Abstract: A seating arrangement includes a support shell including a seat portion and a chair back portion each configured to support a seated user, the chair seat portion having a front region and a rear region and the chair back portion having an upper region and a lower region, where the rear region of the seat portion is coupled to the lower region of the chair back portion, a control member including a substantially flexible front support and an attachment point, where the front support engages the support shell in the front region of the seat portion and the control member engages the back portion, and a substantially rigid second support attached to the control member at the attachment point, wherein the control member is an integral, one-piece component including multiple flex regions configured to allow the support shell to move between an upright and reclined position.

Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: The specification relates to spirocyclic compounds of Formula (I) and pharmaceutically acceptable salts thereof. The specification also relates to processes and intermediates used for their preparation, pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders.

Abstract: The specification relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof. The specification also relates to processes and intermediates used for their preparation, pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders.

Abstract: The invention concerns compounds of Formula (I): or pharmaceutically acceptable salts thereof, wherein R1, R2, R3 and R4 have any of the meanings hereinbefore defined in the description; process for their preparation, pharmaceutical compositions containing them and their use in treating KIT mediated diseases.

Abstract: The invention concerns compounds of Formula (I): or pharmaceutically acceptable salts thereof, wherein R1, R2, R3 and R4 have any of the meanings hereinbefore defined in the description; process for their preparation, pharmaceutical compositions containing them and their use in treating KIT mediated diseases.

Abstract: The specification relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof. The specification also relates to processes and intermediates used for their preparation, pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders.

Abstract: The specification relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof. The specification also relates to processes and intermediates used for their preparation, pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders.

Abstract: A water filter cartridge (10) has a two-piece housing (14, 18) internally configured with inlet and outlet openings (12, 16), a diffuser (42), and a plurality of diverter plates (56, 32) to optimize liquid flow and to regulate even flow through a charcoal filter medium (40) located inside of the housing.

Abstract: A water filter cartridge (10) has a two-piece housing (14, 18) internally configured with inlet and outlet openings (12, 16), a diffuser (42), and a plurality of diverter plates (56, 32) to optimize liquid flow and to regulate even flow through a charcoal filter medium (40) located inside of the housing.

Abstract: A blank, or tray, comprising of bottom panel having side walls foldably connected to opposite sides thereof via a pair of substantially parallel side fold lines, end wall forming panels, each of the end wall forming panels being defined in the bottom panel and side walls by a line of weakness extending across said bottom wall and part way into each of said side walls, a first pair of fold line extending one from each end of said line of weakness toward a junction formed with a projection of the adjacent said side fold line and a second pair of fold lines extending one from said line of weakness toward each of said junctions to form in each of said end wall forming panels an end wall and a pair of connecting side walls said first and second pairs of fold lines each being symmetrically positioned on opposite sides of the longitudinal center line of the blank a reinforcing panel connected to each of said side walls one of said reinforcing panels having a flap foldably connected to its free edge and the other of