Patents by Inventor James Masters

James Masters has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220091101
    Abstract: An oral biology model which comprises biofilm, oral epithelial tissue and a suspension of neutrophil-like cells in media is disclosed. The biofilm, which comprises oral bacteria, is produced by culturing oral bacteria on a solid substrate. The oral epithelial tissue may be gingival epithelial tissue to model the gingival crevice or buccal epithelial tissue to model the oral check. The suspension of neutrophil-like cells in media comprises neutrophil-like cells that are differentiated HL60 cells induced to a neutrophil-like phenotype by treatment with retinoic acid. Methods of using the oral biology model to test and compare compounds and formulations or to screen compounds and formulations for their effect on release of inflammatory signals, their effect on biofilm and oral bacteria and/or their effect on the cellular components are disclosed.
    Type: Application
    Filed: December 17, 2019
    Publication date: March 24, 2022
    Applicant: Colgate-Palmolive Company
    Inventors: Camille ZENOBIA, Harsh TRIVEDI, Ying YANG, Carlo DAEP, James MASTERS
  • Publication number: 20220071877
    Abstract: Methods of shifting biofilm composition in an individuals oral cavity are disclosed. The methods comprise applying to the individuals oral cavity an oral care composition in an amount effective to shift biofilm composition to increase the amount from healthy bacteria in biofilm relative to pathogenic bacteria in biofilm. The oral care composition comprising: zinc oxide, zinc citrate, and arginine. The shift in biofilm composition provides a balance having a greater amount of healthy bacteria in biofilm compared to pathogenic bacteria.
    Type: Application
    Filed: December 17, 2019
    Publication date: March 10, 2022
    Applicant: Colgate-Palmolive Company
    Inventors: Camille Zenobia, Carlo DAEP, Dandan CHEN, Harsh Mahendra TRIVEDI, James MASTERS
  • Publication number: 20220071868
    Abstract: Methods of increasing proteins that reduce signals associated with neutrophil recruitment and reducing proteins that induce neutrophil recruitment within an individuals gingival crevice are disclosed. The methods comprise applying to the individual's oral cavity in an amount effective to increase proteins that reduce signals associated with neutrophil recruitment and reduce proteins that induce neutrophil recruitment within an individuals gingival crevice, an oral care composition comprising: zinc oxide, zinc citrate, stannous fluoride, and optionally arginine and/or zingerone.
    Type: Application
    Filed: December 17, 2019
    Publication date: March 10, 2022
    Applicant: Colgate-Palmolive Company
    Inventors: Camille ZENOBIA, Carlo DAEP, Dandan CHEN, Harsh Mahendra TRIVEDI, James MASTERS
  • Publication number: 20220071867
    Abstract: Methods of increasing proteins that reduce signals associated with neutrophil recruitment and reducing proteins that induce neutrophil recruitment within an individuals gingival crevice are disclosed. The methods comprise applying to the individuals oral cavity in an amount effective to increase proteins that reduce signals associated with neutrophil recruitment and reduce proteins that induce neutrophil recruitment within an individuals gingival crevice, an oral care composition comprising: zinc phosphate, stannous fluoride and optionally, an organic acid buffer system.
    Type: Application
    Filed: December 17, 2019
    Publication date: March 10, 2022
    Applicant: Colgate-Palmolive Company
    Inventors: Camille ZENOBIA, Carlo DAEP, Dandan CHEN, Harsh Mahendra TRIVEDI, James MASTERS
  • Publication number: 20210404005
    Abstract: Described herein are methods used for the detection of gingivitis and the monitoring of gingivitis in a subject.
    Type: Application
    Filed: September 10, 2021
    Publication date: December 30, 2021
    Applicants: Colgate-Palmolive Company, The Regents of the University of California
    Inventors: David T.W. WONG, Karolina Elzbieta KACZOR-URBANOWICZ, Harsh Mahendra TRIVEDI, James MASTERS
  • Publication number: 20210404006
    Abstract: Described herein are methods used for the detection of gingivitis and the monitoring of gingivitis in a subject.
