Abstract: A multi-module wearable device. According to an embodiment of the present disclosure, there is provided a system, including: a first wearable instrument; a second wearable instrument including a biometric sensor; an electrical connection between the first wearable instrument and the second wearable instrument; and a strap, sized and dimensioned to be disposed about a wrist. The electrical connection may be capable of connecting the first wearable instrument to the second wearable instrument when the second wearable instrument is at a first position on the strap relative to the first wearable instrument, and of connecting the first wearable instrument to the second wearable instrument when the second wearable instrument is at a second position on the strap relative to the first wearable instrument.

Abstract: A system for sensing one or more biometrics. In some embodiments, the system includes a first wearable instrument; a second wearable instrument including a biometric sensor; a conductive connection between the first wearable instrument and the second wearable instrument; and a strap, sized and dimensioned to be disposed about a wrist. The system may be capable of securing the first wearable instrument to the strap, of securing the second wearable instrument to the strap at a first position relative to the first wearable instrument, and of securing the second wearable instrument to the strap at a second position relative to the first wearable instrument.

Abstract: This invention relates to crystals of the human Gremlin-1 protein, and the human Gremlin-1 protein in complex with an inhibitory antibody. The invention also relates to the structure of human Gremlin-1 (on its own, or in complex with the antibody) and uses of these structures in screening for agents which modulate Gremlin-1 activity. The invention further provides antibodies which bind an allosteric inhibitory site on Gremlin-1, together with pharmaceutical compositions and medical uses of such antibodies and agents identified by the screening methods.

Abstract: The present invention relates to Tau-binding antibodies and binding fragments thereof.

Abstract: Systems for forming composite parts, methods of forming composite parts, and methods of precisely performing a plurality of operations on a composite part. The systems include a layup mandrel that includes a mandrel body and a plurality of regions of isotropic surface finish. The methods of forming the composite part include positioning a plurality of plies of composite material on a layup mandrel, conforming the plurality of plies of composite material to a layup surface shape of the layup mandrel, and curing the plurality of plies of composite material. The methods of precisely performing the plurality of operations on a composite part include detecting a corresponding imprinted feature of a plurality of imprinted features, aligning an operating assembly of an end effector relative to the corresponding imprinted feature, and performing a corresponding operation of the plurality of operations on the composite part.

Abstract: A system and method for calibrating speckle-based sensor. In some embodiments, the system includes a wearable device including: a laser, an array detector; and a processing circuit, the processing circuit being configured to: obtain a calibration of the array detector, using an incoherent light source; obtain a speckle image, using the laser; and calculate a corrected speckle-based measurement, the corrected speckle-based measurement being based on the speckle image and on the calibration.

Abstract: This invention relates to crystals of the human Gremlin-1 protein, and the human Gremlin-1 protein in complex with an inhibitory antibody. The invention also relates to the structure of human Gremlin-1 (on its own, or in complex with the antibody) and uses of these structures in screening for agents which modulate Gremlin-1 activity. The invention further provides antibodies which bind an allosteric inhibitory site on Gremlin-1, together with pharmaceutical compositions and medical uses of such antibodies and agents identified by the screening methods.

Abstract: The present invention relates to Tau-binding antibodies and binding fragments thereof.

Abstract: A system (10; 110; 210; 510) for identifying a pipe and/or associated component parts of a piping system, comprises a vibration generation arrangement (12, 112, 212, 312, 512) configured for engagement with, for coupling to and/or operatively associated with a first pipe section (P1) and a vibration detection arrangement (14; 514) configured for engagement with, for coupling to and/or operatively associated with a second pipe section (P2; P3; P4). The vibration generation arrangement (12, 112, 212, 312, 512) is configured to generate a vibration in the first pipe section (P1), which forms an identification signal propagating along the pipe. The vibration detection arrangement (14; 514) is configured to detect vibration in the second pipe section (P2; P3; P4) and thus identify whether the second pipe section (P2; P3; P4) and the first pipe section (P1) form part of the same pipe or pipe assembly.

