Abstract: As disclosed herein, the present invention provides methods and systems for detecting, measuring, or monitoring the presence of absence of at least one emotion in a subject from a speech sample obtained from the subject. In particular, the methods and systems of the present invention comprise extracting at least one feature from the speech sample, assigning the speech sample a score using a weighted frequency band scoring scheme, and comparing the score with a general reference model or a control. As disclosed, the methods, systems and computer programs of the present invention provide detection error rates of about 4.7% or less, preferably about 3.0% or less, more preferably about 2.0% or less, most preferably about 1.0% or less and thereby reduced the detection error rate by about 60.0% or more, preferably about 70.0% or more, more preferably about 80.0% or more, even more preferably about 90% or more, and most preferably 95.0% or more than the detection error rates of prior art methods.

Abstract: The use of compounds belonging to the class of substituted pentanedioic acids to control aggressive behavior provides new means of treatment for this syndrome.

Abstract: Compounds of the general class of substituted pentanedioic acids, where the substituted moiety might be (subclass 1) a sulfanyl alkyl group; (subclass 2) an halogenated benzyl and a phosphinyl group; (subclass 3) a phosphonomethyl group, may be used for prevention, management and/or treatment of hyperaggressive behavior arising from environmental or social conditions, injury or disease, as may [2-(pentafluorophenylmethyl) hydroxyphosphinyl]methyl-pentanedioic acid, and/or other related substituted pentanedioic acids that inhibit NAALADase or mimic NAAG, and/or 2-(phosphonomethyl)-pentanedioic acid (2-PMPA) and/or beta-N-acetyl-aspartyl-glutamate (NAAG) and/or alpha N-acetyl-aspartyl-glutamate.

Abstract: The use of dihydrolipoic acid (DEL) and alpha-lipoic acid to treat and prevent damage to the retina arising from physical forces such as exposure to laser beams, and to compositions containing phenyl nitrones and DHL or alpha-lipoic acid as neuroprotective agents.