    Type: Application
    Filed: September 10, 2021
    Publication date: December 30, 2021
    Applicants: Colgate-Palmolive Company, The Regents of the University of California
    Inventors: David T.W. WONG, Karolina Elzbieta KACZOR-URBANOWICZ, Harsh Mahendra TRIVEDI, James MASTERS
  • Patent number: 11197811
    Abstract: Described herein are methods of cleaning a tooth comprising administering a composition comprising a zinc amino acid halide complex to the oral cavity; and retaining the composition in the oral cavity for a time sufficient to form a precipitate.
    Type: Grant
    Filed: February 24, 2020
    Date of Patent: December 14, 2021
    Assignee: Colgate-Palmolive Company
    Inventors: Zhiqiang Liu, Long Pan, Shaotang Yuan, Jairajh Mattai, James Masters
  • Publication number: 20210318306
    Abstract: Methods for identifying a composition that neutralizes toxicity of a lipopolysaccharide are disclosed. The methods comprise comparing the amount of cytokine and/or prostaglandin E2 secreted by cells that have Toll-like receptors activated by a lipopolysaccharide in the presence or absence of a test composition. Methods of neutralizing toxicity of a lipopolysaccharide in an individual's oral cavity using compositions identified neutralizing toxicity of a lipopolysaccharide are also disclosed. Method of neutralizing toxicity of a lipopolysaccharide in an individual's oral cavity using oral care compositions that comprise combinations of zinc oxide and zinc citrate are also disclosed.
    Type: Application
    Filed: April 2, 2021
    Publication date: October 14, 2021
    Applicant: Colgate-Palmolive Company
    Inventors: Dandan Chen, Harsh Mahendra Trivedi, James Masters
  • Publication number: 20210308028
    Abstract: Method of improving tissue integrity of tissue that functions as a barrier are provided. Method of protecting and maintaining tissue integrity of tissue that functions as a barrier are provided. Method of repairing damage to tissue that functions as a barrier, and to restoring and improving function of such damaged tissue are provided. Methods of improving, maintaining, protecting, repairing and/or restoring the integrity of tissue which functions as a barrier and repair of damage to and healing of wounds to such tissue improves, maintains, protects, repairs and restores immunity. The methods comprising contacting the tissue with an effective amount of a composition comprising one or more sources of zinc ions such as zinc oxide, zinc citrate, or combination thereof zinc oxide and zinc citrate, and optionally further comprising arginine and/or one or more neutral amino acids.
    Type: Application
    Filed: March 30, 2021
    Publication date: October 7, 2021
    Applicant: Colgate-Palmolive Company
    Inventors: Ying Yang, James Masters, Harsh Mahendra Trivedi, Tulika Sarma
  • Patent number: 11124833
    Abstract: Described herein are methods used for the detection of gingivitis and the monitoring of gingivitis in a subject.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: September 21, 2021
    Assignee: Colgate-Palmolive Company
    Inventors: David T. W. Wong, Karolina Elzbieta Kaczor-Urbanowicz, Harsh Mahendra Trivedi, James Masters
  • Patent number: 11116708
    Abstract: Personal care compositions including a naringin:zinc complex and methods for preparing and using the same are provided. The personal care compositions may include a carrier and a naringin:zinc complex having a 2:1 naringin to zinc molar ratio.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: September 14, 2021
    Assignee: Colgate-Palmolive Company
    Inventors: Shujiang Cheng, Zeenat Nabi, Laurence Du-Thumm, Qiang Wu, Jane Ong, Halyna Siomyk, Harsh Mahendra Trivedi, James Masters, Chi-Yuan Cheng, Donghui Wu
  • Patent number: 10773105
    Abstract: This invention relates to oral care compositions comprising zingerone, bisabolol, a stannous ion source, zinc oxide, and zinc citrate, as well as to methods of using and of making these compositions.
    Type: Grant
    Filed: May 29, 2019
    Date of Patent: September 15, 2020
    Assignee: Colgate-Palmolive Company
    Inventors: Ying Yang, Dandan Chen, Robert D'Ambrogio, Paul Thomson, Harsh Mahendra Trivedi, Michael Prencipe, James Masters, Stanislav Jaracz
  • Publication number: 20200246242
    Abstract: Personal care compositions including a naringin:zinc complex and methods for preparing and using the same are provided. The personal care compositions may include a carrier and a naringin:zinc complex having a 2:1 naringin to zinc molar ratio.
