Patents by Inventor James M. McKiernan

James M. McKiernan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enhanced reverse transcriptase polymerase chain assay to detect MN in patients with renal cell carcinoma
    Patent number: 6451532
    Abstract: This invention provides methods of: (a) diagnosing; (b) determining the stage of; and (c) monitoring the effect of a therapeutic intervention for a renal cell carcinoma in a human subject which comprises detecting the expression of the MN gene. In one embodiment, the method is directed to detection of the renal cell carcinoma known as clear cell carcinoma. In another embodiment, the method is used as a peripheral blood assay. In another embodiment, the method is a polymerase chain reaction assay for amplifying and detecting the presence of the cDNA molecule encoding the MN protein.
    Type: Grant
    Filed: October 15, 1999
    Date of Patent: September 17, 2002
    Assignees: The Trustees of Columbia University in the City of New York, Cornell Research Foundation, Inc.
    Inventors: James M. McKiernan, Ihor S. Sawczuk, Ralph Buttyan, Neil H. Bander
  • Enhanced reverse transcriptase polymerase chain assay to detect MN in patients with renal cell carcinoma
    Patent number: 6087098
    Abstract: This invention provides methods of (a) diagnosing; (b) determining the stage of; and (c) monitoring the effect of a therapeutic intervention for a renal cell carcinoma in a human subject which comprises detecting the expression of the MN gene. In one embodiment, the method is directed to detection of the renal cell carcinoma known as clear cell carcinoma. In another embodiment, the method is used as a peripheral blood assay. In another embodiment, the method is a polymerase chain reaction assay for amplifying and detecting the presence of the cDNA molecule encoding the MN protein.
    Type: Grant
    Filed: April 15, 1997
    Date of Patent: July 11, 2000
    Assignees: The Trustees of Columbia University in the City of New York, Cornell Research Foundation, Inc.
    Inventors: James M. McKiernan, Ihor S. Sawczuk, Ralph Buttyan, Neil H. Bander