Patents by Inventor James McCabe
James McCabe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230241846Abstract: Packaging apparatus comprises two counter-rotatable sealing dies for pressing together two tissue webs to produce pockets for containing a substance for preparing beverages and to seal around said pockets, and two heating drums for heating the sealing dies and each being positioned inside a respective sealing die, wherein a first heating zone of each heating drum comprises a first plurality of circumferentially distributed infrared heating elements, and a second heating zone of each heating drum comprises a second plurality of circumferentially distributed infrared heating elements.Type: ApplicationFiled: June 11, 2021Publication date: August 3, 2023Applicant: TATA CONSUMER PRODUCTS GB LIMITEDInventors: ANDREW JOHN BISHOP, NEAL JAMES MCCABE, GARY ROBINSON, JOHN FRANCIS MCGOWAN, JASON SHAWN LEE EXLEY
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Publication number: 20220119372Abstract: Disclosed are compounds of formula (I), pharmaceutical compositions comprising such compounds and methods/uses of using the same, for example, for treating a JAK-related disorder, such as cancer, cancer cachexia or an immune disorder: wherein R1 is methyl or ethyl; R2 is selected from methyl, ethyl, methoxy and ethoxy; R3 is selected from hydrogen, chlorine, fluorine, bromine and methyl; R4 is selected from methyl, ethyl and —CH2OCH3; R5 and R6 are each individually methyl or hydrogen; and R7 is selected from methyl, ethyl, —(CH2)2OH and —(CH2)2OCH3, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: December 28, 2021Publication date: April 21, 2022Inventors: Annika Birgitta Margareta ASTRAND, Neil Patrick GRIMSTER, Sameer KAWATKAR, Jason Grant KETTLE, Magnus K. NILSSON, Linette RUSTON, Qibin SU, Melissa VASBINDER, Jon James WINTER-HOLT, Richard Donald WOESSNER, Claudio Edmundo CHUAQUI, James MCCABE
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Patent number: 11247983Abstract: Disclosed are compounds of formula (I), pharmaceutical compositions comprising such compounds and methods/uses of using the same, for example, for treating a JAK-related disorder, such as cancer, cancer cachexia or an immune disorder: wherein R1 is methyl or ethyl; R2 is selected from methyl, ethyl, methoxy and ethoxy; R3 is selected from hydrogen, chlorine, fluorine, bromine and methyl; R4 is selected from methyl, ethyl and —CH2OCH3; R5 and R6 are each individually methyl or hydrogen; and R7 is selected from methyl, ethyl, —(CH2)2OH and —(CH2)2OCH3, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: April 28, 2020Date of Patent: February 15, 2022Assignee: Dizal (Jiangsu) Pharmaceutical Co., Ltd.Inventors: Annika Birgitta Margareta Astrand, Neil Patrick Grimster, Sameer Kawatkar, Jason Grant Kettle, Magnus K. Nilsson, Linette Ruston, Qibin Su, Melissa Vasbinder, Jon James Winter-Holt, Richard Donald Woessner, Claudio Edmundo Chuaqui, James McCabe
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Patent number: 11149029Abstract: The present disclosure relates to salts of compounds of Formula (I) prepared as a xinafoate (1-hydroxy-2-naphthoate) salt (Formula (Ia)), pharmaceutically acceptable compositions comprising same and methods of using the same.Type: GrantFiled: July 17, 2019Date of Patent: October 19, 2021Assignee: AstraZeneca ABInventors: Anna Matilda Angelica Pettersen, James McCabe, Carl-Johan Aurell
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Publication number: 20210078981Abstract: Disclosed are compounds of formula (I), pharmaceutical compositions comprising such compounds and methods/uses of using the same, for example, for treating a JAK-related disorder, such as cancer, cancer cachexia or an immune disorder: wherein R1 is methyl or ethyl; R2 is selected from methyl, ethyl, methoxy and ethoxy; R3 is selected from hydrogen, chlorine, fluorine, bromine and methyl; R4 is selected from methyl, ethyl and —CH2OCH3; R5 and R6 are each individually methyl or hydrogen; and R7 is selected from methyl, ethyl, —(CH2)2OH and —(CH2)2OCH3, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: April 28, 2020Publication date: March 18, 2021Applicant: Dizal (Jiangsu) Pharmaceutical Co., Ltd.Inventors: Annika Birgitta Margareta ASTRAND, Neil Patrick GRIMSTER, Sameer KAWATKAR, Jason Grant KETTLE, Magnus K. NILSSON, Linette RUSTON, Qibin SU, Melissa VASBINDER, Jon James WINTER-HOLT, Richard Donald WOESSNER, Claudio Edmundo CHUAQUI, James MCCABE
