of the detected light. Digital signal processing is performed on the electrical signal to extract those optical characteristics of the electrical signal due to the optical characteristics of the filter and constituents of the fleshy May 1, 1995 medium other than blood glucose concentration. The monitoring system employs a unique "double-log" transformation to minimize errors due to indeterminate path length variations of the optical radiation through the fleshy medium. The monitoring system further employs specialized signal processing to avoid inaccuracies due to the previously unidentified solvent effect which arises when glucose is dissolved into water.

Abstract: An optical probe for measurements, which is particularly suited to reduce noise in measurements taken on an easily compressible material, such as a finger, a toe, a forehead, an earlobe, or a lip. The probe includes a base having an aperture which leads to a chamber. The base is placed adjacent a portion of the material, the chamber being placed directly adjacent any easily compressible portion of the material. A photodetector is located within the chamber and does not contact the material. A light emitting diode (LED) is affixed to the material, opposite the photodetector and above the chamber. The material which is supported by the aperture and therefore rests above or has intruded into the chamber is inhibited from compression since nothing comes in contact with this portion of the material, even when the material moves. Thus, light from the LED is directed through a stabilized portion of the material, i.e.

Abstract: A blood glucose monitoring system is disclosed which provides for inducing an active pulse in the blood volume of a patient. The induction of an active pulse results in a cyclic, and periodic change in the flow of blood through a fleshy medium under test. By actively inducing a change of the blood volume, modulation of the volume of blood can be obtained to provide a greater signal to noise ratio. This allows for the detection of constituents in blood at concentration levels below those previously detectable in a non-invasive system. Radiation which passes through the fleshy medium is detected by a detector which generates a signal indicative of the intensity of the detected radiation. Signal processing is performed on the electrical signal to isolate those optical characteristics of the electrical signal due to the optical characteristics of the blood.

Abstract: The forward light scattering photometer for analyzing particles dispersed in a fluid includes a cylindrical housing enclosing a pair of axially spaced, spherical-surfaced, bi-convex lenses which provide axial focusing of the lamp image in an intermediate light scattering chamber through which the sample being analyzed is flowed. Such lenses provide axial focusing with no circumferential aberations and only radial aberations. Light traps having radial borders, such as semicircular blank off discs, are located on the upstream or lamp side of each lens to provide an image having sharp radial edges, thereby eliminating the need for high quality lenses adapted to correct for spherical aberations.The lenses are shielded from contamination by particles from the sample by a stream of purge air introduced into the housing at a location near each lens and tangentially with the housing bore so as to create a stable vortexing flow of the purge air in the vicinity of each lens.