Patents by Inventor James M. Wilson

James M. Wilson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240127943
    Abstract: A pathogen detection and display system is configured to discover and display the location of substances of interest, particularly pathogens that can spread infection. The detection and display system can be used in healthcare facilities on surfaces, medical equipment and devices, patients, and staff, for example.
    Type: Application
    Filed: December 15, 2023
    Publication date: April 18, 2024
    Applicant: Cardeya Corporation
    Inventors: Charles R. Sperry, Lawrence J. Pillote, Vincent A. Piucci, Dennis F. McNamara, JR., James M. Wilson, III, Lisa Ruth Stowe, Brett M. Sitzlar, Barbara A. Piucci, David C. Chase
  • Publication number: 20240117322
    Abstract: A recombinant adeno-associated virus (rAAV) vector comprising an AAVhu68 capsid produced in a production system comprising a nucleotide sequence of SEQ ID NO: 1, or a sequence at least 75% identical thereto which encodes SEQ ID NO:2. The AAVhu68 capsid comprises subpopulations of highly deamidated asparagine residues in asparagine-glycine pairs in the amino acid sequence of SEQ ID NO: 2. Also provided are compositions containing the rAAV and uses thereof. Additionally, rAAV having an engineered AAV capsid comprising at least one subpopulation of vp1 or vp2 proteins having a Val at amino acid position 157 with reference to the AAVhu68 vp1 numbering are provided.
    Type: Application
    Filed: October 11, 2023
    Publication date: April 11, 2024
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: James M. Wilson, Qiang Wang, April Tepe, Kevin Turner
  • Publication number: 20240117378
    Abstract: A method of correcting singletons in a selected AAV sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected AAV is provided. This method involves altering one or more singletons in the parental AAV capsid to conform the singleton to the amino acid in the corresponding position(s) of the aligned functional AAV capsid sequences.
    Type: Application
    Filed: June 30, 2023
    Publication date: April 11, 2024
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Luk VANDENBERGHE, Guangping GAO, James M. WILSON
  • Publication number: 20240115733
    Abstract: Provided herein are polynucleotide sequences encoding human acid sphingomyelinase (SMPD1) and expression cassettes containing these coding sequences. Also provided are vectors, such as recombinant adeno-associated virus (rAAV) vectors having vector genomes that include an engineered SMPD1 coding sequence operably linked to one or more regulatory sequences. Further, compositions containing these expression cassettes and rAAV are provided, as well as methods for the use of these compositions for treatment of Niemann Pick Type A disease.
    Type: Application
    Filed: February 1, 2022
    Publication date: April 11, 2024
    Inventors: James M. WILSON, Juliette HORDEAUX, Ting YU
  • Publication number: 20240118790
    Abstract: A computer readable media, a method, and a system registering a third party application providing an available communication system between a local user and a remote user identity, storing information related to the available communication system in a first database, obtaining contact information for the remote user identity from the third party application, determining a communication type for the third party application, pairing the remote user identity with a contact, and updating a graphical representation of contact information.
    Type: Application
    Filed: September 25, 2023
    Publication date: April 11, 2024
    Inventors: Jeffrey D. Harris, Joseph H. Engel, Keith Stattenfield, John-Peter E. Cafaro, Colter S. Reed, Bruce M. Stadnyk, James C. Wilson, David A. McLeod, Alexander B. Brown
  • Publication number: 20240108399
    Abstract: An apparatus including a body, a shaft assembly extending distally from the body, and an end effector configured to grasp and transmit RF energy to the tissue. The end effector includes a first jaw having a first tissue grasping feature and a second jaw. The second jaw is pivotably coupled to the first jaw between an open position, a partially closed position, and a closed position. The second jaw includes a proximal taper having a proximal electrode surface, a distal taper including a distal electrode surface, and a juncture between the proximal and distal electrode surface. The juncture is spaced further from the first tissue grasping feature compared to the proximal and distal end while the second jaw is in the partially closed position. The proximal and distal electrode surface deform to define a gap with the first tissue grasping feature while in the closed position.
    Type: Application
    Filed: December 14, 2023
    Publication date: April 4, 2024
    Inventors: James M. Wilson, Randolph C. Stewart, Jason R. Lesko, Gregory A. Trees, Kristen L. D'Uva
  • Patent number: 11941764
    Abstract: A computer system displays a representation of a field of view of the one or more cameras, including a representation of a portion of a three-dimensional physical environment that is in the field of view of the one or more cameras. The computer system receives a request to add a first virtual effect to the displayed representation of the field of view of the one or more cameras. In response to receiving the request to add the first virtual effect to the displayed representation of the field of view of the one or more cameras and in accordance with a determination that the first virtual effect requires a scan of the physical environment, the computer system initiates a scan of the physical environment to detect one or more features of the physical environment and displays a user interface that indicates a progress of the scan of the physical environment.
