Patents by Inventor James Mayhew

James Mayhew has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230107032
    Abstract: This invention relates to benzodiazepine derivatives, compositions comprising therapeutically effective amounts of those derivatives and methods of using those derivatives or compositions in treating cognitive impairment associated with CNS disorders. It also relates to the use of an ?5-containing GABAA receptor agonist (e.g., an ?5-containing GABAA receptor positive allosteric modulator) in treating cognitive impairment associated with CNS disorders in a subject in need or at risk thereof, including age-related cognitive impairment, Mild Cognitive Impairment (MCI), amnestic MCI, Age-Associated Memory Impairment, Age Related Cognitive Decline, dementia, Alzheimer's Disease (AD), prodromal AD, PTSD, schizophrenia, bipolar disorder, ALS, cancer-therapy-related cognitive impairment, mental retardation, Parkinson's disease, autism spectrum disorders, fragile X disorder, Rett syndrome, compulsive behavior, and substance addiction. It also relates to the use of an ?5-containing GABAA receptor agonist (e.g.
    Type: Application
    Filed: June 27, 2022
    Publication date: April 6, 2023
    Inventors: Belew Mekonnen, John A. Butera, Jianxing Huang, Hemantbhai Patel, Qin Jiang, Robert Jason Herr, Emily Elizabeth Freeman, Nicholas James Mayhew
  • Publication number: 20230098667
    Abstract: This invention relates to benzodiazepine derivatives, compositions comprising therapeutically effective amounts of those derivatives and methods of using those derivatives or compositions in treating cognitive impairment associated with CNS disorders. It also relates to the use of an ?5-containing GABAA receptor agonist (e.g, an ?5-containing GABAA receptor positive allosteric modulator) in treating cognitive impairment associated with CNS disorders in a subject in need or at risk thereof, including age-related cognitive impairment, Mild Cognitive Impairment (MCI), amnestic MCI, Age-Associated Memory Impairment, Age Related Cognitive Decline, dementia, Alzheimer's Disease (AD), prodromal AD, PTSD, schizophrenia, bipolar disorder, ALS, cancer-therapy-related cognitive impairment, mental retardation, Parkinson's disease, autism spectrum disorders, fragile X disorder, Rett syndrome, compulsive behavior, and substance addiction. It also relates to the use of an ?5-containing GABAA receptor agonist (e.g.
    Type: Application
    Filed: December 18, 2020
    Publication date: March 30, 2023
    Inventors: Belew Mekonnen, John A. Butera, Jianxing Huang, Hemantbhai Patel, Qin Jiang, Robert Jason Herr, Emily Elizabeth Freeman, Nicholas James Mayhew
  • Patent number: 11414425
    Abstract: This invention relates to benzodiazepine derivatives, compositions comprising therapeutically effective amounts of those derivatives and methods of using those derivatives or compositions in treating cognitive impairment associated with CNS disorders. It also relates to the use of an ?5-containing GABAA receptor agonist (e.g., an ?5-containing GABAA receptor positive allosteric modulator) in treating cognitive impairment associated with CNS disorders in a subject in need or at risk thereof, including age-related cognitive impairment, Mild Cognitive Impairment (MCI), amnestic MCI, Age-Associated Memory Impairment, Age Related Cognitive Decline, dementia, Alzheimer's Disease (AD), prodromal AD, PTSD, schizophrenia, bipolar disorder, ALS, cancer-therapy-related cognitive impairment, mental retardation, Parkinson's disease, autism spectrum disorders, fragile X disorder, Rett syndrome, compulsive behavior, and substance addiction. It also relates to the use of an ?5-containing GABAA receptor agonist (e.g.
    Type: Grant
    Filed: June 19, 2019
    Date of Patent: August 16, 2022
    Assignee: AGENEBIO, INC.
    Inventors: Belew Mekonnen, John A. Butera, Jianxing Huang, Hemantbhai Patel, Qin Jiang, Robert Jason Herr, Emily Elizabeth Freeman, Nicholas James Mayhew
  • Publication number: 20200048268
    Abstract: This invention relates to benzodiazepine derivatives, compositions comprising therapeutically effective amounts of those derivatives and methods of using those derivatives or compositions in treating cognitive impairment associated with CNS disorders. It also relates to the use of an ?5-containing GABAA receptor agonist (e.g., an ?5-containing GABAA receptor positive allosteric modulator) in treating cognitive impairment associated with CNS disorders in a subject in need or at risk thereof, including age-related cognitive impairment, Mild Cognitive Impairment (MCI), amnestic MCI, Age-Associated Memory Impairment, Age Related Cognitive Decline, dementia, Alzheimer's Disease (AD), prodromal AD, PTSD, schizophrenia, bipolar disorder, ALS, cancer-therapy-related cognitive impairment, mental retardation, Parkinson's disease, autism spectrum disorders, fragile X disorder, Rett syndrome, compulsive behavior, and substance addiction. It also relates to the use of an ?5-containing GABAA receptor agonist (e.g.
