Abstract: The present ventilator system, for detecting and treating concurrent chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA event(s)) overlap syndrome, comprises a pressure generator for generating a pressurized flow of breathable gas for delivery to an airway of a subject; sensor(s) for generating output signals conveying information related to breathable gas parameters; and processor(s) operatively connected to the sensor(s) and the pressure generator, configured to: detect presence of OSA event(s) and/or expiratory flow limitation (EFL) in the subject based on the output signals.

Abstract: The invention provides a method of identifying a peptide interaction site on a target protein wherein the target protein modulates the phenotype of a mammalian cell, using mammalian encoded peptides (SEPs) such as short open reading frame (sORF) encoded peptides. The invention further provides a method for the identification of new therapeutic targets and protein interaction sites for use in drug discovery.

Abstract: A fluid circuit includes a plurality of tubing segments and a plurality of operative components. Each tubing segment includes i) a non-conductive polymer portion defining a fluid passageway and ii) one or more interior conductive fluoropolymer stripes extending axially to the ends of each of the respective tubing segments. Each operative component includes a conductive fluoropolymer that extends between a plurality of tubing connector fittings forming a part of the fluid circuit, wherein each of the tubing connector fittings conductively connect the respective conductor of the operative component to the interior conductive fluoropolymer stripes of the tubing segment to provide a path to ground that extends through each operative component and each tubing segment.

Abstract: In certain embodiments, a ventilator may provide interactive guidance for obtaining a subject's expiratory flow limitation results. In some embodiments, the ventilator may cause a progressive color component to be presented, where the progressive color component indicates a progression from one color proximate one side of the progressive color component to another color proximate another side of the progressive color component. The ventilator may cause a forced oscillation to be continuously applied to an airway of the subject for a time period. The ventilator may monitor the subject's degree of expiratory flow limitation based on output signals generated by one or more sensors as the forced oscillation is continuously applied for the time period. The ventilator may cause, based on the monitoring, a movable component's position on the progressive color component to be continuously updated during the time period to indicate the degree of expiratory flow limitation.

Abstract: A fluid circuit includes a plurality of tubing segments and a plurality of operative components. Each tubing segment includes i) a non-conductive polymer portion defining a fluid passageway and ii) one or more interior conductive fluoropolymer stripes extending axially to the ends of each of the respective tubing segments. Each operative component includes a conductive fluoropolymer that extends between a plurality of tubing connector fittings forming a part of the fluid circuit, wherein each of the tubing connector fittings conductively connect the respective conductor of the operative component to the interior conductive fluoropolymer stripes of the tubing segment to provide a path to ground that extends through each operative component and each tubing segment.

Abstract: Approaches for monitoring a host operating system. A threat model is stored and maintained in an isolated execution environment. The threat model identifies for any process executing on a host operating system how trustworthy the process should be deemed based on a pattern of observed behavior. The execution of the process and those processes in a monitoring circle relationship thereto are monitored. The monitoring circle relationship includes a parent process, any process in communication with a member of monitoring circle relationship, and any process instantiated by a present member of monitoring circle relationship. Observed process behavior is correlated with the threat model. Upon determining that a particular process has behaved in a manner inconsistent with a pattern of allowable behavior identified by the threat model for that process, a responsive action is taken.

Abstract: The invention provides a method of identifying a peptide interaction site on a target protein wherein the target protein modulates the phenotype of a mammalian cell, using mammalian encoded peptides (SEPs) such as short open reading frame (sORF) encoded peptides. The invention further provides a method for the identification of new therapeutic targets and protein interaction sites for use in drug discovery.

Abstract: The present invention relates to a composition and uses thereof. The invention relates to a composition for use in stimulating neoantigen production in a cancerous tumour. In particular, the composition comprises a compound or a pharmaceutically acceptable salt thereof, wherein the composition is a negative modulator of the expression, function or stability of ribonucleotide reductase.

Abstract: The invention provides a method of identifying a peptide interaction site on a target protein wherein the target protein modulates the phenotype of a mammalian cell, using mammalian encoded peptides (SEPs) such as short open reading frame (sORF) encoded peptides. The invention further provides a method for the identification of new therapeutic targets and protein interaction sites for use in drug discovery.

Abstract: The present ventilator system, for detecting and treating concurrent chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA event(s)) overlap syndrome, comprises a pressure generator for generating a pressurized flow of breathable gas for delivery to an airway of a subject; sensor(s) for generating output signals conveying information related to breathable gas parameters; and processor(s) operatively connected to the sensor(s) and the pressure generator, configured to: detect presence of OSA event(s) and/or expiratory flow limitation (EFL) in the subject based on the output signals.

Abstract: Approaches for monitoring a host operating system. A threat model is stored and maintained in an isolated execution environment. The threat model identifies for any process executing on a host operating system how trustworthy the process should be deemed based on a pattern of observed behavior. The execution of the process and those processes in a monitoring circle relationship thereto are monitored. The monitoring circle relationship includes a parent process, any process in communication with a member of monitoring circle relationship, and any process instantiated by a present member of monitoring circle relationship. Observed process behavior is correlated with the threat model. Upon determining that a particular process has behaved in a manner inconsistent with a pattern of allowable behavior identified by the threat model for that process, a responsive action is taken.

