Patents by Inventor James M. Schlatter

James M. Schlatter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tetrapeptide amides in the treatment of hypertension
    Patent number: 4722922
    Abstract: The invention relates to tetrapeptides of the formula I: ##STR1## which are useful as renin inhibition/antihypertensive agents.
    Type: Grant
    Filed: January 22, 1985
    Date of Patent: February 2, 1988
    Assignee: G. D. Searle & Co.
    Inventors: Donald W. Hansen, Jr., David A. Jones, Jr., Robert H. Mazur, James M. Schlatter
  • Enkephalin analogs
    Patent number: 4603121
    Abstract: The invention relates to novel enkephalin analogs of the formula: ##STR1## which are useful as analgesic agents.
    Type: Grant
    Filed: September 14, 1984
    Date of Patent: July 29, 1986
    Assignee: G. D. Searle & Co.
    Inventors: Donald W. Hansen, Jr., David A. Jones, Jr., Robert H. Mazur, James M. Schlatter
  • Enkephalin analogs
    Patent number: 4495178
    Abstract: The invention relates to novel enkephalin analogs of the formula: ##STR1## which are useful as analgesic agents.
    Type: Grant
    Filed: October 6, 1983
    Date of Patent: January 22, 1985
    Assignee: G. D. Searle & Co.
    Inventors: Donald W. Hansen, Jr., David A. Jones, Jr., Robert H. Mazur, James M. Schlatter
  • Methionine.sup.5 -enkephalin sulfoxides and sulfones
    Patent number: 4144228
    Abstract: Methionine.sup.5 -enkephalin sulfoxides and sulfones having agonist activity at opiate receptors are disclosed herein. These sulfoxides and sulfones are useful as analgesics, non-addicting narcotic antagonists and anti-diarrheal agents.
    Type: Grant
    Filed: May 7, 1976
    Date of Patent: March 13, 1979
    Assignee: G. D. Searle & Co.
    Inventors: David A. Jones, Jr., James M. Schlatter
  • Method for cleaving the peptide-resin bond in solid phase peptide synthesis by hydrogenolysis
    Patent number: 4113713
    Abstract: An improved process for cleaving peptides bound to a polymer by way of a benzylester linkage during solid phase peptide synthesis, the improvement comprising hydrogenolysis of said linkage by catalytic hydrogenation using a palladium (II) salt with a weak acid anion as the catalyst.
    Type: Grant
    Filed: June 16, 1977
    Date of Patent: September 12, 1978
    Assignee: G. D. Searle & Co.
    Inventors: James M. Schlatter, Owen Goodmonson
  • 4-Substituted enkephalin derivatives
    Patent number: 4092304
    Abstract: Analogs of methionine.sup.5 -enkephalin and leucine.sup.5 -enkephalin wherein the L-phenylalanyl residue in position 4 has been substituted by various other amino acid residues are disclosed herein. These analogs exhibit agonist activity at opiate receptor sites and are thus useful as analgesics, non-addicting narcotic antagonists and anti-diarrheal agents.
    Type: Grant
    Filed: August 9, 1976
    Date of Patent: May 30, 1978
    Assignee: G. D. Searle & Co.
    Inventors: David A. Jones, Jr., James M. Schlatter, Richard A. Mikulec, Judith A. Reuter
  • Fragments of secretin
    Patent number: 4086220
    Abstract: Fragments of secretin are disclosed herein. The compounds disclosed contain the amino acid fragments of secretin having the 1-15 amino acid sequence through those having the 1-19 amino acid sequence. Also disclosed are the above secretin fragments having a protecting group on the first amino acid. The compounds are useful as gastric antisecretory agents.
    Type: Grant
    Filed: August 9, 1976
    Date of Patent: April 25, 1978
    Assignee: G. D. Searle & Co.
    Inventor: James M. Schlatter
  • 2 AND 3-SUBSTITUTED ENKEPHALINS
    Patent number: 4028319
    Abstract: Analogs of enkephalin having agonist activity at opiate receptors are disclosed herein. These analogs are useful as analgesics, non-addicting narcotic antagonists and anti-diarrheal agents.
    Type: Grant
    Filed: May 7, 1976
    Date of Patent: June 7, 1977
    Assignee: G. D. Searle & Co.
    Inventors: David A. Jones, Jr., James M. Schlatter, Richard A. Mikulec, Judith A. Reuter, Robert H. Mazur
  • 3-Amino-N-substituted succinamic acids
    Patent number: 4025551
    Abstract: 3-Amino-N-substituted succinamic acids, prepared by coupling of a protected L-aspartic acid derivative with the appropriate amine followed by cleavage of the protecting groups, are potent sweetening agents and also exhibit pharmacological, e.g. anti-inflammatory, properties.
    Type: Grant
    Filed: December 22, 1975
    Date of Patent: May 24, 1977
    Assignee: G. D. Searle & Co.
    Inventors: Arthur H. Goldkamp, Robert H. Mazur, James M. Schlatter
  • 3-Amino-N-substituted succinamic acids and intermediates thereto
    Patent number: 4011260
    Abstract: The above-captioned compounds, prepared by coupling of a protected L-aspartic acid derivative with the appropriate amine followed by cleavage of the protecting groups, are potent sweetening agents and exhibit also pharmacological, e.g. anti-inflammatory, properties.
    Type: Grant
    Filed: February 14, 1974
    Date of Patent: March 8, 1977
    Assignee: G. D. Searle & Co.
    Inventors: Arthur H. Goldkamp, Robert H. Mazur, James M. Schlatter
  • Optical resolution of alkyl esters of DL-phenylalanine
    Patent number: 3983162
    Abstract: Treatment of an alkyl ester of DL-phenylalanine with an N-acyl-D-phenylalanine results in the formation of the corresponding insoluble salt of L-phenylalanine alkyl ester and N-acyl-D-phenylalanine. The salt is purified by recrystallization in the presence of an added quantity of the alkyl ester of DL-phenylalanine or the alkyl ester of L-phenylalanine. The isolated, purified salt is decomposed to afford the desired L-phenylalanine alkyl ester, which is an important starting material in the preparation of artificial sweetening agents.
    Type: Grant
    Filed: January 2, 1975
    Date of Patent: September 28, 1976
    Assignee: G. D. Searle & Co.
    Inventor: James M. Schlatter