Patents by Inventor James M. Schaeffer

James M. Schaeffer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Growth hormone secretagogue receptor family
    Publication number: 20030166144
    Abstract: Human, swine and rat growth hormone secretagogue receptors have been isolated, cloned and sequenced. Growth hormone secretagogue receptors are new members of the G-protein family of receptors. The growth hormone secretagogue receptors may be used to screen and identify compounds which bind to the growth hormone secretagogue receptor. Such compounds may be used in the treatment of conditions which occur when there is a shortage of growth hormone, such as observed in growth hormone deficient children, elderly patients with musculoskeletal impairment and recovering from hip fracture and osteoporosis.
    Type: Application
    Filed: November 25, 2002
    Publication date: September 4, 2003
    Applicant: Merck & Co., Inc.
    Inventors: Joseph P. Arena, Doris F. Cully, Scott D. Feighner, Andrew D. Howard, Paul A. Liberator, James M. Schaeffer, Leonardus H. T. Van Der Ploeg
  • Growth hormone secretagogue receptor family
    Patent number: 6531314
    Abstract: Human, swine and rat growth hormone secretagogue receptors have been isolated, cloned and sequenced. Growth hormone secretagogue receptors are new members of the G-protein family of receptors. The growth hormone secretagogue receptors may be used to screen and identify compounds which bind to the growth hormone secretagogue receptor. Such compounds may be used in the treatment of conditions which occur when there is a shortage of growth hormone, such as observed in growth hormone deficient children, elderly patients with musculoskeletal impairment and recovering from hip fracture and osteoporosis.
    Type: Grant
    Filed: June 3, 1998
    Date of Patent: March 11, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Joseph P. Arena, Doris F. Cully, Scott D. Feighner, Andrew D. Howard, Paul A. Liberator, James M. Schaeffer, Leonardus H. T. Van Der Ploeg
  • Radiolabeled growth hormone secretagogue
    Patent number: 5830433
    Abstract: The present invention is directed to ?.sup.35 S!-N-?1(R)-?(1,2-dihydro-1-methanesulfonylspiro?3H-indole-3,4'-piperidin!- 1'-yl)carbonyl!-2-(phenylmethyloxy)ethyl!-2-amino-2-methylpropanamide, and pharmaceutically acceptable salts thereof. This ?.sup.35 S! radioligand is useful in identifying and characterizing cellular receptors which play a role in the activity of growth hormone secretatogogues. In addition, this ?.sup.35 S! radioligand is useful in assays which test compounds for growth hormone secretagogue activity.
    Type: Grant
    Filed: December 17, 1996
    Date of Patent: November 3, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Dennis C. Dean, David G. Melillo, Ravi Nargund, Leonardus Van Der Ploeg, Sheng-Shung Pong, James M. Schaeffer, Roy G. Smith
  • Bioluminescent assay reagent and method
    Patent number: 4665022
    Abstract: Reagent for immunoassay, ligand binding assay and ligand receptor assay in which luciferin is covalently bonded to a molecule having biological activity for bonding to a particular biologically active group of a material and method in which the luciferin and biologically active molecule conjugate is added to a material having a group for combination with the biological activity of the conjugated molecule, the mixture is incubated to bond the material to the reagent through the biological activity and the product of the bonding is reacted with luciferase to produce bioluminescence having intensity dependent on the concentration of the material being assayed.
    Type: Grant
    Filed: February 17, 1984
    Date of Patent: May 12, 1987
    Assignee: The Regents of the University of California
    Inventors: James M. Schaeffer, Aaron J. Hsueh