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Patent number: 10654835Abstract: Disclosed are compounds of formula (I), pharmaceutical compositions comprising such compounds and methods/uses of using the same, for example, for treating a JAK-related disorder, such as cancer, cancer cachexia or an immune disorder: wherein R1 is methyl or ethyl; R2 is selected from methyl, ethyl, methoxy and ethoxy; R3 is selected from hydrogen, chlorine, fluorine, bromine and methyl; R4 is selected from methyl, ethyl and —CH2OCH3; R5 and R6 are each individually methyl or hydrogen; and R7 is selected from methyl, ethyl, —(CH2)2OH and —(CH2)2OCH3, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: November 20, 2018Date of Patent: May 19, 2020Assignee: Dizal (Jiangsu) Pharmaceutical Co., Ltd.Inventors: Annika Birgitta Margareta Astrand, Neil Patrick Grimster, Sameer Kawatkar, Jason Grant Kettle, Magnus K. Nilsson, Linette Ruston, Qibin Su, Melissa Vasbinder, Jon James Winter-Holt, Richard Donald Woessner, Claudio Edmundo Chuaqui, James McCabe
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Publication number: 20200062737Abstract: The present disclosure relates to salts of compounds of Formula (I) prepared as a xinafoate (1-hydroxy-2-naphthoate) salt (Formula (Ia)), pharmaceutically acceptable compositions comprising same and methods of using the same.Type: ApplicationFiled: July 17, 2019Publication date: February 27, 2020Inventors: Anna Matilda Angelica PETTERSEN, James MCCABE, Carl-Johan AURELL
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Publication number: 20190375730Abstract: The present invention relates to AZD2171 maleate salt, to particular crystalline forms of AZD2171 maleate salt, to processes for their preparation, to pharmaceutical compositions containing them as active ingredient, to their use in the manufacture of medicaments for use in the production of antiangiogenic and/or vascular permeability reducing effects in warm-blooded animals such as humans, and to their use in methods for the treatment of disease states associated with angiogenesis and/or increased vascular permeability.Type: ApplicationFiled: January 4, 2019Publication date: December 12, 2019Applicant: AstraZeneca ABInventor: James MCCABE
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Patent number: 10472800Abstract: An apparatus for backfilling a trench and, more particularly, an apparatus for laying a pipeline bed layer in a trench and for laying a pipeline bedding layer once a pipeline is laid in the trench. The apparatus comprises a multi-deck screen vibrating unit. The upper deck screen comprises finger tines or a grizzly arrangement.Type: GrantFiled: March 31, 2017Date of Patent: November 12, 2019Assignee: DELTA PIPELINE MACHINERY, B.V.Inventor: Keith James McCabe
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Patent number: 10468223Abstract: An X-ray tube is provided. The X-ray tube includes a bearing configured to couple to an anode. The bearing includes a stationary member, a rotary member configured to rotate with respect to the stationary member during operation of the X-ray tube, and a support feature configured to minimize bending moment along a surface of the stationary member to reduce deflection of the stationary member relative to the rotary member due to radial loads during operation of the X-ray tube.Type: GrantFiled: January 4, 2019Date of Patent: November 5, 2019Assignee: GENERAL ELECTRIC COMPANYInventors: John James McCabe, Michael Scott Hebert, Ian Strider Hunt, Andrew Thomas Triscari, Kevin Shane Kruse, Alxander Thomas Ryan, Adolfo Delgado Marquez
