Abstract: A personal watercraft cart assembly includes a cart which includes a lower shell and an upper shell hingedly coupled to the lower shell such that the cart defines a hollow body when the upper shell is in a closed position on the lower shell. A pair of rollers is rotatably coupled to the cart for rolling the cart along a support surface. A pair of cradles is coupled to the upper shell to support a personal watercraft for transport the personal watercraft. The cart is comprised of a buoyant material to float behind the personal watercraft. A pair of straps is coupled to the upper shell for securing the personal watercraft on the cart. A light emitter is coupled to the cart to emit light outwardly from the cart thereby enhancing visibility of the cart in a darkened environment.

Abstract: A personal watercraft cart assembly includes a cart which includes a lower shell and an upper shell hingedly coupled to the lower shell such that the cart defines a hollow body when the upper shell is in a closed position on the lower shell. A pair of rollers is rotatably coupled to the cart for rolling the cart along a support surface. A pair of cradles is coupled to the upper shell to support a personal watercraft for transport the personal watercraft. The cart is comprised of a buoyant material to float behind the personal watercraft. A pair of straps is coupled to the upper shell for securing the personal watercraft on the cart. A light emitter is coupled to the cart to emit light outwardly from the cart thereby enhancing visibility of the cart in a darkened environment.

Abstract: The present invention relates to novel anti-TB cyclic peptides from Nonomuraea sp. MJM5123, a process for the production of the anti-Tuberculosis peptide and a pharmaceutical composition for the prevention and treatment of mycobacterial infection comprising the same. The composition of the present invention is highly active against replicating/non-replicating M. tuberculosis, including MDR and XDR strains, so that it can be effectively used as a therapeutic agent for tuberculosis.

Abstract: The present invention relates to novel anti-TB cyclic peptides from Nonomuraea sp. MJM5123, a process for the production of the anti-Tuberculosis peptide and a pharmaceutical composition for the prevention and treatment of mycobacterial infection comprising the same. The composition of the present invention is highly active against replicating/non-replicating M. tuberculosis, including MDR and XDR strains, so that it can be effectively used as a therapeutic agent for tuberculosis.

Abstract: A system and method for validating data for a machine arrangement includes a controller, such as a programmable logic controller, connected to a processor, which is configured to execute an algorithm using the data collected by the controller. The algorithm includes one or more rules that are applicable to the collected data. Each rule is applied to the data to determine if any of the data entries violate one or more of the rules. An output is generated indicating whether the data violates any of the rules, thereby providing information regarding the validity of the data being captured.

Abstract: The present invention relates to crystalline forms of ECO-4601 and the processes for providing them. The invention further relates to pharmaceutical compositions comprising the crystalline forms and to methods of use of the crystalline forms as pharmaceuticals.

Abstract: Textual fault messages in PLC-based manufacturing systems are supplemented by automatically displayed sets of information that allow an operator to quickly identify, recognize and visualize components responsible for producing faults. Visual display of stored computer generated images showing system components and tooling allow the operator to visually pinpoint the exact component responsible for the fault, and its location within the manufacturing system. Stored information associated with the component producing the fault, such as installation date, vendor sources, replacement part inventory, programming logic and editing software, is also automatically recalled and displayed along with the fault message to aid fault diagnosis and correction.

Abstract: A system and method for validating data for a machine arrangement includes a controller, such as a programmable logic controller, connected to a processor, which is configured to execute an algorithm using the data collected by the controller. The algorithm includes one or more rules that are applicable to the collected data. Each rule is applied to the data to determine if any of the data entries violate one or more of the rules. An output is generated indicating whether the data violates any of the rules, thereby providing information regarding the validity of the data being captured.

Abstract: The invention relates to a method and system for identifying a secondary metabolite synthesized by a target gene cluster within a microorganism. A putative or confirmed function is attributed to a gene within the gene cluster, and an extract from the microorganism is obtained which is suspected to contain the secondary metabolite synthesized by the gene cluster. The extract is then assessed for chemical, physical or biological properties, and the metabolite is identified and optionally isolated. Further, the invention provides a knowledge repository in which gene cluster information is linked to secondary metabolite production data. The invention further relates to a graphical user interface for accessing the knowledge repository, and a memory for storing data, having a data structure that is stored in the memory.