    Type: Grant
    Filed: April 13, 2022
    Date of Patent: March 26, 2024
    Assignee: APPLE INC.
    Inventors: Andrew L. Harding, James A. Queen, Joseph-Alexander P. Weil, Joanna M. Newman, Ron A. Buencamino, Richard H. Salvador, Fernando Garcia, Austin T. Tamaddon, Omid Khalili, Scott W. Wilson, Thomas H. Smith, III
  • Publication number: 20240082288
    Abstract: A method of altering the targeting and/or cellular uptake efficiency of an adeno-associated virus (AAV) viral vector having a capsid containing an AAV9 cell surface binding domain is described. The method involves modifying a clade F cell surface receptor which comprises a glycan having a terminal sialic acid residue and a penultimate ?-galactose residue. The modification may involve retargeting the vector by temporarily functionally ablate AAV9 binding in a subset of cells, thereby redirecting the vector to another subset of cells. Alternatively, the modification may involve increasing cellular update efficiency by treating the cells with a neuraminidase to expose cell surface ?-galactose. Also provided are compositions containing the AAV9 vector and a neuraminidase. Also provided is a method for purifying AAV9 using ?-galactose linked to solid support.
    Type: Application
    Filed: August 15, 2023
    Publication date: March 14, 2024
    Inventors: James M. Wilson, Christie L. Bell, Luc H. Vandenberghe
  • Publication number: 20240081011
    Abstract: Textured cover assemblies for electronic devices are disclosed. The textured cover assemblies may provide a combination of optical and tactile properties to the electronic devices. In some cases, a textured cover assembly may be provided over decorative coating.
    Type: Application
    Filed: November 10, 2023
    Publication date: March 7, 2024
    Inventors: Andi M. Limarga, James R. Wilson, Matthew S. Rogers, Que Anh S. Nguyen, Bijumon Varkey
  • Publication number: 20240050521
    Abstract: A recombinant adeno-associated virus (rAAV) comprising an AAV capsid and a vector genome comprising a frataxin gene is provided. Also provided is a composition containing an effective amount of rAAV to ameliorate symptoms of Freidreich's ataxia, including, e.g., reduction in progression towards neurocognitive decline and/or cardiomyopathy.
    Type: Application
    Filed: January 11, 2022
    Publication date: February 15, 2024
    Inventors: James M. Wilson, Christian Hinderer, Nimrod Miller
  • Patent number: 11890329
    Abstract: A co-therapeutic regimen comprising AAV9-mediated intrathecal/intracisternal and/or systemic delivery of an expression cassette containing a hIDUA gene and two or more immunosuppressants is provided herein. Also provided are methods useful for treating hIDUA deficiency (MPSI) and the symptoms associated with Hurler, Hurler-Scheie and Scheie syndromes.
    Type: Grant
    Filed: July 5, 2018
    Date of Patent: February 6, 2024
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Christian Hinderer, James M. Wilson
  • Publication number: 20240024507
    Abstract: Provided herein are compositions including targeting peptides linked thereto or inserted in a targeting protein of a recombinant vector having at least one exogenous peptide comprising an amino acid sequence of N-x-(T/I/V/A)-(K/R) (SEQ ID NO: 47). Compositions providing such conjugates, targeting peptides, or recombinant vectors having a mutant capsid or envelope protein are provided as are uses thereof.
    Type: Application
    Filed: December 1, 2021
    Publication date: January 25, 2024
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: James M. Wilson, Joshua Joyner Sims, Yuan Yuan
  • Publication number: 20240024510
    Abstract: A suspension useful for AAV9-mediated intrathecal/intracisternal and/or systemic delivery of an expression cassette containing a hIDUA gene is provided herein. Also provided are methods and kits containing these vectors and compositions useful for treating MPSI and the symptoms associated with Hurler, Hurler-Scheie and Scheie syndromes.