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Publication number: 20190139732Abstract: An X-ray tube is provided. The X-ray tube includes a bearing configured to couple to an anode. The bearing includes a stationary member, a rotary member configured to rotate with respect to the stationary member during operation of the X-ray tube, and a support feature configured to minimize bending moment along a surface of the stationary member to reduce deflection of the stationary member relative to the rotary member due to radial loads during operation of the X-ray tube.Type: ApplicationFiled: January 4, 2019Publication date: May 9, 2019Inventors: John James McCabe, Michael Scott Hebert, Ian Strider Hunt, Andrew Thomas Triscari, Kevin Shane Kruse, Alxander Thomas Ryan, Adolfo Delgado Marquez
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Patent number: 10283312Abstract: An X-ray tube is provided. The X-ray tube includes a bearing configured to couple to an anode. The bearing includes a stationary member, a rotary member configured to rotate with respect to the stationary member during operation of the X-ray tube, and a support feature configured to minimize bending moment along a surface of the stationary member to reduce deflection of the stationary member relative to the rotary member due to radial loads during operation of the X-ray tube.Type: GrantFiled: August 30, 2016Date of Patent: May 7, 2019Assignee: GENERAL ELECTRIC COMPANYInventors: John James McCabe, Michael Scott Hebert, Ian Strider Hunt, Andrew Thomas Triscari, Kevin Shane Kruse, Alexander Thomas Ryan, Adolfo Delgado Marquez
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Publication number: 20190112785Abstract: An apparatus for backfilling a trench and, more particularly, an apparatus for laying a pipeline bed layer in a trench and for laying a pipeline bedding layer once a pipeline is laid in the trench. The apparatus comprises a multi-deck screen vibrating unit. The upper deck screen comprises finger tines or a grizzly arrangement.Type: ApplicationFiled: March 31, 2017Publication date: April 18, 2019Applicant: DELTA PIPELINE MACHINERY B.V.Inventor: Keith James MCCABE
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Publication number: 20190092760Abstract: Disclosed are compounds of formula (I), pharmaceutical compositions comprising such compounds and methods/uses of using the same, for example, for treating a JAK-related disorder, such as cancer, cancer cachexia or an immune disorder: wherein R1 is methyl or ethyl; R2 is selected from methyl, ethyl, methoxy and ethoxy; R3 is selected from hydrogen, chlorine, fluorine, bromine and methyl; R4 is selected from methyl, ethyl and —CH2OCH3; R5 and R6 are each individually methyl or hydrogen; and R7 is selected from methyl, ethyl, —(CH2)2OH and —(CH2)2OCH3, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: November 20, 2018Publication date: March 28, 2019Applicant: Dizal (Jiangsu) Pharmaceutical Co., Ltd.Inventors: Annika ASTRAND, Neil GRIMSTER, Sameer KAWATKAR, Jason Grant KETTLE, Magnus K NILSSON, Linette RUSTON, Qibin SU, Melissa VASBINDER, Jon James WINTER-HOLT, Richard Donald WOESSNER, Claudio Edmundo CHUAQUI, James MCCABE
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Patent number: 10167276Abstract: Disclosed are compounds of formula (I), pharmaceutical compositions comprising such compounds and methods/uses of using the same, for example, for treating a JAK-related disorder, such as cancer, cancer cachexia or an immune disorder: wherein R1 is methyl or ethyl; R2 is selected from methyl, ethyl, methoxy and ethoxy; R3 is selected from hydrogen, chlorine, fluorine, bromine and methyl; R4 is selected from methyl, ethyl and —CH2OCH3; R5 and R6 are each individually methyl or hydrogen; and R7 is selected from methyl, ethyl, —(CH2)2OH and —(CH2)2OCH3, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: May 22, 2017Date of Patent: January 1, 2019Assignee: Dizal (Jiangsu) Pharmaceutical Co., Ltd.Inventors: Annika Astrand, Neil Grimster, Sameer Kawatkar, Jason Grant Kettle, Magnus K Nilsson, Linette Ruston, Qibin Su, Melissa Vasbinder, Jon James Winter-Holt, Richard Donald Woessner, Claudio Edmundo Chuaqui, James McCabe
