Patents by Inventor James McMichael
James McMichael has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8728485Abstract: The present invention provides artificial fusion proteins (AFPs) designed to elicit an anti-HIV immune response, as well as nucleic acid molecules and expression vectors encoding those proteins. The AFPs of the invention may comprise domains from various HIV proteins, such as Gag, Pol, Vif, and Env proteins, which are partial sequences. HIVCON is an AFP in which the HIV domains are from several HIV Glade consensus sequences and which optionally contains additional domains which may be useful, for example, in monitoring expression levels or laboratory animal immune responses. Other aspects of the invention may include compositions and methods for inducing an anti-HIV immune response in a subject, preferably with a DNA prime-MVA boost strategy, and to induce a cell-mediated immune response.Type: GrantFiled: March 17, 2010Date of Patent: May 20, 2014Assignee: Medical Research CouncilInventors: Tomas Hanke, Andrew James McMichael
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Patent number: 7981430Abstract: The present invention provides artificial fusion proteins (AFPs) designed to elicit an anti-HIV immune response, as well as nucleic acid molecules and expression vectors encoding those proteins. The AFPs of the invention may comprise domains from various HIV proteins, such as Gag, Pol, Vif, and Env proteins, which are partial sequences. HIVCON is an AFP in which the HIV domains are from several HIV clade consensus sequences and which optionally contains additional domains which may be useful, for example, in monitoring expression levels or laboratory animal immune responses. Other aspects of the invention may include compositions and methods for inducing an anti-HIV immune response in a subject, preferably with a DNA prime-MVA boost strategy, and to induce a cell-mediated immune response.Type: GrantFiled: August 23, 2007Date of Patent: July 19, 2011Assignee: Medical Research CouncilInventors: Tomas Hanke, Andrew James McMichael
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Publication number: 20100266635Abstract: The present invention provides artificial fusion proteins (AFPs) designed to elicit an anti-HIV immune response, as well as nucleic acid molecules and expression vectors encoding those proteins. The AFPs of the invention may comprise domains from various HIV proteins, such as Gag, Pol, Vif, and Env proteins, which are partial sequences. HIVCON is an AFP in which the HIV domains are from several HIV Glade consensus sequences and which optionally contains additional domains which may be useful, for example, in monitoring expression levels or laboratory animal immune responses. Other aspects of the invention may include compositions and methods for inducing an anti-HIV immune response in a subject, preferably with a DNA prime-MVA boost strategy, and to induce a cell-mediated immune response.Type: ApplicationFiled: March 17, 2010Publication date: October 21, 2010Inventors: Tomas HANKE, Andrew James McMichael
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Publication number: 20080306244Abstract: The present invention provides artificial fusion proteins (AFPs) designed to elicit an anti-HIV immune response, as well as nucleic acid molecules and expression vectors encoding those proteins. The AFPs of the invention may comprise domains from various HIV proteins, including Reverse Trancriptase (RT), Env (gp41), Nef and Tat proteins, as well as at least one HIV CTL epitope associated with long-term, non-progression to AIDS; these domains are biologically-inactivated for one or more of the normal activity of those proteins or are partial protein sequences (and similarly biologically-inactivated). RENTA is an AFP in which the HIV domains are from an HIV Clade A consensus sequence and contains additional domains, useful for example, in monitoring expression levels or laboratory animal immune responses. Such domains are optionally included in the AFPs.Type: ApplicationFiled: May 12, 2006Publication date: December 11, 2008Inventors: Tomas Hanke, Andrew James McMichael
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Publication number: 20070034840Abstract: The present invention relates to substantially free-flowing polymer particles. The polymer particles are those which have a one millimeter penetration temperature of less than about 75° C. as determined by thermal mechanical analysis or an unconfined yield strength of greater than about 15 pounds per square foot (73 kilograms per square meter). The composition also comprises an effective amount of an anti-blocking agent in the presence or absence of a binding agent.Type: ApplicationFiled: October 17, 2006Publication date: February 15, 2007Applicant: Dow Global Technologies Inc.Inventors: James McMichael, Jeffrey Montanye, Friedhelm Bunge, Shrikant Dhodapkar
