Patents by Inventor James Malecha

James Malecha has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9045440
    Abstract: Disclosed herein are new compounds of desazadesferrothiocin polyether (DADFT-PE) analogs, as well as pharmaceutical compositions comprising them and their application as metal chelation agents for the treatment of disease. Methods of chelation of iron and other metals in a human or animal subject are also provided for the treatment of metal overload and toxicity.
    Type: Grant
    Filed: May 4, 2011
    Date of Patent: June 2, 2015
    Assignee: FerroKin Biosciences, Inc.
    Inventor: James Malecha
  • Publication number: 20110275636
    Abstract: Disclosed herein are new compounds of desazadesferrothiocin polyether (DADFT-PE) analogues, as well as pharmaceutical compositions comprising them and their application as metal chelation agents for the treatment of disease. Methods of chelation of iron and other metals in a human or animal subject are also provided for the treatment of metal overload and toxicity.
    Type: Application
    Filed: May 4, 2011
    Publication date: November 10, 2011
    Applicant: FerroKin BioSciences, Inc.
    Inventor: James Malecha
  • Publication number: 20080194681
    Abstract: Disclosed herein are carbonyl compounds of Formula: (I) as described herein. Compounds as modulators of his-tone deacetylase (HDAC), pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
    Type: Application
    Filed: December 9, 2005
    Publication date: August 14, 2008
    Applicant: Kalypsys, Inc.
    Inventors: James Malecha, Stewart Noble, Christian Hassig, Paul Wash, Brandon Wiley, Charles Lawrence, Timothy Hoffman, Celine Bonnefous, NIcholas Smith
  • Publication number: 20080021217
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of Rho kinase for the treatment or prevention of disease.
    Type: Application
    Filed: July 20, 2007
    Publication date: January 24, 2008
    Inventors: Allen Borchardt, Mehmet Kahraman, Travis Cook, Robert Davis, Elizabeth Gardiner, James Malecha, Stewart Noble, Thomas Prins, Michael Sertic, Dana Siegel
  • Publication number: 20080021026
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of Rho kinase for the treatment or prevention of disease.
    Type: Application
    Filed: July 20, 2007
    Publication date: January 24, 2008
    Inventors: Mehmet Kahraman, Allen Borchardt, Travis Cook, Robert Davis, Elisabeth Gardiner, James Malecha, Stewart Noble, Thomas Prins
  • Publication number: 20070190079
    Abstract: The present invention relates to methods of selective modulation of peroxisome proliferator activated receptors (PPARs) over G-protein coupled receptor 40 (GPR40), and the use of therapeutically effective amounts of compounds and pharmaceutical compositions which selectively modulate PPAR over GPR40 for the treatment of diseases in patients in need thereof. The methods disclosed herein are exceptionally useful in treating metabolic diseases whilst avoiding certain side effects common to modulators of PPAR previously disclosed in the art.
    Type: Application
    Filed: March 19, 2007
    Publication date: August 16, 2007
    Applicant: KALYPSYS, INC.
    Inventors: Andrew Shiau, Mark Massari, Guy Oshiro, Ayman Kabakibi, James Malecha, Stewart Noble
  • Publication number: 20070027184
    Abstract: Disclosed herein are sulfonamide compounds of Formula VII as described herein. Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
    Type: Application
    Filed: July 27, 2006
    Publication date: February 1, 2007
    Inventors: James Malecha, Stewart Noble, Brandon Wiley, Timothy Hoffman, Celine Bonnefous, Michael Sertic, Paul Wash, Nicholas Smith, Christian Hassig, Shawn Scranton, Joseph Payne, Jeffery Hager
  • Publication number: 20060258683
    Abstract: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
    Type: Application
    Filed: April 7, 2004
    Publication date: November 16, 2006
    Inventors: Kevin Liu, James Malecha, Stewart Noble, Paul Wash
  • Publication number: 20060205736
    Abstract: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
    Type: Application
    Filed: May 16, 2006
    Publication date: September 14, 2006
    Inventors: Stewart Noble, Guy Oshiro, James Malecha, Cunxiang Zhao, Sergio Duron, Andrew Lindstrom, Andrew Shiau, Boliang Lou, Steven Govek, David Thomas
  • Publication number: 20060167012
    Abstract: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
    Type: Application
    Filed: October 25, 2005
    Publication date: July 27, 2006
    Inventors: Stewart Noble, Guy Oshiro, James Malecha, Cunxiang Zhao, Carmen Robinson, Sergio Duron, Michael Sertic, Andrew Lindstrom, Andrew Shiau, Christopher Bayne, Mehmet Kahraman, Boliang Lou, Steven Govek
  • Publication number: 20060030554
    Abstract: Disclosed herein are carbonyl compounds of having the structural formula: or a pharmaceutically acceptable salt, amide, ester, or prodrug thereof, Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
    Type: Application
    Filed: June 9, 2005
    Publication date: February 9, 2006
    Inventors: James Malecha, Stewart Noble, Christian Hassig, Paul Wash, Brandon Wiley, Charles Lawrence, Timothy Hoffman
  • Publication number: 20060030543
    Abstract: Disclosed herein are carbonyl compounds of Formula I as described herein. Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
    Type: Application
    Filed: June 9, 2005
    Publication date: February 9, 2006
    Inventors: James Malecha, Stewart Noble, Christian Hassig, Paul Wash, Brandon Wiley, Charles Lawrence, Timothy Hoffman
  • Publication number: 20050234046
    Abstract: Aryl sulfonamide and sulfonyl compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
    Type: Application
    Filed: April 7, 2005
    Publication date: October 20, 2005
    Applicant: Kalypsys, Inc.