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Publication number: 20180170913Abstract: The present invention relates to AZD2171 maleate salt, to particular crystalline forms of AZD2171 maleate salt, to processes for their preparation, to pharmaceutical compositions containing them as active ingredient, to their use in the manufacture of medicaments for use in the production of antiangiogenic and/or vascular permeability reducing effects in warm-blooded animals such as humans, and to their use in methods for the treatment of disease states associated with angiogenesis and/or increased vascular permeability.Type: ApplicationFiled: December 28, 2017Publication date: June 21, 2018Applicant: AstraZeneca ABInventor: James MCCABE
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Publication number: 20180061611Abstract: An X-ray tube is provided. The X-ray tube includes a bearing configured to couple to an anode. The bearing includes a stationary member, a rotary member configured to rotate with respect to the stationary member during operation of the X-ray tube, and a support feature configured to minimize bending moment along a surface of the stationary member to reduce deflection of the stationary member relative to the rotary member due to radial loads during operation of the X-ray tube.Type: ApplicationFiled: August 30, 2016Publication date: March 1, 2018Inventors: John James McCabe, Michael Scott Hebert, Ian Strider Hunt, Andrew Thomas Triscari, Kevin Shane Kruse, Alexander Thomas Ryan, Adolfo Delgado Marquez
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Patent number: 9890140Abstract: The present invention relates to AZD2171 maleate salt, to particular crystalline forms of AZD2171 maleate salt, to processes for their preparation, to pharmaceutical compositions containing them as active ingredient, to their use in the manufacture of medicaments for use in the production of antiangiogenic and/or vascular permeability reducing effects in warm-blooded animals such as humans, and to their use in methods for the treatment of disease states associated with angiogenesis and/or increased vascular permeability.Type: GrantFiled: September 13, 2016Date of Patent: February 13, 2018Assignee: ASTRAZENECA ABInventor: James McCabe
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Publication number: 20170320857Abstract: Disclosed are compounds of formula (I), pharmaceutical compositions comprising such compounds and methods/uses of using the same, for example, for treating a JAK-related disorder, such as cancer, cancer cachexia or an immune disorder: wherein R1 is methyl or ethyl; R2 is selected from methyl, ethyl, methoxy and ethoxy; R3 is selected from hydrogen, chlorine, fluorine, bromine and methyl; R4 is selected from methyl, ethyl and —CH2OCH3; R5 and R6 are each individually methyl or hydrogen; and R7 is selected from methyl, ethyl, —(CH2)2OH and —(CH2)2OCH3, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: May 22, 2017Publication date: November 9, 2017Applicant: AstraZeneca ABInventors: Annika ASTRAND, Neil GRIMSTER, Sameer KAWATKAR, Jason Grant KETTLE, Magnus K NILSSON, Linette RUSTON, Qibin SU, Melissa VASBINDER, Jon James WINTER-HOLT, Richard Donald WOESSNER, Claudio Edmundo CHUAQUI, James MCCABE
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Publication number: 20170088543Abstract: Disclosed are compounds of formula (I), pharmaceutical compositions comprising such compounds and methods/uses of using the same, for example, for treating a JAK-related disorder, such as cancer, cancer cachexia or an immune disorder: wherein R1 is methyl or ethyl; R2 is selected from methyl, ethyl, methoxy and ethoxy; R3 is selected from hydrogen, chlorine, fluorine, bromine and methyl; R4 is selected from methyl, ethyl and —CH2OCH3; R5 and R6 are each individually methyl or hydrogen; and R7 is selected from methyl, ethyl, —(CH2)2OH and —(CH2)2OCH3, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: September 22, 2016Publication date: March 30, 2017Applicant: AstraZeneca ABInventors: Annika ASTRAND, Neil GRIMSTER, Sameer KAWATKAR, Jason Grant KETTLE, Magnus K. NILSSON, Linette RUSTON, Qibin SU, Melissa VASBINDER, Jon James WINTER-HOLT, Richard Donald WOESSNER, Claudio Edmundo CHUAQUI, Dedong WU, Wenzhan YANG, Tudor GRECU, James MCCABE