Abstract: A new family of rare-earth silicate compositions and the synthetic methods used to prepare them. The materials have open-framework structures and are characterized by their ion-exchange properties. They are represented by the following empirical formula: Ar+pMs+1-xM?t+xSinOm where A is an exchangeable cation such as sodium, M is at least one element selected from the group of rare-earth elements, and M? is a framework metal having a valence of +2, +3, +4, or +5. The rare-earth silicate materials have utility in various cation-exchange applications such as dialysis and removal of toxic metals from the gastrointestinal tract.

Abstract: A method of stimulating ventilatory and/or respiratory drive in a subject in need thereof includes administering to the subject a therapeutically effective amount of a composition comprising an glutathione alkyl ester, adduct thereof, or pharmaceutically acceptable salt, tautomer, or solvate thereof.

Abstract: A process for removing Pb2+ toxins from bodily fluids is disclosed. The process involves contacting the bodily fluid with an ion exchange composition to remove the metal toxins in the bodily fluid, including blood and gastrointestinal fluid. Alternatively, blood can be contacted with a dialysis solution which is then contacted with the ion exchange composition. The ion exchange compositions are represented by the following empirical formula: AmTiaNb1-aSixOy having either the pharmacosiderite, sitinakite, pharmacosiderite-sitinakite intergrowth topologies or mixtures thereof. A composition comprising the above ion exchange compositions in combination with bodily fluids or dialysis solution is also disclosed. The ion exchange compositions may be supported by porous networks of biocompatible polymers such as carbohydrates or proteins.

Abstract: The present disclosure provides a class of bifunctional compounds that includes an IGF-2 polypeptide that specifically binds to a cell surface cation independent mannose-6-phosphate receptor (CI-M6PR), and a target binding moiety. The bifunctional compounds can trigger the CI-M6PR cell surface receptor to internalize into the cell a complex of the target and the bifunctional compound. The target can be an extracellular target protein such as a soluble protein or a membrane bound target protein. The target binding moiety can be an antibody or antibody fragment. Also provided are methods of using the bifunctional compounds for sequestration and/or lysosomal degradation of a target, e.g., an extracellular target protein associated with a disease or disorder of interest.

Abstract: A process for removing Pb2+ toxins from bodily fluids involves contacting the bodily fluid with an ion exchange composition to remove the metal toxins in the bodily fluid, including blood and gastrointestinal fluid. Alternatively, blood can be contacted with a dialysis solution which is then contacted with the ion exchange composition. The ion exchange compositions are represented by the following empirical formula: AmTiaNb1-aSixOy having either the pharmacosiderite, sitinakite, pharmacosiderite-sitinakite intergrowth topologies or mixtures thereof. There are also compositions comprising the above ion exchange compositions in combination with bodily fluids or dialysis solution. The ion exchange compositions may be supported by porous networks of biocompatible polymers such as carbohydrates or proteins.

Abstract: A challenge/response system separates a physically unclonable function from the challenge/response. Bits in a challenge are used to qualify random data values. The random data values are permuted to generate a result. The result is used to encrypt a response that is sent in reply to the challenge. Additional permuting mechanisms may be used to further obfuscate the response.

Abstract: A challenge/response system separates a physically unclonable function from the challenge/response. Bits in a challenge are used to qualify random data values. The random data values are permuted to generate a result. The result is used to encrypt a response that is sent in reply to the challenge. Additional permuting mechanisms may be used to further obfuscate the response.

Abstract: System and method for performing correlation analysis. A program that includes multiple program structures and one or more data objects is stored. Each data object is shared by at least two of the program structures. For each program structure, decomposition effects on each of the data objects shared by the program structure resulting from each of a respective one or more optimizing transforms applied to the program structure are analyzed. One or more groups of correlated structures are determined based on the analyzing. Each group includes two or more program structures that share at least one data object, and at least one optimizing transform that is compatible with respect to the two or more program structures and the shared data object. For at least one group, the at least one optimizing transform is usable to transform the two or more program structures to meet a specified optimization objective.

Abstract: System and method for performing correlation analysis. A program that includes multiple program structures and one or more data objects is stored. Each data object is shared by at least two of the program structures. For each program structure, decomposition effects on each of the data objects shared by the program structure resulting from each of a respective one or more optimizing transforms applied to the program structure are analyzed. One or more groups of correlated structures are determined based on the analyzing. Each group includes two or more program structures that share at least one data object, and at least one optimizing transform that is compatible with respect to the two or more program structures and the shared data object. For at least one group, the at least one optimizing transform is usable to transform the two or more program structures to meet a specified optimization objective.

Abstract: System and method for performing correlation analysis. A program that includes multiple program structures and one or more data objects is stored. Each data object is shared by at least two of the program structures. For each program structure, decomposition effects on each of the data objects shared by the program structure resulting from each of a respective one or more optimizing transforms applied to the program structure are analyzed. One or more groups of correlated structures are determined based on the analyzing. Each group includes two or more program structures that share at least one data object, and at least one optimizing transform that is compatible with respect to the two or more program structures and the shared data object. For at least one group, the at least one optimizing transform is usable to transform the two or more program structures to meet a specified optimization objective.