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Publication number: 20060241233Abstract: The present invention relates to substantially free-flowing polymer particles. The polymer particles are those which have a one millimeter penetration temperature of less than about 75° C. as determined by thermal mechanical analysis or an unconfined yield strength of greater than about 15 pounds per square foot (73 kilograms per square meter). The composition also comprises an effective amount of an anti-blocking agent in the presence or absence of a binding agent.Type: ApplicationFiled: June 1, 2006Publication date: October 26, 2006Applicant: The Dow Chemical CompanyInventors: James McMichael, Jeffrey Montayne, Shirkant Dhodapkar, Friedheim Bunge
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Publication number: 20050085581Abstract: The present invention relates to substantially free-flowing polymer particles. The polymer particles are those which have a one millimeter penetration temperature of less than about 75° C. as determined by thermal mechanical analysis or an unconfined yield strength of greater than about 15 pounds per square foot (73 kilograms per square meter). The composition also comprises an effective amount of an anti-blocking agent in the presence or absence of a binding agent.Type: ApplicationFiled: October 8, 2004Publication date: April 21, 2005Inventors: James McMichael, Jeffrey Montanye, Friedhelm Bunge, Shrikant Dhodapkar
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Publication number: 20040131598Abstract: The present invention relates to polynucleotides for use in cancer therapy. In particular, the invention provides a polynucleotide capable of expressing an epilope-&bgr;2m fusion protein; for use in the generation of cytotoxic T lymphocyte (CTL) responses against a tumour, and a polynucleotide capable of expressing an epitope-&bgr;2m fusion protein; for use in a method of restoring antigen presentation in the tumour of a host.Type: ApplicationFiled: July 30, 2003Publication date: July 8, 2004Inventors: Sabrina Tafuro, Ute-Christiane Meier, Andrew James McMichael, John Irving Bell, Guy Layton, Michael Hunter
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Patent number: 6186273Abstract: Each of a plurality of cargo holds of a bulk carrier vessel has a self-contained staging system lowered into it, from the platform track of which workers operate semi-automatic blasting machines that are mounted onto the platform. The set-up for each vessel also includes, for each hold, a ventilation unit provided on a hatch plug, and a transporter for the staging system. Groups of staging systems are served by on-deck air compressors. Staging systems actually engaging in blasting are served by recycling shot blast units which recycle and supply steel shot. Following blast cleaning, the cleaned surfaces are painted from the platforms.Type: GrantFiled: September 14, 1998Date of Patent: February 13, 2001Assignee: Metro Machine CorporationInventors: Richard A. Goldbach, James A. McMichael, Charles A. Garland
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Patent number: 6113075Abstract: A powered apparatus for removing floor coverings includes two frames which are interconnected in a scissor-type manner. Each of the frames supports one or more wheels which are secured at the outer ends of the frames. Thus, the wheels are adapted to be brought into contact in a vertical configuration. Furthermore, at least one of the wheels is driven. Also disclosed is a method of using the device of the present invention.Type: GrantFiled: September 16, 1999Date of Patent: September 5, 2000Inventors: Thomas James McMichael, Timothy Leon Hurlburt
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Patent number: 6102157Abstract: Each of a plurality of cargo holds of a bulk carrier vessel has a self-contained staging system lowered into it, from the platform track of which workers operate semi-automatic blasting machines that are mounted onto the platform. The set-up for each vessel also includes, for each hold, a ventilation unit provided on a hatch plug, and a transporter for the staging system. Groups of staging systems are served by on-deck air compressors. Staging systems actually engaging in blasting are served by recycling shot blast units which recycle and supply steel shot. Following blast cleaning, the cleaned surfaces are painted from the platforms.Type: GrantFiled: July 19, 1999Date of Patent: August 15, 2000Assignee: Metro Machine CorporationInventors: Richard A. Goldbach, James A. McMichael, Charles A. Garland
