Abstract: The present disclosure provides a prefilled wrap, such as a prefilled poultice wrap, for applying to the body of a human or animal. The prefilled wrap includes a matrix defining a plurality of pockets therein. The prefilled wrap also includes a dry ingredient formulation contained in each of the plurality of pockets. The present disclosure also provides a prefilled wrap system for applying to the body of a human or animal. The prefilled wrap system includes an outer casing configured to wrap around a portion of the body of the human or animal. The prefilled wrap system also includes a prefilled wrap removably received in the outer casing. The outer casing is configured to hold the prefilled wrap against the body of the human or animal. Related methods of manufacturing the prefilled wrap, applying the prefilled wrap, and applying the prefilled wrap system are also disclosed.