Abstract: System and method for performing correlation analysis. A program that includes multiple program structures and one or more data objects is stored. Each data object is shared by at least two of the program structures. For each program structure, decomposition effects on each of the data objects shared by the program structure resulting from each of a respective one or more optimizing transforms applied to the program structure are analyzed. One or more groups of correlated structures are determined based on the analyzing. Each group includes two or more program structures that share at least one data object, and at least one optimizing transform that is compatible with respect to the two or more program structures and the shared data object. For at least one group, the at least one optimizing transform is usable to transform the two or more program structures to meet a specified optimization objective.

Abstract: An electronic asymmetric unclonable function applied to an electronic system being evaluated includes an electronic system and an AUF array electronically associated with the electronic system. The AUF array includes a plurality of non-identical cells. Each of the non-identical cells includes a test element representing a characteristic of the electronic system being evaluated and a measurement device evaluating the test element. A comparison unit processes an output of the measurement device to provide a multi-bit output value representing a magnitude of differences.

Abstract: An electronic asymmetric unclonable function applied to an electronic system being evaluated includes an electronic system and an AUF array electronically associated with the electronic system. The AUF array includes a plurality of non-identical cells. Each of the non-identical cells includes a test element representing a characteristic of the electronic system being evaluated and a measurement device evaluating the test element. A comparison unit processes an output of the measurement device to provide a multi-bit output value representing a magnitude of differences.

Abstract: A self-modifying FPGA system includes an FPGA and a configuration memory coupled to the FPGA for providing the FPGA with configuration data including SAFE configuration data and dormant configuration data. The SAFE configuration data is initially loaded to the FPGA and the FPGA is configured to a safe operating mode. Upon a determination to proceed to a next step of self modification, dormant configuration data contained in the configuration memory is loaded into the FPGA and the FPGA is configured to a secure operating mode.

Abstract: A system employs physical unclonable functions of an integrated circuit for detecting integrated circuits and protecting products and technology from integrated circuits which have been subject to tampering, stressing and replacement, and counterfeit components. The system includes a sensor detecting a characteristic impedance generated as a result of controlled access to a memory device of the integrated circuit. The characteristic impedance is applied in the creation of a discrimination matrix of values based on electrical interface signals for the integrated circuit. The sensor includes a ring oscillator and associated monitoring components. The ring oscillator is composed of the memory device of the integrated circuit and a sensory circuitry, wherein changes in a frequency generated by the ring oscillator is indicative of changes in circuitry.

Abstract: An electronic asymmetric unclonable function applied to an electronic system being evaluated includes an electronic system and an AUF array electronically associated with the electronic system. The AUF array includes a plurality of non-identical cells. Each of the non-identical cells includes a test element representing a characteristic of the electronic system being evaluated and a measurement device evaluating the test element. A comparison unit processes an output of the measurement device to provide a multi-bit output value representing a magnitude of differences.

Abstract: An electronic asymmetric unclonable function applied to an electronic system being evaluated includes an electronic system and an AUF array electronically associated with the electronic system. The AUF array includes a plurality of non-identical cells. Each of the non-identical cells includes a test element representing a characteristic of the electronic system being evaluated and a measurement device evaluating the test element. A comparison unit processes an output of the measurement device to provide a multi-bit output value representing a magnitude of differences.

Abstract: A method for combating counterfeiting and tampering of integrated circuits includes the steps providing a programmable logic device, the programmable logic device including an arithmetic circuit implemented into the substrate, and constructing an arithmetic feedback oscillator using the arithmetic circuit. The step of constructing the arithmetic feedback oscillator includes incorporating a feedback loop into the arithmetic circuit and feeding output bits back into an input of the arithmetic circuit. The method also includes the step of selecting input values producing repeating values in a lesser order bit of a product of the arithmetic circuit when first and second input are applied to the arithmetic circuit and monitoring the lesser order bit and determining a predicted pattern.

Abstract: System and method for approximating a system. A multi-parameter representation of a family of systems is stored. An embedding of the family into an abstract geometrical continuous space with a metric and defined by the parameters is determined. Coordinates of the space specify values for the parameters of systems of the family. The space includes a grid of points representing respective discrete approximations of the systems. A first point corresponding to a desired instance of a system is determined. The first point's coordinates specify values for the parameters of the instance. The space is sampled using a mapping of a well-distributed point set from a Euclidean space of the parameters to the abstract space. A nearest discrete point to the first point is determined which specifies values for parameters for an optimal discrete approximation of the desired instance, which are useable to implement the discrete approximation of the desired instance.

Abstract: A method for combating counterfeiting and tampering of integrated circuits includes the steps providing a programmable logic device, the programmable logic device including an arithmetic circuit implemented into the substrate, and constructing an arithmetic feedback oscillator using the arithmetic circuit. The step of constructing the arithmetic feedback oscillator includes incorporating a feedback loop into the arithmetic circuit and feeding output bits back into an input of the arithmetic circuit. The method also includes the step of selecting input values producing repeating values in a lesser order bit of a product of the arithmetic circuit when first and second input are applied to the arithmetic circuit and monitoring the lesser order bit and determining a predicted pattern.