    Type: Application
    Filed: September 27, 2023
    Publication date: January 25, 2024
    Applicant: The Trustees of the University of Pennsylania
    Inventors: Christian Hinderer, James M. Wilson
  • Publication number: 20240016903
    Abstract: A co-therapeutic regimen comprising AAV9-mediated intrathecal/intracisternal and/or systemic delivery of an expression cassette containing a hIDS gene and two or more immunosuppressants is provided herein. Also provided are methods and kits containing these vectors and compositions useful for treating Hunter syndrome and the symptoms associated with Hunter syndrome.
    Type: Application
    Filed: August 17, 2023
    Publication date: January 18, 2024
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Christian Hinderer, James M. Wilson
  • Publication number: 20240010699
    Abstract: Compositions and methods for treating diabetes in a canine are provided. A viral vector is provided which includes a nucleic acid molecule comprising a sequence encoding a canine insulin polypeptide.
    Type: Application
    Filed: November 4, 2021
    Publication date: January 11, 2024
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: James M. Wilson, Christian Hinderer, Makoto Horiuchi
  • Publication number: 20240009327
    Abstract: Provided herein is a recombinant AAV (rAAV) comprising an AAV capsid and a vector genome packaged therein, wherein the vector genome comprises an AAV 5? inverted terminal repeat (ITR), an engineered nucleic acid sequence encoding a functional human N-acetyl-alpha-glucosaminidase (hNAGLU), a regulatory sequence which direct expression of hNAGLU in a target cell, and an AAV 3? ITR. Also provided is a pharmaceutical composition comprising a rAAV as described herein in a formulation buffer, and a method of treating a human subject diagnosed with MPS IIIB.
    Type: Application
    Filed: July 10, 2023
    Publication date: January 11, 2024
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: James M. Wilson, Christian Hinderer, Juliette Hordeaux
  • Patent number: 11865187
    Abstract: A composition comprising at least one AAV vector formulated for central nervous system delivery is described. The composition comprises at least one expression cassette which contains sequences encoding an anti-neoplastic immunoglobulin construct for delivery to the brain operably linked to expression control sequences therefor and a pharmaceutically acceptable carrier. The anti-neoplastic immunoglobulin construct may be an immunoglobulin modified to have decreased or no measurable affinity for neonatal Fc receptor (FcRn). Also provided are methods of using these constructs in preparing pharmaceutical compositions and uses thereof in anti-neoplastic regimens, particularly for primary and/or metastatic cancers of the brain.
    Type: Grant
    Filed: August 6, 2020
    Date of Patent: January 9, 2024
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: James M. Wilson, William Thomas Rothwell, Christian Hinderer
  • Publication number: 20240000974
    Abstract: Compositions and regimens useful in treating hemophilia A are provided. The compositions include recombinant adeno-associated virus (rAAV) with a transthyretin enhancer and promoter driving expression of a human Factor VIII.
    Type: Application
    Filed: August 8, 2023
    Publication date: January 4, 2024
    Inventors: Lili Wang, James M. Wilson, Jenny Agnes Sidrane
  • Patent number: 11862329
    Abstract: A pathogen detection and display system is configured to discover and display the location of substances of interest, particularly pathogens that can spread infection. The detection and display system can be used in healthcare facilities on surfaces, medical equipment and devices, patients, and staff, for example.
    Type: Grant
    Filed: July 7, 2020
    Date of Patent: January 2, 2024
    Assignee: Cardeya Corporation
    Inventors: Charles R. Sperry, Lawrence J. Pillote, Vincent A. Piucci, Dennis F. McNamara, Jr., James M. Wilson, III, Lisa Ruth Stowe, Brett M. Sitzlar, Barbara A. Piucci, David C. Chase
  • Patent number: 11857247
    Abstract: An apparatus including a body, a shaft assembly extending distally from the body, and an end effector configured to grasp and transmit RF energy to the tissue. The end effector includes a first jaw having a first tissue grasping feature and a second jaw. The second jaw is pivotably coupled to the first jaw between an open position, a partially closed position, and a closed position. The second jaw includes a proximal taper having a proximal electrode surface, a distal taper including a distal electrode surface, and a juncture between the proximal and distal electrode surface. The juncture is spaced further from the first tissue grasping feature compared to the proximal and distal end while the second jaw is in the partially closed position. The proximal and distal electrode surface deform to define a gap with the first tissue grasping feature while in the closed position.
    Type: Grant
    Filed: July 17, 2020
    Date of Patent: January 2, 2024
    Assignee: Cilag GmbH International
    Inventors: James M. Wilson, Randolph C. Stewart, Jason R. Lesko, Gregory A. Trees, Kristen L. D'Uva