Abstract: An illumination device includes an elongated flexible body having a first end connected to a second end via a flexible connecting body and an illumination portion coupled to the first end and a coupling portion coupled to the second end, wherein the illumination portion includes one or more illuminating sources and a first magnetic component housed within the illumination portion, the coupling portion includes a second magnetic component housed within the coupling portion, and the flexible connecting body is capable of folding such that the illumination portion and the coupling portion axially align and the first magnetic component magnetically couples to the second magnetic component.

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating cystic fibrosis, e.g., in subjects having a mutation resulting in F508del, are described.

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating phenylketonuria (PKU) are described.

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating alpha-1 antitrypsin deficiency (AATD) are described.

Abstract: An illumination device includes one or more illumination sources each comprising a length of material and one or more lights configured to illuminated the length of the material, one or more mounting brackets configured to receive a portion of the length of the one or more illumination sources and couple the received portion of the one or more illumination sources to a surface of an object, a control module comprising a power source and an electrical circuit, wherein the electrical circuit is configured to electrically couple the power source to the one or more illumination sources based on operation of a switch in the electrical circuit, and a control module mounting bracket configured to selectively secure the control module to the surface of the object.

Abstract: An illuminated toss bag includes an outer shell configured to form a toss bag defining an internal portion for receiving and retaining filling material; one or more illuminating portions disposed within the internal portion; and a hidden enclosing feature disposed along a seam of outer shell of the toss bag selectively providing access to the internal portion of the toss bag, wherein the filling material comprises a semi-transparent pellet shaped material, the one or more illuminating portions comprise a housing enclosing a power source, one or more illumination sources, and at least one switch, and the at least one switch controls operation of the one or more illumination sources, when the at least one switch is depressed for at least one second.

Abstract: An illumination device includes an elongated flexible body having a first end connected to a second end via a flexible connecting body and an illumination portion coupled to the first end and a coupling portion coupled to the second end, wherein the illumination portion includes one or more illuminating sources and a first magnetic component housed within the illumination portion, the coupling portion includes a second magnetic component housed within the coupling portion, and the flexible connecting body is capable of folding such that the illumination portion and the coupling portion axially align and the first magnetic component magnetically couples to the second magnetic component.

Abstract: An illuminated paddle includes a frame comprising a paddle portion, a handle portion extending from the paddle portion, a perimeter that extends around the paddle portion and the handle portion, and a channel positioned along at least a portion of the perimeter, the paddle portion comprising a plurality of internal strength members that define a plurality of cavities, a light source assembly disposed at an end of the handle portion, the light source assembly comprising at least one light source, and a light pipe disposed within at least a portion of the channel of the frame, the light pipe is optically coupled to the at least one light source.

Abstract: A method and system for tracing components in computer applications is provided in which trace data from components can be logged in real time. A hierarchical control interface 209 is used in which leaf nodes 306-311 represent components 204 being traced. The hierarchical control interface 209 includes means for setting trace levels for components 204 being traced. A non-hierarchical trace system 210 is used for carrying out the trace processing and includes means 320 for storing trace level settings received from the hierarchical control interface 209. The trace system 210 also includes means 322 for receiving a call from a component 204 with trace data; means for checking the trace level settings 321 for the component 204; and means for storing or discarding the trace data accordingly.

Abstract: Provided are a method, apparatus, and computer program product for testing a virtualized storage system. Data defining one or more configuration features of the virtualized storage system is received. Also received is a set of one or more predetermined rules defining interpretation of the disk exercising commands, the interpretation being dependent on one or more of the configuration features. A first disk exercising command is received. The first disk exercising command is interpreted in accordance with one of the predetermined rules to produce a second disk exercising command. The second disk exercising command is sent to the virtualized storage system.

Abstract: A method and system for tracing components in computer applications is provided in which trace data from components can be logged in real time. A hierarchical control interface 209 is used in which leaf nodes 306-311 represent components 204 being traced. The hierarchical control interface 209 includes means for setting trace levels for components 204 being traced. A non-hierarchical trace system 210 is used for carrying out the trace processing and includes means 320 for storing trace level settings received from the hierarchical control interface 209. The trace system 210 also includes means 322 for receiving a call from a component 204 with trace data; means for checking the trace level settings 321 for the component 204; and means for storing or discarding the trace data accordingly.

