Patents by Inventor James McKerrow

James McKerrow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTILEISHMANIAL COMPOUNDS, COMPOSITIONS AND USE THEREOF
    Publication number: 20230381142
    Abstract: Provided herein are antileishmanial compounds, compositions comprising the antileishmanial compounds, and use thereof.
    Type: Application
    Filed: May 25, 2023
    Publication date: November 30, 2023
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Scott E. SCHAUS, Lauren E. BROWN, Mark W. GRINSTAFF, Danielle M. FITZGERALD, Diana L. DIAZ, John A. KAVOURIS, Jair LAGE DE SIQUEIRA-NETO, James MCKERROW, Camila INDIANI DE OLIVEIRA
  • ANTI-PARASITIC COMPOUNDS AND USES THEREOF
    Publication number: 20220340557
    Abstract: The present disclosure provides compounds of Formula (I?), Formula (II), and Formula (III). The compounds described herein may useful in treating and/or preventing protozoan infections in a subject in need thereof, treating and/or preventing trypanosomal infections (e.g., Trypanosoma cruzi (T. cruzi) or Trypanosoma brucei infections) and/or plasmodial infections in a subject in need thereof, treating and/or preventing diseases in a subject in need thereof (e.g., Chagas disease, malaria, and/or sleeping sickness), and may be useful in treating and/or preventing infectious diseases in a subject in need thereof. Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including a compound described herein.
    Type: Application
    Filed: November 22, 2021
    Publication date: October 27, 2022
    Applicants: Memorial Sloan-Kettering Cancer Center, The Regents of the University of California, University of Central Florida Research Foundation, Inc., The Broad Institute, Inc.
    Inventors: Derek Shieh Tan, Corinne N. Foley, Gustavo Moura-Letts, James McKerrow, Sivaraman Dandapani, Rahul Edwankar, Alyssa Verano, Debopam Chakrabarti, Bracken Roberts
  • Anti-parasitic compounds and uses thereof
    Patent number: 11180492
    Abstract: The present disclosure provides compounds of Formula (I?), Formula (II), and Formula (III). The compounds described herein may useful in treating and/or preventing protozoan infections in a subject in need thereof, treating and/or preventing trypanosomal infections (e.g., Trypanosoma cruzi (T. cruzi) or Trypanosoma brucei infections) and/or plasmodial infections in a subject in need thereof, treating and/or preventing diseases in a subject in need thereof (e.g., Chagas disease, malaria, and/or sleeping sickness), and may be useful in treating and/or preventing infectious diseases in a subject in need thereof. Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including a compound described herein.
    Type: Grant
    Filed: January 17, 2017
    Date of Patent: November 23, 2021
    Assignees: University of Central Florida Research Foundation, Inc., The Regents of the University of California, Memorial Sloan-Kettering Cancer Center, The Broad Institute, Inc.
    Inventors: Derek Shieh Tan, Corinne N. Foley, Gustavo Moura-Letts, James McKerrow, Sivaraman Dandapani, Rahul Edwankar, Alyssa Verano, Debopam Chakrabarti, Bracken Roberts
  • ANTI-PARASITIC COMPOUNDS AND USES THEREOF
    Publication number: 20190002463
    Abstract: The present disclosure provides compounds of Formula (I?), Formula (II), and Formula (III). The compounds described herein may useful in treating and/or preventing protozoan infections in a subject in need thereof, treating and/or preventing trypanosomal infections (e.g., Trypanosoma cruzi (T. cruzi) or Trypanosoma brucei infections) and/or plasmodial infections in a subject in need thereof, treating and/or preventing diseases in a subject in need thereof (e.g., Chagas disease, malaria, and/or sleeping sickness), and may be useful in treating and/or preventing infectious diseases in a subject in need thereof. Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including a compound described herein.
    Type: Application
    Filed: January 17, 2017
    Publication date: January 3, 2019
    Applicants: Memorial Sloan-Kettering Cancer Center, The Regents of The University of California, University of Central Florida Research Foundation, Inc., The Broad Institute, Inc.
    Inventors: Derek Shieh Tan, Corinne N. Foley, Gustavo Moura-Letts, James McKerrow, Sivaraman Dandapani, Rahul Edwankar, Alyssa Verano, Debopam Chakrabarti, Braken Roberts
  • Methods for making and using novel semi-synthetic small molecules for the treatment parasitic disease
    Patent number: 9290474
    Abstract: Small molecule therapeutics for the treatment of parasitic diseases, in particular, semi-synthetic derivatives of the fungally-derived natural product merulin A for the treatment of African Sleeping Sickness.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: March 22, 2016
    Assignee: The Regents of the University of California
    Inventors: Roger R Linington, Gabriel Navarro, Khanitha Pudhom, James McKerrow
  • Methods for making and using novel semi-synthetic small molecules for the treatment parasitic disease
    Publication number: 20150105453
    Abstract: Small molecule therapeutics for the treatment of parasitic diseases, in particular, semi-synthetic derivatives of the fugally-derived natural product merulin A for the treatment of African Sleeping Sickness.
    Type: Application
    Filed: December 17, 2014
    Publication date: April 16, 2015
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Roger R Linington, Gabriel Navarro, Khanitha Pudhom, James McKerrow
  • Semi-synthetic small molecules for the treatment parasitic disease
    Patent number: 8946455
    Abstract: Small molecule therapeutics for the treatment of parasitic diseases, in particular, semi-synthetic derivatives of the fugally-derived natural product merulin A for the treatment of African Sleeping Sickness.
    Type: Grant
    Filed: July 28, 2012
    Date of Patent: February 3, 2015
    Assignee: Regents of the University of California
    Inventors: Roger Linington, Gabriel Navarro, Khanitha Pudhom, James McKerrow
  • Novel semi-synthetic small molecules for the treatment parasitic disease
    Publication number: 20140296531
    Abstract: Small molecule therapeutics for the treatment of parasitic diseases, in particular, semi-synthetic derivatives of the fugally-derived natural product merulin A for the treatment of African Sleeping Sickness.
    Type: Application
    Filed: July 28, 2012
    Publication date: October 2, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Khanitha Pudhom, Gabriel Navarro, James McKerrow, Roger Linington
  • Thio semicarbazone and semicarbozone inhibitors of cysteine proteases and methods of their use
    Publication number: 20050182121
    Abstract: The present invention relates to thio semicarbazone and semicarbazone inhibitors of cysteine proteases and methods of using such compounds to prevent and treat protozoan infections such as trypanosomiasis, malaria and leishmaniasis. The compounds also find use in inhibiting cysteine proteases associated with carcinogenesis, including cathepsins B and L.
    Type: Application
    Filed: March 18, 2005
    Publication date: August 18, 2005
    Applicant: The Regents of the University of California
    Inventors: Fred Cohen, Xiaohui Du, Chun Guo, James McKerrow