Abstract: A calibration reference for a multipass Raman analysis system, wherein a combination excitation and collection beam passes through a focal point F0 within a sample volume multiple times, is provided. The calibration reference includes a body of material having a known spectral response when illuminated by the combination excitation and collection beam. The size or shape of the body is selected or modified to keep the focal point at F0 within the body when the body is positioned within the sample volume for calibration purposes.

Abstract: A computer-implemented method of object enhancement in endoscopy images includes capturing an image of an object within a surgical operative site via an imaging device, determining a size of the object based on the captured image of the object, displaying the captured image of the object, and displaying on the displayed captured image of the object a representation of the determined size of the object.

Abstract: A system for delivering two types of particles to a target within the body of a patient. A proton beam therapy system produces a beam of protons that is directed from a nozzle towards a target isocenter located within the body of a patient. The beam of protons can pass directly to the patient or pass through a neutron source comprised of a plate of neutron-rich material. Collisions between some of the protons and neutrons cause neutrons to be emitted from the material thereby generating a multiple particle beam comprised of both protons and neutrons. Preferably, the neutrons comprise only a small percent of the total particles in the beam. In the preferred embodiment, the neutron source is comprised of a plate of Beryllium that is interposed between the nozzle and the patient.

Abstract: Accurate and repeatable patient alignment with a charged-particle beam of a radiation beam therapy system, such as a proton beam delivery system, is provided. The patient is immobilized within a form-fit patient pod. Reference radiographs are prepared that are used for repositioning the patient within the pod on subsequent occasions. CT scan data of a particular tissue volume of interest, such as a region of the patient wherein a cancerous tumor is located, is obtained while the patient remains in the pod. The CT scan data is used to prepare a treatment plan for the patient. The treatment plan includes identifying an isocenter within the tissue volume at which the beam is to be directed from a selected angle(s). A computer simulation of the treatment plan may be performed to optimize the treatment plan, i.e., to help identify the number of beams and treatment angles that will best irradiate the cancerous cells.

Abstract: A whole-body patient positioning and repositioning support for fixedly securing a patient in an original position during radiation treatment and for repositioning the patient to the same original position for subsequent radiation treatments. The support includes a foamed-in-place mold within a disposable plastic shell carrying a grid of radio-opaque members for generating a patient registration grid on X-rays for use in the evaluation and adjusting of the position of the patient to the original position using a sheet or straps between the patient and the mold.