Abstract: Compounds of Formula I or pharmaceutically acceptable salts or esters thereof capable of binding to and modulating the activity of a stimulator of interferon genes (STING) protein are provided. Methods involving compounds of Formula I as effective modulators of STING are also provided.

Abstract: Compounds of Formula I or pharmaceutically acceptable salts or esters thereof capable of binding to and modulating the activity of a stimulator of interferon genes (STING) protein are provided. Methods involving compounds of Formula I as effective modulators of STING are also provided.

Abstract: Compounds of Formula I or pharmaceutically acceptable salts or esters thereof capable of binding to and modulating the activity of a stimulator of interferon genes (STING) protein are provided. Methods involving compounds of Formula I as effective modulators of STING are also provided.

Abstract: Compounds of Formula I or pharmaceutically acceptable salts or esters thereof capable of binding to and modulating the activity of a stimulator of interferon genes (STING) protein are provided. Methods involving compounds of Formula I as effective modulators of STING are also provided.

Abstract: Compounds of Formula I or pharmaceutically acceptable salts or esters thereof capable of binding to and modulating the activity of a stimulator of interferon genes (STING) protein are provided. Methods involving compounds of Formula I as effective modulators of STING are also provided.

Abstract: An athletic shoe is provided having a plurality of interchangeable soles which may be attached or removed by a push-button spring release mechanism located on the heel. This push-button element, when actuated, permits the interchangeable sole to be removed or attached. In the preferred embodiment, this push-button element causes a pair of flexible spring type capture elements to flex, permitting a pin member located on the sole to either be inserted or withdrawn. The shoe and sole have a plurality of other novel interfitting elements and mechanisms which permit the sole to be securely affixed to the shoe as well as prevent any movement of the sole with respect to the shoe. Shoe soles may be provided which have a variety of cleats, treads or other designs which may be utilized for diverse uses such as sport or leisure. By utilizing the invention, one may employ one shoe for a variety of athletic or other activities by simply attaching the desired sole.

Abstract: An improved groove-type roller for use in combination with a mower of the type including a cutting reel is disclosed. The groove-type roller includes a roller body having contacting edges separated by inner recesses wherein the contacting edges and inner recesses are designed so that no portion of the surface of the roller body opposes another portion of the surface of the roller body. The lifting roller further includes first and second sealed bearings mounted to first and second ends of the roller body. An elongated shaft extends through the entire length of the roller body and engages each of the first and second sealed bearings. The shaft is provided for mounting the groove-type roller to the mower. The sealed bearings are provided for interfacing the shaft with the roller body to permit rotation of the roller body with respect to the shaft. Preferably, the roller body is anodized treated aluminum to provide a hard surface that will resist mushrooming.

Abstract: An improved circuit board material having a support layer, an electrical resistance layer and a conductive layer. The circuit board material has a resistance of at least about 500 ohms/square. The circuit board material is formed by electro-plating the electrical resistance layer on the conductive layer. The conductive layer is desirably activated prior to electro-deposition of the electrical resistance layer thereon. The conductive layer is activated by contacting with an activating agent such as benzotriazole electrolytic chromate and the like. A preferred electro-plating bath for electro-deposition of the electrical resistance layer comprises about 0.5 mole per liters nickel hypophosphite. The disclosed electro-plating bath functions at ambient temperatures and is effectively temperature independent. Circuit boards can be formed from the circuit board material through a process involving only two etching steps.

Abstract: An improved multilayered circuit board material and process for making that material is disclosed. The material includes an insulating material support layer, an electrical resistance material layer adhering to the support layer, and a conductive material layer adhering to the resistance material layer and in intimate contact with that layer. The electrical resistance material layer comprises electroplated nickel-phosphorous containing up to about 30% by weight of phosphorous; however, no appreciable amounts of sulfur are present within at least the top about ten atomic layers of the electrical resistance material layer. As a result, the stability of the electrical resistance material layer is significantly increased. In addition, the electroplating bath does not contain chloride salts resulting in decreased pitting in the electrical resistance material layer.

Abstract: A multilayered circuit board material is disclosed. The material includes an insulating material support layer, an electrical resistance material layer adhering to the support layer, and a conductive material layer adhering to the resistance material layer and in intimate contact with that layer. The electrical resistance material layer is formed from electroplated nickel-phosphorous containing up to about 30% by weight of phosphorous; however, no appreciable amounts of sulfur are present within at least the top about ten atomic layers of the electrical resistance material layer. As a result, the stability of the electrical resistance material layer is significantly increased. In addition, the electroplating bath does not contain chloride salts resulting in decreased pitting in the electrical resistance material layer.

Abstract: An improved telephone monitoring and recording apparatus is described. The monitoring and recording apparatus is connected in parallel with one or more telephones for the purpose of recording in memory and printing out on paper for each call detected, information which is typically: the number dialed, the time and date the call was made, and the duration of call. Other information which is also monitored and recorded in memory is also typically; the station originating the call, the number of rings, whether the destination was `busy` and whether there was a voice communication. These and other similar information requests may be programmed in at installation using a keyboard, and printed out on the printer which is part of the apparatus. The equipment is improved in that it can be used with any telephone set up desired, without modification. It can identify both rotary pulse dialed and "Touch Tone" dialed numbers without manual selection and switching.

Abstract: A novel laminate adapted for use in the manufacture of capacitors comprising layers of microthin pin-hole free electroformed copper bonded together by a thin layer of hardened dielectric material, said bonded surfaces of said microthin copper having first been treated to form thereon a superficial coating of cupric oxide, bonded to the outer surfaces of said microthin copper, layers of self-sustaining copper foil, the bonded surfaces of said copper foil having been passivated under reducing or cathodic conditions in an aqueous solution of chromic oxide to passivate the surface thereof and to render said copper foil peelably removable from said microthin copper.