Abstract: A method of identifying of amino-acid residues on a target protein that form a binding site of a molecule of interest. Such method relies on selection of relevant patches of solvent-accessible residues and testing of an array of mutated proteins for changes of binding properties. Such method is useful for determining binding sites (epitopes) of antibodies, ligands and related molecules.

Abstract: An optical sensor module for measuring both speckleplethysmography (SPG) and photoplethysmography (PPG) signals at human or animal tissue, the optical sensor module comprising:a first light source, for illuminating the tissue for use with SPG measurements, the first light source comprising a laser; a second light source, for illuminating the tissue for use with PPG measurements; and one or more optical sensor(s) for receiving light from the illuminated tissue.

Abstract: An optical sensor module for measuring both speckleplethysmography (SPG) and photoplethysmography (PPG) signals at human or animal tissue, the optical sensor module comprising: a first light source, for illuminating the tissue for use with SPG measurements, the first light source comprising a laser; a second light source, for illuminating the tissue for use with PPG measurements; and one or more optical sensor(s) for receiving light from the illuminated tissue.

Abstract: The present invention relates to antibodies which bind and inhibit KLK5 and methods of using the same to treat diseases caused by KLK5 imbalance. In particular, the present invention relates to inhibitory antibodies binding KLK5 and their use in the treatment of Netherton disease, atopic dermatitis and cancer.

Abstract: The present invention relates to antibodies which bind and inhibit KLK5 and methods of using the same to treat diseases caused by KLK5 imbalance. In particular, the present invention relates to inhibitory anti-KLK5 antibodies and their use in the treatment of Netherton disease, atopic dermatitis and cancer.

Abstract: A bi-directional perfusion cannula is provided that includes an elongate tube for insertion into an artery. The elongate tube has a first aperture at a distal end of the tube which is forward during insertion and configured so that blood can flow into the artery in the direction of insertion, an elbow formed in the elongate tube, and a second aperture formed in or slightly rearward of the elbow and configured for supplying blood into the artery in a second direction which is generally opposite to the insertion direction.

Abstract: A moisture control apparatus for a cooking chamber of a cooking device. A cooking system that can include the cooking device and the moisture control apparatus connected to the cooking chamber of the cooking device. The moisture control apparatus can include a control portion and a dispersal portion. The control portion can be located on the outside of the cooking device. The control portion can control the flow of water to the dispersal portion so as to control moisture on a food in the cooking chamber of the cooking device by providing, by the dispersal portion, a mist or fog of water particles to the cooking surface of the cooking chamber. The dispersal portion can be located inside the cooking chamber of the cooking device, and the control portion can be located outside the cooking chamber of the cooking device.

Abstract: The present invention relates to alpha synuclein binding antibodies and fragments thereof capable of binding alpha synuclein as a monomer and in fibrils and preventing alpha synuclein aggregation induced by alpha synuclein fibrils. The antibodies of the present invention are for use in the treatment of alpha synucleinopathies, including Parkinson's disease.

Abstract: A bi-directional perfusion cannula is provided that includes an elongate tube for insertion into an artery. The elongate tube has a first aperture at a distal end of the tube which is forward during insertion and configured so that blood can flow into the artery in the direction of insertion, an elbow formed in the elongate tube, and a second aperture formed in or slightly rearward of the elbow and configured for supplying blood into the artery in a second direction which is generally opposite to the insertion direction.

Abstract: The present invention relates to antibodies binding alpha synuclein and fragments thereof capable of binding alpha synuclein as a monomer and in fibrils and preventing alpha synuclein aggregation induced by alpha synuclein fibrils. The antibodies of the present invention are for use in the treatment of alpha synucleinopathies, including Parkinson's disease.

Abstract: The present invention relates to alpha synuclein binding antibodies and fragments thereof capable of binding alpha synuclein as a monomer and in fibrils and preventing alpha synuclein aggregation induced by alpha synuclein fibrils. The antibodies of the present invention are for use in the treatment of alpha synucleinopathies, including Parkinson's disease.