    Inventors: Cunxiang Zhao, James Malecha, Stewart Noble, Sergio Duron, Andrew Lindstrom, Andrew Shiau
  • Publication number: 20050203151
    Abstract: Described herein are novel mono- and bicyclic compounds compounds, including compounds capable of modulating the activity of human peroxisome proliferator activated receptor of the subtype delta (hPPAR-delta), and methods for utilizing such modulation to treat a disease or condition mediated or impacted by hPPAR-delta activity such as Type 2 diabetes, syndrome X, dyslipidemia, and atherosclerotic diseases including vascular disease, coronary heart disease, cerebrovascular disease, and peripheral vessel disease. Also described are compounds that mediate and/or inhibit the activity of hPPAR-delta, and pharmaceutical compositions containing such compounds or pharmaceutically acceptable prodrugs, solvates, salts, esters, thioesters, or amides or pharmaceutically active metabolites thereof. Further described are methods for making and producing such compounds.
    Type: Application
    Filed: December 20, 2004
    Publication date: September 15, 2005
    Applicant: Kalypsys, Inc.
    Inventors: James Malecha, Cunxiang Zhao, Carmen Robinson, Sergio Duron, Michael Sertic, Stewart Noble
  • Publication number: 20050131050
    Abstract: A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders.
    Type: Application
    Filed: January 31, 2005
    Publication date: June 16, 2005
    Applicant: G.D. Searle & Co.
    Inventors: John Talley, Thomas Penning, Paul Collins, Donald Rogier, James Malecha, Julie Miyashiro, Stephen Bertenshaw, Ish Khanna, Matthew Graneto, Roland Rogers, Jeffery Carter, Stephen Docter, Stella Yu
  • Publication number: 20050032851
    Abstract: Prodrugs of COX-2 inhibitors are described as being useful in treating inflammation and inflammation-related disorders.
    Type: Application
    Filed: September 13, 2004
    Publication date: February 10, 2005
    Inventors: John Talley, James Malecha, Stephen Bertenshaw, Matthew Graneto, Jeffery Carter, Jinglin Li, Srinivasan Nagarajan, David Brown, Donald Rogier, Thomas Penning, Ish Khanna, Xiangdong Xu, Richard Weier
  • Publication number: 20050026907
    Abstract: Disclosed herein are carbonyl compounds of Formula I, II, or III, and others as described herein. Also disclosed are methods of treating disease, such as cancer, neurological disorders, including polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, autoimmune diseases and cardiovascular conditions, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
    Type: Application
    Filed: June 10, 2004
    Publication date: February 3, 2005
    Applicant: Kalypsys, Inc.
    Inventors: Paul Wash, Brandon Wiley, Christian Hassig, James Malecha, Stewart Noble
  • Publication number: 20050020505
    Abstract: The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the ?v?3 and/or the ?v?5 integrin without significantly inhibiting the ?v?6 integrin.
    Type: Application
    Filed: December 19, 2003
    Publication date: January 27, 2005
    Inventors: Thomas Rogers, Peter Ruminski, Srinivasan Nagarajan, Balekudru Devadas, James Malecha, Lawrence Miller, Joseph Rico, Hwang-Fun Lu, Laura Marrufo, Joe Collins
  • Patent number: 6265433
    Abstract: The present invention provides compounds having the structure: and pharmaceutically acceptable salts and stereoisomers thereof that are useful in the treatment of inflammatory diseases which are mediated by LTB4 production, such as psoriasis, ulcerative colitis, IBD, and asthma.
    Type: Grant
    Filed: May 14, 1999
    Date of Patent: July 24, 2001
    Assignee: G. D. Searle & Company
    Inventors: Barbara Baosheng Chen, Helen Chen, Mark Andrew Russell, Julie Marion Miyashiro, James Malecha, Thomas Dale Penning
  • Patent number: 6162823
    Abstract: The present invention provides compounds having the of the formula I: ##STR1## and pharmaceutically acceptable salts and stereoisomers thereof that are useful in the treatment of inflammatory diseases which are mediated by LTB.sub.4 production, such as psoriasis, ulcerative colitis, IBD, and asthma.
    Type: Grant
    Filed: March 12, 1997
    Date of Patent: December 19, 2000
    Assignee: G.D. Searle & Co.
    Inventors: Thomas Dale Penning, Stella Siu-tzyy Yu, James Malecha, Chi-Dean Liang, Mark Andrew Russell