Abstract: A dispenser actuator assembly (100) for actuating a dispenser (10) is disclosed. The dispenser (10) is in the form of a glass ampoule assembly (10) having a rupturable glass ampoule (12) containing a flowable material (M). The glass ampoule (12) is contained within an outer container (14) wherein the outer container (14) has a distal end segment defining a first open end (22) and a second closed end (24). The dispenser actuator assembly (100) has a base member (102) having an opening (110) configured to mount to the outer container (14). The base member (102) has an outlet aperture (280) configured to be in fluid communication with the outer container (14). The base member (102) has an applicator (250) integrally formed thereon and extending from the base member (102). The applicator is in fluid communication with the outlet aperture (280).

Abstract: A patient interface for delivery of a supply of pressurised air or breathable gas to an entrance of a patient's airways comprising: a cushion member that includes a retaining structure and a seal-forming structure permanently connected to the retaining structure; a frame member attachable to the retaining structure; and a positioning and stabilising structure attachable to the frame member.

Abstract: Disclosed are compositions and methods for inactivating one or more enzymes in a biological sample.

Abstract: A door system for an appliance includes a panel and a door having an inner surface. A bracket is coupled to the door. A rail assembly is disposed on an opposing side of the panel relative to the door. The bracket engages the rail assembly through the panel to adjust the door between an opened position and a closed position via the rail assembly. The door is configured to a deployed position.

Abstract: The compounds of the invention are modulators of the Factor XII (e.g. Factor XIIa). In particular, the compounds are inhibitors of Factor XIIa and may be useful as anticoagulants.

Abstract: A patient interface for delivery of a supply of pressurised air or breathable gas to an entrance of a patient's airways comprising: a cushion member that includes a retaining structure and a seal-forming structure permanently connected to the retaining structure; a frame member attachable to the retaining structure; and a positioning and stabilising structure attachable to the frame member.

Abstract: A device for treating a tissue opening includes a proximal portion including an elongated flexible member, a capsule releasably coupled to a distal end of the flexible member and including a lumen extending therethrough and a clip including a pair of arms movably housed within the capsule. A suture extending along a first one of the pair of arms and including a loop at a distal end thereof extending across an opening extending through the first one of the pair of arms. A suture grabbing element extending laterally from a second one of the pair of arms and including a hook so that, when the pair of arms are moved toward a closed configuration, the hook extends through the opening to grab the loop and draw the distal end of the suture from the first one of the pair of arms toward the second one of the pair of arms.

Abstract: The Tool to Control Sexual Devices is an apparatus comprising: 1) an at least one handle, which is a solid mass of suitable size and shape which provides an easy and comfortable means for a user to move and position an at least one nucleus and thereby move and position an at least one sexual device, comprising a vibrator, a dildo, a dong, or a plug, with at least one Legs, in a manner which can provide gratifying sexual stimulation, and 2) an at least one nucleus, which is a solid mass of suitable size and shape and functions as a means to transmit motion from the at least one handle to the at least one sexual device, and 3) an at least one fulcrum, which is a solid mass of suitable size and shape and functions as support for the nucleus on which the nucleus can pivot.

Abstract: In at least one embodiment, an active noise cancellation (ANC) system is provided. The ANC system includes at least one loudspeaker, at least one microphone and at least one controller. The at least one loudspeaker projects anti-noise sound within a cabin of a vehicle based at least on an anti-noise signal. The at least one microphone provides an error signal indicative of noise and the anti-noise sound within the cabin. The at least one controller is programmed to receive the error signal and a reference signal indicative of a gear shift that occurs over a predetermined time interval and to adapt at least one adaptive filter with pre-stored filter coefficients for the predetermined time interval to generate the anti-noise signal based at least on the error signal and the reference signal.

Abstract: A biometrically locked medication bottle lid including a bottle assembly, an alarm assembly and a lock assembly is disclosed herein. The bottle assembly includes a lid and a dispenser mechanism comprising a spring and a tray to dispense medicament. The alarm assembly includes a digital display that is attached to the front side of the bottle. A speaker and a light are also attached to the front side of the bottle and can be activated when an alarm is triggered indicating that it is time for a user to take their medication. The lock assembly includes a fingerprint sensor and a lock mechanism. The lock mechanism is actuated when the fingerprint sensor scans the fingerprint of the user.

Abstract: Various embodiments of the present technology provide compositions and methods for a sweetener composition comprising stevia leaf extract, stevia glycosides, and/or Luo Han Guo fruit extract. The sweetener composition provides enhanced taste and/or flavor properties as compared to other non-caloric or low-caloric sweeteners. The sweetener composition has a reduced aftertaste relative to stevia leaf extract and/or purified steviol glycoside. The sweetener composition may be formulated into any edible sweetened substances.