Abstract: A method for tracing components in computer applications includes setting, within a hierarchical control interface, a trace level for a component; storing, within a non-hierarchical trace system, the trace level; receiving, in the non-hierarchical trace system, a call with trace data from the component; checking, within the non-hierarchical trace system, the trace level of the component; and acting upon the trace data according to the trace level setting.

Abstract: Provided are a method, apparatus, and computer program product for testing a virtualised storage system. Data defining one or more configuration features of the virtualised storage system is received. Also received is a set of one or more predetermined rules defining interpretation of the disk exercising commands, the interpretation being dependent on one or more of the configuration features. A first disk exercising command is received. The first disk exercising command is interpreted in accordance with one of the predetermined rules to produce a second disk exercising command. The second disk exercising command is sent to the virtualised storage system.

Abstract: A conjugated prodrug of an estradiol compound conjugated to a biological activity modifying agent.

Abstract: Non-polar tantalum capacitors and non-polar tantalum capacitor arrays with compact designs are provided. The reduced volume and footprint of the capacitors and arrays in turn reduces the amount of space required in any device in which they are used. In addition, the cost of materials is reduced, and the manufacturing is simplified. Some embodiments of the present invention provide an electromechanical connector between the anode rods of each pair of polar tantalum capacitors, and insulation between the remainder of the capacitor bodies, thus providing a non-polar tantalum capacitor. These non-polar capacitors are mechanically connected to make a non-polar tantalum capacitor array. Other embodiments of the present invention provide for physically connecting the anode rods of the polar capacitors. An insulating encapsulant around the connected rods and between the polar capacitor bodies also holds the capacitors and capacitor arrays together.

Abstract: Non-polar tantalum capacitors and non-polar tantalum capacitor arrays with compact designs are provided. The reduced volume and footprint of the capacitors and arrays in turn reduces the amount of space required in any device in which they are used. In addition, the cost of materials is reduced, and the manufacturing is simplified. Some embodiments of the present invention provide an electromechanical connector between the anode rods of each pair of polar tantalum capacitors, and insulation between the remainder of the capacitor bodies, thus providing a non-polar tantalum capacitor. These non-polar capacitors are mechanically connected to make a non-polar tantalum capacitor array. Other embodiments of the present invention provide for physically connecting the anode rods of the polar capacitors. An insulating encapsulant around the connected rods and between the polar capacitor bodies also holds the capacitors and capacitor arrays together.

Abstract: Apparatus for aligning and orienting generally elongate objects of irregular shape and variable dimensions such as wood residue. The apparatus includes a plurality of spaced, rollers to transport the objects in a direction of transport from an inlet zone through a sorting zone to an outlet zone by rotation of the rollers. There are a plurality of aligning walls extending over the rollers parallel to the direction of transport from the outlet zone toward the inlet zone. There are also eccentric vanes mounted to some of the rollers to rotate with the rollers to move through the objects on the rollers. Objects introduced into the inlet zone in a generally random, entangled collection are aligned and oriented in the direction of transport into generally, parallel, stacked relationship at the outlet zone by movement over the rollers between the aligning walls subject to the action of the eccentric vanes.

Abstract: Methods and apparatus for enabling simultaneous transmission of voice and data signals over a single subscriber line. Signals are time division multiplexed preferably using an ISDN access format such as the Basic Access or Primary Rate formats, but are treated separately at the exchange. Subscriber equipment combines signals from local computer and telephone devices for separation at corresponding exchange equipment. Similarly the exchange equipment combines signals from one or more packet networks and the public telephone network for separation at the subscriber equipment. Data signals are therefore passed by the exchange directly to or from a packet switched network while voice signals are passed directly to or from a telephone switched network. Channels available over the subscriber line are dynamically allocated with telephone signals generally taking preference over data signals.

Abstract: An analog to a gravitation force field is generated mathematically to operate between the displayed image of the mouse selection pointer on the screen of a computer display as it interacts with defined selectable objects on the screen. Unlike true gravity, however, the force may be mathematically defined as positive or negative and, thus, permits both attractive and repulsive effects to be imposed upon the movement of the mouse selection pointer displayed on the screen. The paradigm of interaction between the mouse selection pointer displayed on the screen and objects which are selectable thereon is changed to include effects of "mass" as represented by an effective field of force operating between the mouse selection pointer display and various selectable items on the screen.