Patents by Inventor James Michael Chell

James Michael Chell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR DETERMINING A LOCATION OF A TARGET NUCLEIC ACID IN A BIOLOGICAL SAMPLE
    Publication number: 20250002982
    Abstract: The present disclosure relates to determining the location of analytes in fixed biological samples.
    Type: Application
    Filed: June 29, 2023
    Publication date: January 2, 2025
    Inventors: Marlon Stoeckius, James Michael Chell, Cedric Uytingco, Jennifer Chew, Felice Alessio Bava
  • SPATIAL DETECTION OF SARS-COV-2 USING TEMPLATED LIGATION
    Publication number: 20240368711
    Abstract: Provided herein are methods, compositions and kits for detecting SARS-CoV-2 and host nucleic acids in a tissue sample.
    Type: Application
    Filed: June 22, 2022
    Publication date: November 7, 2024
    Inventors: Stefania Giacomello, Hailey Elizabeth Sounart, Andrew John Hill, Erik Leonard Henrik Borgstrom, Aleksandra Jurek, James Michael Chell, Yuvarani Masarapu
  • METHODS FOR DETERMINING A LOCATION OF A TARGET NUCLEIC ACID IN A BIOLOGICAL SAMPLE
    Publication number: 20240271190
    Abstract: The present disclosure relates to determining the location of analytes in fixed biological samples.
    Type: Application
    Filed: February 6, 2023
    Publication date: August 15, 2024
    Inventors: Marlon Stoeckius, James Michael Chell, Cedric Uytingco, Jennifer Chew, Felice Alessio Bava
  • Methods for spatial analysis using RNA-templated ligation
    Patent number: 11981965
    Abstract: Provided herein are methods of detecting an analyte of interest to interrogate spatial gene expression in a sample using RNA-templated ligation.
    Type: Grant
    Filed: January 23, 2023
    Date of Patent: May 14, 2024
    Assignee: 10x Genomics, Inc.
    Inventors: James Michael Chell, Marlon Stoeckius, Jonathan Alles, Caroline Julie Gallant, Christina Galonska, Felice Alessio Bava, Layla Katiraee
  • METHODS FOR SPATIAL ANALYSIS USING RNA-TEMPLATED LIGATION
    Publication number: 20240124933
    Abstract: Provided herein are methods of detecting an analyte of interest to interrogate spatial gene expression in a sample using RNA-templated ligation.
    Type: Application
    Filed: October 9, 2023
    Publication date: April 18, 2024
    Inventors: James Michael Chell, Marlon Stoeckius, Jonathan Alles, Caroline Julie Gallant, Christina Galonska, Felice Alessio Bava, Layla Katiraee
  • SPATIALLY-TAGGED ANALYTE CAPTURE AGENTS FOR ANALYTE MULTIPLEXING
    Publication number: 20240053351
    Abstract: Provided herein are methods for preparing biological samples for spatial proteomic analysis, methods of determining a location of a protein analyte in a biological sample, and methods of determining a location of a protein analyte and a nucleic acid analyte in a biological sample.
    Type: Application
    Filed: October 3, 2023
    Publication date: February 15, 2024
    Inventors: Cedric Uytingco, James Michael Chell, Marlon Stoeckius, Albert Dale Kim, Dulce Ovando Morales, Andrej Hartnett, Yifeng Yin, Jennifer Chew
  • METHODS FOR SPATIAL ANALYSIS USING RNA-TEMPLATED LIGATION
    Publication number: 20230392204
    Abstract: Provided herein are methods of detecting an analyte of interest to interrogate spatial gene expression in a sample using RNA-templated ligation.
    Type: Application
    Filed: August 14, 2023
    Publication date: December 7, 2023
    Inventors: James Michael Chell, Marlon Stoeckius, Jonathan Alles, Caroline Julie Gallant, Christina Galonska, Layla Katiraee
  • Spatially-tagged analyte capture agents for analyte multiplexing
    Patent number: 11808769
    Abstract: Provided herein are methods for preparing biological samples for spatial proteomic analysis, methods of determining a location of a protein analyte in a biological sample, and methods of determining a location of a protein analyte and a nucleic acid analyte in a biological sample.
    Type: Grant
    Filed: January 26, 2023
    Date of Patent: November 7, 2023
    Assignee: 10x Genomics, Inc.