    Type: Application
    Filed: June 19, 2019
    Publication date: February 13, 2020
    Inventors: Belew Mekonnen, John A. Butera, Jianxing Huang, Hemantbhai Patel, Qin Jiang, Robert Jason Herr, Emily Elizabeth Freeman, Nicholas James Mayhew
  • Patent number: 10251401
    Abstract: The present invention is directed to non-aqueous, non-oil liquid compositions comprising Bacillus amyloliquefaciens and a liquid carrier. The present invention is further directed methods of controlling nematodes comprising applying an effective amount of a non-aqueous, non-oil liquid composition comprising Bacillus amyloliquefaciens and a liquid carrier to an area in need of nematode control.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: April 9, 2019
    Assignee: VALENT BIOSCIENCES LLC
    Inventors: Zhengyu Huang, Benjamin A. Belkind, Venkat Gangavarapu, Zuoxing Zheng, Todd James Mayhew, Ana Vida C. Alcala
  • Publication number: 20190021335
    Abstract: The present invention is directed to non-aqueous, non-oil liquid compositions comprising Bacillus amyloliquefaciens and a liquid carrier. The present invention is further directed methods of controlling nematodes comprising applying an effective amount of a non-aqueous, non-oil liquid composition comprising Bacillus amyloliquefaciens and a liquid carrier to an area in need of nematode control.
    Type: Application
    Filed: September 26, 2018
    Publication date: January 24, 2019
    Inventors: Zhengyu Huang, Benjamin A. Belkind, Venkat Gangavarapu, Zuoxing Zheng, Todd James Mayhew, Ana Vida C. Alcala
  • Patent number: 10111439
    Abstract: The present invention is directed to non-aqueous, non-oil liquid compositions comprising Bacillus amyloliquefaciens and a liquid carrier. The present invention is further directed methods of controlling nematodes comprising applying an effective amount of a non-aqueous, non-oil liquid composition comprising Bacillus amyloliquefaciens and a liquid carrier to an area in need of nematode control.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: October 30, 2018
    Assignee: VALENT BIOSCIENCES LLC
    Inventors: Zhengyu Huang, Benjamin A. Belkind, Venkat Gangavarapu, Zuoxing Zheng, Todd James Mayhew, Ana Vida C. Alcala
  • Publication number: 20170347663
    Abstract: The present invention is directed to non-aqueous, non-oil liquid compositions comprising Bacillus amyloliquefaciens and a liquid carrier. The present invention is further directed methods of controlling nematodes comprising applying an effective amount of a non-aqueous, non-oil liquid composition comprising Bacillus amyloliquefaciens and a liquid carrier to an area in need of nematode control.
    Type: Application
    Filed: June 2, 2017
    Publication date: December 7, 2017
    Inventors: Zhengyu Huang, Benjamin A. Belkind, Venkat Gangavarapu, Zuoxing Zheng, Todd James Mayhew, Ana Vida C. Alcala
  • Publication number: 20160128338
    Abstract: The invention relates to compositions and methods for improving the health, appearance, and quality of turf grasses by application of compositions containing metconazole and Myrothecium verucaria fermentation solids and solubles to areas of turf grass growth.
    Type: Application
    Filed: November 6, 2014
    Publication date: May 12, 2016
    Inventors: Todd James Mayhew, Jill Marie Calabro
  • Patent number: 7829523
    Abstract: Methionine is an effective antioxidant for polypeptides having an amino acid sequence lacking methionine. Compositions containing polypeptides having an amino acid sequence that is free of methionine residues are stabilized from oxidative degradation by combining methionine in the composition in an amount effective to inhibit oxidation of the polypeptide.
    Type: Grant
    Filed: February 13, 2008
    Date of Patent: November 9, 2010
    Assignee: Dow Pharmaceutical Sciences
    Inventors: James Mayhew, Hali Wagner
  • Publication number: 20080139454
    Abstract: Methionine is an effective antioxidant for polypeptides having an amino acid sequence lacking methionine. Compositions containing polypeptides having an amino acid sequence that is free of methionine residues are stabilized from oxidative degradation by combining methionine in the composition in an amount effective to inhibit oxidation of the polypeptide.
    Type: Application
    Filed: February 13, 2008
    Publication date: June 12, 2008
    Inventors: James Mayhew, Hali Wagner
  • Publication number: 20070191271
    Abstract: Methionine is an effective antioxidant for polypeptides having an amino acid sequence lacking methionine. Compositions containing polypeptides having an amino acid sequence that is free of methionine residues are stabilized from oxidative degradation by combining methionine in the composition in an amount effective to inhibit oxidation of the polypeptide.
    Type: Application
    Filed: February 10, 2006
    Publication date: August 16, 2007
    Inventors: James Mayhew, Hali Wagner