Abstract: Knock down or other inhibition of C9ORF72 expression provides a method of treating cancer, in particular cancers susceptible to PARP inhibition such as glioblastoma. Thus, agents that target C9orf72, such as inhibitory oligonucleotides or antibodies can be used to treat cancers. A specific embodiment includes methods for treating cancers by administrating such agents, such as an inhibitory oligonucleotide that targets C9orf72. Also disclosed are methods that involve the co-administration of a PARP inhibitor and an agent that targets C9ORF72.

Abstract: Provided is a filter that filters air flowing from the filter to a downstream component, while preventing fluid from flowing from the filter to the downstream component and preventing a substance, such as urea or fuel, entering the filter from the downstream component from degrading the filter element in the filter. The filter includes a filter element having an interior surface defining an inner chamber and a standpipe extending through the inner chamber and terminating at a point that allows air that flows from outside the filter element through the filter element and into the inner chamber to flow into the standpipe and out of the filter, while preventing fluid flowing from the opposite direction through the standpipe from entering the filter element.

Abstract: The present invention is an ingestable blended formulation which will cause a series of distinct biochemical changes in-vivo; initiate desirable psychological consequences in that person; and induce an observable increase in cognitive functions for that living human subject. In particular, the initiated psychological events will generate a positive change in one's personal perceptions, evoke optimism as the subjective state of mind, and elicit a more sociable attitude and favorable mood as the observable behavior of the affected human person. Moreover, in addition to the initiation of a more positive state of mind, another major result and effect of ingesting the blended formulation is an observable amplification of human brain functions and a substantive increase of human concentration, focus and memory.

Abstract: Provided is a filter that filters air flowing from the filter to a downstream component, while preventing fluid from flowing from the filter to the downstream component and preventing a substance, such as urea or fuel, entering the filter from the downstream component from degrading the filter element in the filter. The filter includes a filter element having an interior surface defining an inner chamber and a standpipe extending through the inner chamber and terminating at a point that allows air that flows from outside the filter element through the filter element and into the inner chamber to flow into the standpipe and out of the filter, while preventing fluid flowing from the opposite direction through the standpipe from entering the filter element.

Abstract: The present invention is an ingestable blended formulation which will cause a series of distinct biochemical changes in-vivo; initiate desirable psychological consequences in that person; and induce an observable increase in cognitive functions for that living human subject. In particular, the initiated psychological events will generate a positive change in one's personal perceptions, evoke optimism as the subjective state of mind, and elicit a more sociable attitude and favorable mood as the observable behavior of the affected human person. Moreover, in addition to the initiation of a more positive state of mind, another major result and effect of ingesting the blended formulation is an observable amplification of human brain functions and a substantive increase of human concentration, focus and memory.

Abstract: The present invention is an ingestable blended formulation which will cause a series of distinct biochemical changes in-vivo; initiate desirable psychological consequences in that person; and induce an observable increase in cognitive functions for that living human subject. In particular, the initiated psychological events will generate a positive change in one's personal perceptions, evoke optimism as the subjective state of mind, and elicit a more sociable attitude and favorable mood as the observable behavior of the affected human person. Moreover, in addition to the initiation of a more positive state of mind, another major result and effect of ingesting the blended formulation is an observable amplification of human brain functions and a substantive increase of human concentration, focus and memory.

Abstract: The present invention comprises a purposefully formulated weight loss composition and a method for causing a meaningful weight loss in a living human subject. The formulated weight loss composition, in its most preferred embodiments comprises: at least one amino acid that is a pharmacologically active precursor in the catecholamine biosynthesis pathway; one or more sympathomimetic agents; a lipolytic agent; a high-Dalton macromolecular protein, and a plurality of micronutrients. The preferred composition is formulated as a dry particulate admixture initially; and then is made into a fluid beverage, which is able to achieve multiple physiologic functions in-vivo. These in-vivo functions include: causing a meaningful weight loss, with a preference for lipolysis and fat metabolism; providing for a low glycemic index; offering lean muscle maintenance and replenishment; and concomitantly initiating dopaminergic (D2-receptor) brain stimulation, resulting in improved cognitive function and affective augmentation.

Abstract: The present invention comprises a purposefully formulated weight loss composition and a method for causing a meaningful weight loss in a living human subject. The formulated weight loss composition, in its most preferred embodiments comprises: at least one amino acid that is a pharmacologically active precursor in the catecholamine biosynthesis pathway; one or more sympathomimetic agents; a lipolytic agent; a high-Dalton macromolecular protein, and a plurality of micronutrients. The preferred composition is formulated as a dry particulate admixture initially; and then is made into a fluid beverage, which is able to achieve multiple physiologic functions in-vivo. These in-vivo functions include: causing a meaningful weight loss, with a preference for lipolysis and fat metabolism; providing for a low glycemic index; offering lean muscle maintenance and replenishment; and concomitantly initiating dopaminergic (D2-receptor) brain stimulation, resulting in improved cognitive function and affective augmentation.

Abstract: A multi compartment container where a lid assembly has a lower part thereof setting down within the compartment defining base yet itself providing multiple compartments each closable by a lid.