    Inventors: Cedric Uytingco, James Michael Chell, Marlon Stoeckius, Albert Dale Kim, Dulce Ovando Morales, Andrej Hartnett, Yifeng Yin, Jennifer Chew
  • Methods for spatial analysis using RNA-templated ligation
    Patent number: 11795507
    Abstract: Provided herein are methods of detecting an analyte of interest to interrogate spatial gene expression in a sample using RNA-templated ligation.
    Type: Grant
    Filed: August 26, 2022
    Date of Patent: October 24, 2023
    Assignee: 10x Genomics, Inc.
    Inventors: James Michael Chell, Marlon Stoeckius, Jonathan Alles, Caroline Julie Gallant, Christina Galonska, Layla Katiraee
  • DE-CROSSLINKING COMPOUNDS AND METHODS OF USE FOR SPATIAL ANALYSIS
    Publication number: 20230287475
    Abstract: Provided herein are methods for de-crosslinking fixed biological samples (e.g., fixed biological samples including aminal crosslinks). The compositions and methods disclosed can de-crosslink oligonucleotides (e.g., DNA or RNA) or proteins from fixed biological samples (e.g., fixed biological samples with aminal crosslinks), wherein the de-crosslinked biological sample is compatible with and can be used in spatial gene expression analysis.
    Type: Application
    Filed: December 22, 2020
    Publication date: September 14, 2023
    Inventors: James Michael Chell, Joshua Delaney, Rapolas Spalinskas, Aleksandra Jurek, Meiliana Tjandra
  • SPATIALLY-TAGGED ANALYTE CAPTURE AGENTS FOR ANALYTE MULTIPLEXING
    Publication number: 20230228762
    Abstract: Provided herein are methods for preparing biological samples for spatial proteomic analysis, methods of determining a location of a protein analyte in a biological sample, and methods of determining a location of a protein analyte and a nucleic acid analyte in a biological sample.
    Type: Application
    Filed: January 26, 2023
    Publication date: July 20, 2023
    Inventors: Cedric Uytingco, James Michael Chell, Marlon Stoeckius, Albert Dale Kim, Dulce Ovando Morales, Andrej Hartnett, Yifeng Yin, Jennifer Chew
  • PROFILING OF BIOLOGICAL ANALYTES WITH SPATIALLY BARCODED OLIGONUCLEOTIDE ARRAYS
    Publication number: 20230159995
    Abstract: This disclosure relates to methods for spatial profiling of analytes present in a biological sample. Also provided are methods for using spatially barcoded substrates to detect a biological analyte in a cell culture, an organism, and organoid. Also provided are methods for using spatially barcoded substrates to detect the temporal profile of a biological analyte.
    Type: Application
    Filed: July 20, 2022
    Publication date: May 25, 2023
    Inventors: Eswar Prasad Ramachandran Iyer, Tarjei Sigurd Mikkelsen, Augusto Manuel Tentori, Rajiv Bharadwaj, Marlon Stoeckius, James Michael Chell, Cedric Uytingco
  • METHODS FOR SPATIAL ANALYSIS USING RNA-TEMPLATED LIGATION
    Publication number: 20230160008
    Abstract: Provided herein are methods of detecting an analyte of interest to interrogate spatial gene expression in a sample using RNA-templated ligation.
    Type: Application
    Filed: January 23, 2023
    Publication date: May 25, 2023
    Inventors: James Michael Chell, Marlon Stoeckius, Jonathan Alles, Caroline Julie Gallant, Christina Galonska, Felice Alessio Bava, Layla Katiraee
  • PROFILING OF BIOLOGICAL ANALYTES WITH SPATIALLY BARCODED OLIGONUCLEOTIDE ARRAYS
    Publication number: 20230143569
    Abstract: This disclosure relates to methods for spatial profiling of analytes present in a biological sample. Also provided are methods for using spatially barcoded substrates to detect a biological analyte in a cell culture, an organism, and organoid. Also provided are methods for using spatially barcoded substrates to detect the temporal profile of a biological analyte.