    Type: Application
    Filed: December 19, 2017
    Publication date: August 6, 2020
    Applicant: Colgate-Palmolive Company
    Inventors: Shujiang CHENG, Zeenat NABI, Laurence DU-THUMM, Qiang WU, Jane ONG, Halyna SIOMYK, Harsh Mahendra TRIVEDI, James MASTERS, Chi-Yuan CHENG, Donghui WU
  • Publication number: 20200236945
    Abstract: Antimicrobial compositions and methods for depositing or coating the antimicrobial or antibacterial compositions on a substrate to prevent microbial adhesion are provided. The antimicrobial composition may include a cationic polymer having a poly-allylamine backbone. A portion of the poly-allylamine backbone may be functionalized with at least one of a guanidine functional group and a biguanide functional group.
    Type: Application
    Filed: April 13, 2020
    Publication date: July 30, 2020
    Applicants: Colgate-Palmolive Company, The Trustees of the University of Pennsylvania
    Inventors: Carl MYERS, Carlo DAEP, Lynette ZAIDEL, James MASTERS, Russell COMPOSTO, Hyun-Su LEE
  • Publication number: 20200229909
    Abstract: In some embodiments, an oral care device includes a flexible base substrate, a power source disposed on the base substrate, and a flexible light source disposed on the base structure or on the power source. The flexible light source is in electrical communication with the power source. Also disclosed are methods of using the same, for example, for whitening the teeth or for treating other conditions in the oral cavity.
    Type: Application
    Filed: April 2, 2020
    Publication date: July 23, 2020
    Applicant: Colgate-Palmolive Company
    Inventors: Patrik JOHANSSON, John GATZEMEYER, Harsh Mahendra TRIVEDI, James MASTERS
  • Publication number: 20200206106
    Abstract: Methods of increasing sIgA and mucin 5B levels in an individual's oral cavity are disclosed. The methods comprise applying to the individual's oral cavity in an amount effective to increase sIgA and mucin 5B levels in the individual's oral cavity, an oral care composition comprising: zinc phosphate, stannous fluoride and optionally, an organic acid buffer system.
    Type: Application
    Filed: December 17, 2019
    Publication date: July 2, 2020
    Applicant: Colgate-Palmolive Company
    Inventors: Dandan CHEN, Harsh Mahendra TRIVEDI, Ying YANG, James MASTERS
  • Publication number: 20200206115
    Abstract: Described herein are methods of cleaning a tooth comprising administering a composition comprising a zinc amino acid halide complex to the oral cavity; and retaining the composition in the oral cavity for a time sufficient to form a precipitate.
    Type: Application
    Filed: February 24, 2020
    Publication date: July 2, 2020
    Applicant: Colgate-Palmolive Company
    Inventors: Zhiqiang LIU, Long PAN, Shaotang YUAN, Jairajh MATTAI, James MASTERS
  • Patent number: 10653149
    Abstract: Antimicrobial compositions and methods for depositing or coating the antimicrobial or antibacterial compositions on a substrate to prevent microbial adhesion are provided. The antimicrobial composition may include a cationic polymer having a poly-allylamine backbone. A portion of the poly-allylamine backbone may be functionalized with at least one of a guanidine functional group and a biguanide functional group.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: May 19, 2020
    Assignee: Colgate-Palmolive Company
    Inventors: Carl Myers, Carlo Daep, Lynette Zaidel, James Masters, Russell Composto, Hyun-Su Lee
  • Patent number: 10610475
    Abstract: Described herein are methods of cleaning a tooth comprising administering a composition comprising a zinc amino acid halide complex to the oral cavity; and retaining the composition in the oral cavity for a time sufficient to form a precipitate.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: April 7, 2020
    Assignee: Colgate-Palmolive Company
    Inventors: Zhiqiang Liu, Long Pan, Shaotang Yuan, Jairajh Mattai, James Masters
  • Patent number: 10610470
    Abstract: The invention provides a zinc-lysine complex having the formula [Zn(C6H14N2O2)2Cl]+Cl? having antibacterial and antiperspirant properties, together with personal care compositions comprising the complex, and methods of making and using these complexes and compositions.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: April 7, 2020
    Assignee: Colgate-Palmolive Company
    Inventors: Long Pan, Jairajh Mattai, Shaotang Yuan, James Masters