Abstract: A dispenser actuator assembly (100) for actuating a dispenser (10) is disclosed. The dispenser (10) is in the form of a glass ampoule assembly (10) having a rupturable glass ampoule (12) containing a flowable material (M). The glass ampoule (12) is contained within an outer container (14) wherein the outer container (14) has a first open end (22) and a second closed end (24). The glass ampoule assembly (10) has an applicator (16) positioned in the first open end (22). The dispenser actuator assembly (100) has a base member (102) configured to mount on the outer container (14). The dispenser actuator assembly (100) also has an actuator assembly (104) operably connected to the base member (102) wherein the actuator assembly (104) has a first actuator arm (132a) and a second actuator arm (132b) each pivotally connected to the base member (102).

Abstract: A dispenser actuator assembly (100) for actuating a dispenser (10) has a base member (102) operably connected to an actuator assembly (104). The dispenser (10) is in the form of a glass ampoule assembly (10) having a rupturable glass ampoule (12) containing a flowable material (M). The glass ampoule (12) is contained within an outer container (14). The glass ampoule assembly (10) has an applicator (16) positioned in the outer container (14). The dispenser actuator assembly (100) has the base member (102) that is configured to mount on the outer container (14). The actuator assembly (104) has a first actuator arm (132a) and a second actuator arm (132b) each pivotally connected to the base member (102). The first actuator arm (132a) has a first protrusion (150a) depending therefrom and the second actuator arm (132b) has a second protrusion (150b) depending therefrom.

Abstract: Various embodiments of the present technology provide compositions and methods for a sweetener composition comprising stevia leaf extract, stevia glycosides, and/or Luo Han Guo fruit extract. The sweetener composition provides enhanced taste and/or flavor properties as compared to other non-caloric or low-caloric sweeteners. The sweetener composition has a reduced aftertaste relative to stevia leaf extract and/or purified steviol glycoside. The sweetener composition may be formulated into any edible sweetened substances.

Abstract: An implantable fixation device for rejoining opposed portions of a separated bone. The device including two corresponding plates that are configured to be aligned and coupled to a bone, such as a sternum, pre-resection of the bone or prior to cutting/separating the bone. The placement of the corresponding plates provides a gap between the edges of the plates that face one another allowing for and guiding a cutting tool for separating the bone. After the bone has been cut and the desired surgical procedure performed, the plates also assist in realigning and fixation of the bone portions. At least one plate includes a ratchet mechanism that is configured to tighten a locking element and draw the two plates together and into alignment with one another.

Abstract: A dispenser actuator assembly (100) for actuating a dispenser (10) is disclosed. The dispenser (10) is in the form of a glass ampoule assembly (10) having a rupturable glass ampoule (12) containing a flowable material (M). The glass ampoule (12) is contained within an outer container (14) wherein the outer container (14) has a first open end (22) and a second closed end (24). The glass ampoule assembly (10) has an applicator (16) positioned in the first open end (22). The dispenser actuator assembly (100) has a base member (102) configured to mount on the outer container (14). The dispenser actuator assembly (100) also has an actuator assembly (104) operably connected to the base member (102) wherein the actuator assembly (104) has a first actuator arm (132a) and a second actuator arm (132b) each pivotally connected to the base member (102).

Abstract: A dispenser (10) for dispensing a flowable material M has a container (12) having an outer wall (20) and membrane (14) collectively defining a first chamber (22) configured to contain the flowable material M. The membrane (14) has a thickness and a weld seam (40) wherein the weld seam (40) has a thickness less than the thickness of the membrane (14). A fracturing mechanism (16) is operably connected to the container (12). The fracturing mechanism (16) has an extending member (64) projecting from the outer wall (20) of the container (12). The extending member (64) has a projection (66) positioned proximate the membrane (14), wherein in response to deflection of the extending member (64), the projection (66) deflects the outer wall (20) proximate the membrane (14) wherein the weld seam (40) fractures creating an opening (41) through the membrane (14) configured to allow the flowable material M to pass therethrough and from the dispenser (10).

Abstract: Various embodiments of the present technology provide a sweetener composition comprising stevia glycosides that may be stably soluble in an aqueous solution, and methods for their manufacture. In various embodiments, the sweetener composition may comprise at least one stevia glycoside and a natural emulsifier. The natural emulsifier of the sweetener composition may enhance the aqueous solubility of the stevia glycoside to increase the concentration of dissolved stevia glycoside relative to its inherent aqueous solubility. The sweetener composition may be stably soluble upon formulation into any edible sweetened substances.

Abstract: The invention is a vapourising device (10) for vapourising a volatile liquid for supply to an environment. The device has a housing 100 having an inlet (109) for receiving inlet air which is warmed by inlet heater (111) before being supplied to cartridge assembly (200). Cartridge assembly (200) has a reservoir (204) for containing the liquid to be vapourised and at least one wick (206), one end of which is located in the reservoir to receive and transport the liquid to the other, exposed end of the wick where the liquid evaporates and mixes with the supplied stream of heated inlet air. The wick may be heated by a wick heater (211). The device also includes an outlet duct section (217) between the wick (206) and the outlet (221) which is conical in shape and is configured to accelerate the flow of the mixture of inlet air and vapourised liquid away from the wick towards the outlet (221).