    Type: Application
    Filed: July 20, 2022
    Publication date: May 11, 2023
    Inventors: Eswar Prasad Ramachandran Iyer, Tarjei Sigurd Mikkelsen, Augusto Manuel Tentori, Rajiv Bharadwaj, Marlon Stoeckius, James Michael Chell, Cedric Uytingco
  • METHODS AND KITS FOR IDENTIFYING, DIAGNOSING AND TREATING PROSTATE CARCINOMAS
    Publication number: 20230097123
    Abstract: The present disclosure generally relates to methods, systems and compositions for determining the presence or absence of prostate cancer in a subject, treating prostate cancer in a subject, and monitoring the efficacy of a treatment regimen for prostate cancer in a subject. The methods of the present disclosure comprise determining the expression levels and spatial locations of two or more analytes in a sample from a subject and correlating the expression levels and spatial locations to a prostate sample from a subject, thereby determining the presence or absence of prostate cancer, determining a treatment regimen for prostate cancer, or monitoring the efficacy of an existing treatment regimen in a subject undergoing treatment for prostate cancer.
    Type: Application
    Filed: September 29, 2022
    Publication date: March 30, 2023
    Applicant: 10x Genomics, Inc.
    Inventors: Valeria GIANGARRA, James Michael CHELL, Stephen R. WILLIAMS, Mesruh TURKEKAL, Paulius MIELINIS, Caroline Julie GALLANT, Sarah E. B. TAYLOR, Aleksandra JUREK
  • METHODS FOR SPATIAL ANALYSIS USING RNA-TEMPLATED LIGATION
    Publication number: 20230064372
    Abstract: Provided herein are methods of detecting an analyte of interest to interrogate spatial gene expression in a sample using RNA-templated ligation.
    Type: Application
    Filed: August 26, 2022
    Publication date: March 2, 2023
    Inventors: James Michael Chell, Marlon Stoeckius, Jonathan Alles, Caroline Julie Gallant, Christina Galonska, Layla Katiraee
  • Spatially-tagged analyte capture agents for analyte multiplexing
    Patent number: 11592447
    Abstract: Provided herein are methods for preparing biological samples for spatial proteomic analysis, methods of determining a location of a protein analyte in a biological sample, and methods of determining a location of a protein analyte and a nucleic acid analyte in a biological sample.
    Type: Grant
    Filed: May 6, 2022
    Date of Patent: February 28, 2023
    Assignee: 10x Genomics, Inc.
    Inventors: Cedric Uytingco, James Michael Chell, Marlon Stoeckius, Albert Kim, Dulce Ovando Morales, Andrej Hartnett, Yifeng Yin, Jennifer Chew
  • Methods for spatial analysis using RNA-templated ligation
    Patent number: 11560593
    Abstract: Provided herein are methods of detecting an analyte of interest to interrogate spatial gene expression in a sample using RNA-templated ligation.
    Type: Grant
    Filed: March 29, 2022
    Date of Patent: January 24, 2023
    Assignee: 10x Genomics, Inc.
    Inventors: James Michael Chell, Marlon Stoeckius, Jonathan Alles, Caroline Julie Gallant, Christina Galonska, Felice Alessio Bava, Layla Katiraee
  • DE-CROSSLINKING COMPOUNDS AND METHODS OF USE FOR SPATIAL ANALYSIS
    Publication number: 20220404245
    Abstract: Provided herein are methods for de-crosslinking fixed biological samples (e.g., fixed biological samples including aminal crosslinks). The compositions and methods disclosed can de-crosslink oligonucleotides (e.g., DNA or RNA) or proteins from fixed biological samples (e.g., fixed biological samples with aminal crosslinks), wherein the de-crosslinked biological sample is compatible with and can be used in spatial gene expression analysis.
    Type: Application
    Filed: August 16, 2022
    Publication date: December 22, 2022
    Inventors: James Michael Chell, Joshua Delaney, Rapolas Spalinskas, Aleksandra Jurek, Meiliana Tjandra
  • Methods for spatial analysis using RNA-templated ligation
    Patent number: 11505828
    Abstract: Provided herein are methods of detecting an analyte of interest to interrogate spatial gene expression in a sample using RNA-templated ligation.
    Type: Grant
    Filed: April 1, 2021
    Date of Patent: November 22, 2022
    Assignee: 10x Genomics, Inc.
    Inventors: James Michael Chell, Marlon Stoeckius, Jonathan Alles, Caroline Julie Gallant, Christina Galonska, Layla Katiraee