Abstract: This invention relates to compounds of formula (I) and methods of treatment using the compounds. The invention also relates to processes and methods for producing the compounds of the invention. The compounds of the invention are modulators of Factor XII (e.g. Factor XIIa). In particular, the compounds are inhibitors of Factor XIIa and may be useful as anticoagulants.

Abstract: A folding knife includes a handle and a blade rotatably connected to the handle, the blade rotatable between a closed position and an opened position about a blade axis. A finger tab is useable to rotate the blade from the closed position to the opened position, the finger tab rotatably connected to the blade and rotatable between a retracted position and an extended position about a tab axis parallel to the blade axis. A torsion spring biases the finger tab toward the retracted position.

Abstract: A folding knife includes a lockbar for automatically locking a knife blade in an opened position relative to a handle. A puck attached to the lockbar is configured to engage a tang of the blade to lock the blade in an open position relative to the handle.

Abstract: A folding knife includes a handle assembly, a blade, and a secondary tool. The blade is pivotally connected to the handle assembly and is configured to pivot from a closed position to an opened position. The secondary tool is pivotally connected to the handle assembly and is configured to pivot from a closed position to an opened position. The secondary tool includes a locking member that traps the blade in the closed position when the secondary tool is in the opened position but allows the blade to pivot to the opened position when the secondary tool is in the closed position.

Abstract: A folding knife includes a lockbar for automatically locking a knife blade in an opened position relative to a handle. A puck attached to the lockbar is configured to engage a tang of the blade to lock the blade in an open position relative to the handle.

Abstract: A folding knife includes a handle, a blade pivotably connected to the handle, and a lockbar for locking the blade in an open position relative to the handle. The lockbar and the handle are separate pieces. The handle includes a pocket into which at least a portion of the lockbar is fit.

Abstract: A folding knife includes a handle assembly, a blade, and a secondary tool. The blade is pivotally connected to the handle assembly and is configured to pivot from a closed position to an opened position. The secondary tool is pivotally connected to the handle assembly and is configured to pivot from a closed position to an opened position. The secondary tool includes a locking member that traps the blade in the closed position when the secondary tool is in the opened position but allows the blade to pivot to the opened position when the secondary tool is in the closed position.

Abstract: A folding knife includes a handle, a blade pivotably connected to the handle, and a lockbar for locking the blade in an open position relative to the handle. The lockbar and the handle are separate pieces. The handle includes a pocket into which at least a portion of the lockbar is fit.