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Patent number: 5972351Abstract: A method of identifying peptides of an antigen of interest which are capable of recognition by or induction of cytotoxic T lymphocytes, comprises the steps of: ascertaining a "motif" of peptides which bind to a chosen HLA class I allele; providing peptides having this motif which are present in the known sequence of the antigen of interest; screening the peptides using an HLA assembly assay; and screening the resulting peptides for recognition by or induction of cytotoxic T lymphocytes. The above peptides have been identified by this method, and the peptides and vaccines containing them are also claimed.Type: GrantFiled: December 5, 1994Date of Patent: October 26, 1999Assignee: Isis Innovation LimitedInventors: Adrian Vivian Sinton Hill, Frances Margaret Gotch, John Elvin, Andrew James McMichael, Hilton Carter Whittle
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Patent number: 5700469Abstract: The present invention provides peptidal fragments of human immunodeficiency virus (HIV) which interact specifically with a particular human leucocyte antigen (HLA) class I molecule to stimulate cytotoxic T lymphocyte immunity.Type: GrantFiled: June 7, 1995Date of Patent: December 23, 1997Assignee: Medical Research CouncilInventors: Andre James McMichael, Douglas Fraser Nixon, Alain Robert Michael Townsend, Frances Margaret Gotch
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Patent number: 5700635Abstract: A novel human immunodeficiency virus type 1 (HIV-1) cytotoxic T-lymphocyte (CTL) epitope has been identified in the gag coding region. This epitope corresponds to amino acids 255-269 of Gag and has the following sequence: NH.sub.2 -asn-pro-pro-ile-pro-val-gly-glu-ile-tyr-lys-arg-trp-ile-ile-COOH. This peptide interacts specifically with human leukocyte antigen-B8 (HLA-B8). This peptide is useful for the identification HIV-1 gag-specific CTL.Type: GrantFiled: December 19, 1994Date of Patent: December 23, 1997Assignee: United Biomedical, Inc.Inventors: Andrew James McMichael, Douglas Fraser Nixon, Alain Robert Michael Townsend
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Patent number: 5683701Abstract: Peptides are described which have the amino acid sequence of a fragment of HIV (human immunodeficiency virus) which interacts specifically with a particular human leucocyte antigen (HLA) class I molecule, to stimulate cytotoxic T lymphocyte immunity. Such fragments can be used in a potential vaccine against AIDS (acquired immune deficiency syndrome), and for diagnostic and therapeutic purposes.Type: GrantFiled: December 9, 1994Date of Patent: November 4, 1997Assignee: United Biomedical, Inc.Inventors: Andrew James McMichael, Douglas Fraser Nixon, Alain Robert Michael Townsend
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Patent number: 5211125Abstract: For cleaning and/or painting the exterior of a ship hull while the ship is in dry dock, one or more staging devices are provided. Each includes a metal framework tower supporting a vertically movable elevator assembly that comprises a trolley, from which a variably laterally projecting platform is supported on articulated, cantilevered arms. Adjustable, non-porous shrouds enclose a volume of space between the outside of the tower and an increment of one side of the exterior of the ship hull, from above, fore, aft and outside. Cleaning and painting operations are conducted from the platform on the hull increment, and debris is removed from the dry-dock deck area enclosed by the shroud, after which the device is moved by crane, typically twenty feet (6.1 m), towards the ship's bow or stern. The shrouds are then adjusted so that a further hull increment can be worked on. The trolley and extension-retraction of the platform support arms are operated by electrohydraulic winch and hydraulic cylinders, respectively.Type: GrantFiled: October 24, 1991Date of Patent: May 18, 1993Assignees: Metro Machine Corporation, Tidewater Equipment CorporationInventors: Charles Garland, Richard A. Goldbach, Frank E. McConnell, James A. McMichael, William A. Wagner