Patents by Inventor James McLinden

James McLinden has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Viral RNA segments as immunomodulatory agents and vaccine components
    Patent number: 10493141
    Abstract: The disclosure provides compositions and methods involving viral RNA segments for use in modulating immune responses, including inhibition inflammation related to pathogenic T-cell activation. In addition, modification of the viral sequences responsible for modulating immune response provides for improved vaccine formulations.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: December 3, 2019
    Assignee: THE UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Jack T. Stapleton, Nirjal Bhattarai, James McLinden, Jinhau Xiang, Bev Davidson
  • VIRAL RNA SEGMENTS AS IMMUNOMODULATORY AGENTS AND VACCINE COMPONENTS
    Publication number: 20180000925
    Abstract: The disclosure provides compositions and methods involving viral RNA segments for use in modulating immune responses, including inhibition inflammation related to pathogenic T-cell activation. In addition, modification of the viral sequences responsible for modulating immune response provides for improved vaccine formulations.
    Type: Application
    Filed: September 9, 2015
    Publication date: January 4, 2018
    Applicant: THE UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Jack T. STAPLETON, Nirjal BHATTARAI, James MCLINDEN, Jinhau XIANG, Bev DAVIDSON
  • Flavivirus NS5A proteins for the treatment of HIV
    Patent number: 8268778
    Abstract: GB virus C (GBV-C or hepatitis G virus) is a flavivirus that frequently leads to chronic viremia in humans. The invention provides compositions and methods involving a -GBV-C NS5A peptide or polypeptide for inhibiting and treating HIV infections.
    Type: Grant
    Filed: March 20, 2008
    Date of Patent: September 18, 2012
    Assignee: University of Iowa Research Foundation
    Inventors: James McLinden, Jinhua Xiang, Jack T. Stapleton
  • Flavivirus NS5A proteins for the treatment of HIV
    Patent number: 7951531
    Abstract: GB virus C (GBV-C or hepatitis G virus) is a flavivirus that frequently leads to chronic viremia in humans. The invention provides compositions and methods involving a-GBV-C NS5A peptide or polypeptide for inhibiting and treating HIV infections.
    Type: Grant
    Filed: February 1, 2006
    Date of Patent: May 31, 2011
    Assignee: University of Iowa Research Foundation
    Inventors: Jack T. Stapleton, Jinhua Xiang, Qing Chang, James McLinden
  • Flavivirus NS5A Proteins For the Treatment of HIV
    Publication number: 20100143454
    Abstract: GB virus C (GBV-C or hepatitis G virus) is a flavivirus that frequently leads to chronic viremia in humans. The invention provides compositions and methods involving a -GBV-C NS5A peptide or polypeptide for inhibiting and treating HIV infections.
    Type: Application
    Filed: March 20, 2008
    Publication date: June 10, 2010
    Inventors: James McLinden, Jinhua Xiang, Jack T. Stapleton
  • Flavivirus NS5A proteins for the treatment of HIV
    Publication number: 20070036825
    Abstract: GB virus C (GBV-C or hepatitis G virus) is a flavivirus that frequently leads to chronic viremia in humans. The invention provides compositions and methods involving a-GBV-C NS5A peptide or polypeptide for inhibiting and treating HIV infections.
    Type: Application
    Filed: February 1, 2006
    Publication date: February 15, 2007
    Inventors: Jack Stapleton, Jinhua Xiang, Qing Chang, James McLinden
  • GB virus C (hepatitis G virus) for the treatment of HIV
    Publication number: 20050118181
    Abstract: GB virus C (GBV-C or hepatitis G virus) is a flavivirus that frequently leads to chronic viremia in humans. The invention provides compositions and methods involving an anti-GBV-C antibody or other GBV-C binding agent, or a GBV-C antigen, for inhibiting and treating HIV infections.
    Type: Application
    Filed: June 4, 2004
    Publication date: June 2, 2005
    Inventors: Jack Stapleton, Jinhua Xiang, Donna Klinzman, James McLinden