Abstract: Textual fault messages in PLC-based manufacturing systems are supplemented by automatically displayed sets of information that allow an operator to quickly identify, recognize and visualize components responsible for producing faults. Visual display of stored computer generated images showing system components and tooling allow the operator to visually pinpoint the exact component responsible for the fault, and its location within the manufacturing system. Stored information associated with the component producing the fault, such as installation date, vendor sources, replacement part inventory, programming logic and editing software, is also automatically recalled and displayed along with the fault message to aid fault diagnosis and correction.

Abstract: A waste trap 10 for use in plumbing installations is provided, the trap comprising a unitary metal body 12 defining an interior volume, and having a tubular plastics insert 20 located in an inlet 14 of the body 12 and extending into the volume to below the height of a waste outlet 16. The insert 20 partitions the upper portion of the volume into two regions, and serves to provide a water seal between the inlet 14 and the outlet 16 when the trap is in use. The insert is non-removably secured to the body.

Abstract: This invention relates to phosphate prodrugs of a farnesylated dibenzodiazepinone, to processes of their manufacture, to pharmaceutical compositions comprising the prodrugs, and to their use in the treatment of neoplasms.

Abstract: Described are methods and systems for identifying a secondary metabolite synthesized by a target gene cluster within a microorganism. A putative or confirmed function is attributed to a gene within the gene cluster, and an extract from the microorganism is obtained which is suspected to contain the secondary metabolite synthesized by the gene cluster. The extract is then assessed for chemical, physical or biological properties, and the metabolite is identified and optionally isolated. Further, the invention provides a knowledge repository in which gene cluster information is linked to secondary metabolite production data. The invention further relates to a graphical user interface for accessing the knowledge repository, and a memory for storing data, having a data structure that is stored in the memory.

Abstract: A mechanically-actuable combined seal and strainer plug (10) is provided. The plug (10) includes a length-adjustable stem (20a), (20b), which carries a seal (28) and a strainer (30). In use the strainer (30) is located above the seal (28), to permit easy access and cleaning. The stem (20a), (20b) is received in a waste outlet. The length of the stem may be adjusted by exertion of force on a knob (32) on the upper surface of the strainer (30); as the stem changes in length, the seal (28) engages and disengages with a surface of a waste outlet. When the seal (28) is disengaged, waste water can flow through the outlet passing first through the strainer (30) to remove solid particles.

Abstract: This invention relates to novel biologically active polycyclic aromatics produced by cultivation of Micromonospora echinospora ssp. challisensis NRRL 12255. The invention also relates to their pharmaceutically acceptable salts, prodrugs and derivatives, and to methods of obtaining them by post-biosynthesis chemical modification. The invention further relates to the use of the polycyclic aromatics and their derivatives in the preparation of medicaments for the treatment of neoplastic conditions and bacterial infections.

Abstract: A urinal outlet assembly comprises a urinal outlet pipe and a connector for coupling the outlet pipe to a waste pipe inlet. The connector is adapted to receive the outlet pipe in a sliding sealing fit.

Abstract: This invention relates to methods of inhibiting growth and/or proliferation of a neoplastic cell, and methods of treating neoplasms using the farnesylated dibenzodiazepinone compound of Formula I.

Abstract: The invention relates to biologically active dibenzodiazepinone analogs represented by Formula I, to methods of producing them, to pharmaceutical compositions comprising them and to methods of treating neoplastic conditions.

Abstract: The invention relates to biologically active dibenzodiazepinone analogs represented by Formula I, to methods of producing them, to pharmaceutical compositions comprising them and to methods of treating neoplastic conditions.

Abstract: This invention relates to a new class of polyene polyketides, their pharmaceutically acceptable salts and derivatives, and to methods for obtaining the compounds. One method of obtaining these compounds is by cultivation of novel strains of Streptomyces aizunensis; another method involves expression of biosynthetic pathway genes in transformed host cells. The present invention further relates to the novel strains of Streptomyces aizunensis used to produce these compounds, to the use of these compounds and their pharmaceutically acceptable salts and derivatives as pharmaceuticals, in particular to their use as inhibitors of fungal cell growth and cancer cell growth. The invention also relates to pharmaceutical compositions comprising these novel polyketides or a pharmaceutically acceptable salts or derivatives thereof. Finally, the invention relates to novel polynucleotide sequences and their encoded proteins, which are involved in the biosynthesis of these novel polyketides.