Abstract: A humidifier for an airway pressure support system, includes a base, a number of side walls extending from the base, and a top wall provided opposite the base, wherein the base, the number of side walls, and the top wall are made from an elastomeric material and at least partially define an internal chamber for receiving and holding a liquid. The humidifier also includes a plurality of support structures provided on or within the humidifier, each support structure extending along at least the number of side walls, wherein the humidifier is structured to collapse from an initial, expanded condition to a collapsed condition when a compressive force is applied to the top wall in the initial, expanded condition and to automatically return to the initial, expanded condition when the force is removed.

Abstract: The present patent application discloses a system that includes a pressure generator; one or more sensors configured to generate output signals conveying information related to one or more parameters of a pressurized flow of breathable gas to an airway of the subject and respiration of the subject; and one or more hardware processors configured by machine readable instructions to: determine the one or more parameters of the pressurized flow of breathable gas and the respiration of the subject based on the information in the output signals; determine one or more indices of respiratory impedance for the airway of the subject based on the determined parameters; determine a change in health status of the subject based on the one or more indices of respiratory impedance; and generate an alert indicative of the change in health status for communication to the subject and/or a caregiver of the subject.

Abstract: A current mode switching regulator circuit and operating method includes a variable duty cycle power switch controller, a voltage feedback loop that provides a feedback signal based on the output voltage, a current feedback loop that provides a current sense signal based on the output current, and an offset circuit having an external signal input and coupled to the current feedback loop. The power switch controller controls the switching regulator circuit to generate an output voltage and an output current. The offset circuit is configured to provide an offset output control signal, independently of the voltage feedback loop, to control the power switch controller so as to vary a duty cycle of the power switch controller based on the current sense signal and an external offset signal applied to the external signal input.

Abstract: A fluid circuit includes a plurality of tubing segments and a plurality of operative components. Each tubing segment includes i) a non-conductive polymer portion defining a fluid passageway and ii) one or more interior conductive fluoropolymer stripes extending axially to the ends of each of the respective tubing segments. Each operative component includes a conductive fluoropolymer that extends between a plurality of tubing connector fittings forming a part of the fluid circuit, wherein each of the tubing connector fittings conductively connect the respective conductor of the operative component to the interior conductive fluoropolymer stripes of the tubing segment to provide a path to ground that extends through each operative component and each tubing segment.

Abstract: In certain embodiments, a ventilator may provide interactive guidance for obtaining a subject's expiratory flow limitation results. In some embodiments, the ventilator may cause a progressive color component to be presented, where the progressive color component indicates a progression from one color proximate one side of the progressive color component to another color proximate another side of the progressive color component. The ventilator may cause a forced oscillation to be continuously applied to an airway of the subject for a time period. The ventilator may monitor the subject's degree of expiratory flow limitation based on output signals generated by one or more sensors as the forced oscillation is continuously applied for the time period. The ventilator may cause, based on the monitoring, a movable component's position on the progressive color component to be continuously updated during the time period to indicate the degree of expiratory flow limitation.

Abstract: Contemplated methods and devices are drawn to preparation and analysis of analytes from biological samples. In a preferred embodiment the analytes are nucleic acids that are both released from biological compartments present in the sample and fragmented through the use of a voltage potential applied to a pair of electrodes. The nucleic acids thus prepared are subsequently characterized.

Abstract: The invention provides a method of identifying a peptide interaction site on a target protein wherein the target protein modulates the phenotype of a mammalian cell, using mammalian encoded peptides (SEPs) such as short open reading frame (sORF) encoded peptides. The invention further provides a method for the identification of new therapeutic targets and protein interaction sites for use in drug discovery.

Abstract: A humidifier (68, 68?, 100, 100?) for an airway pressure support system (50), includes a base (70, 102), a number of side walls (76, 78, 104) extending from the base, and a top wall (80, 106) provided opposite the base, wherein the base, the number of side walls, and the top wall are made form an elastomeric material and at least partially define an internal chamber (82) for receiving and holding a liquid. The humidifier also includes a plurality of support structures (88, 88?, 112, 114, 118, 120) provided on or within the humidifier, each support structure extending along at least the number of side walls, wherein the humidifier is structured to collapse from an initial, expanded condition to a collapsed condition when a compressive force is applied to the top wall in the initial, expanded condition and to automatically return to the initial, expanded condition when the force is removed.

Abstract: Contemplated methods and devices are drawn to preparation and analysis of analytes from biological samples. In a preferred embodiment the analytes are nucleic acids that are both released from biological compartments present in the sample and fragmented through the use of a voltage potential applied to a pair of electrodes. The nucleic acids thus prepared are subsequently characterized.