Abstract: Closures with a tamper evidence feature that is reshaped to connect it to the container neck are disclosed. Methods and systems for carrying out the methods, and to mold stacks for making the closures are also disclosed. The tamper evidence feature can be a band, a portion of a cylindrical skirt or a panel formed in the cylindrical skirt.

Abstract: Disclosed are compounds of general formula (I): and pharmaceutically acceptable salts thereof, formulations, methods and uses in, for example, the treatment of disease.

Abstract: Closures with a tamper evidence feature that is reshaped to connect it to the container neck are disclosed. Methods and systems for carrying out the methods, and to mold stacks for making the closures are also disclosed. The tamper evidence feature can be a band, a portion of a cylindrical skirt or a panel formed in the cylindrical skirt.

Abstract: Antibody-drug conjugates (ADCs) comprising an antibody construct that binds specifically binds human folate receptor alpha (FR?) (an anti-FR? antibody construct) conjugated to a camptothecin analogue of Formula (I). The ADCs are useful as therapeutics, in particular in the treatment of cancer.

Abstract: Closures with a tamper evidence feature that is reshaped to connect it to the container neck are disclosed. Methods and systems for carrying out the methods, and to mold stacks for making the closures are also disclosed. The tamper evidence feature can be a band, a portion of a cylindrical skirt or a panel formed in the cylindrical skirt.

Abstract: Disclosed are compounds of general formula (I): and pharmaceutically acceptable salts thereof, formulations, methods and uses in, for example, the treatment of disease.

Abstract: Camptothecin analogues of Formula (I) and conjugates comprising the camptothecin analogues are described. The camptothecin analogues and conjugates may be used as therapeutic agents, particularly in the treatment of cancer, an autoimmune disease or a viral infection.

Abstract: In image processing system comprises an input configured to receive an image signal, the image signal including a plurality of frames of image data; and a processor configured to automatically determine an image classification based on at least one frame of the plurality of frames, and dynamically generate a mapping metadata based on the image classification. The processor includes determination circuitry configured to determine a content type for the image signal; segmentation circuitry configured to segment the image data into a plurality of feature item regions, based on the content type; extraction circuitry configured to extract at least one image aspect value for respective ones of the plurality of feature item regions.

Abstract: Described are methods of preparing reduced 3,7-diamino-10H-phenothiazine (DAPTZ) compounds of formula: wherein: R1 and R9 are independently selected from: —H; C1-4alkyl; C2-4 alkenyl; and halogenated C1-4 alkyl; each of R3NA and R3NB is independently selected from: —H; C1-4 alkyl; C2-4 alkenyl; and halogenated C1-4 alkyl; each of R7NA and R7NB is independently selected from: —H; C1-4 alkyl; C2-4 alkenyl; and halogenated C1-4 alkyl; each of HX1 and HX2 is independently a protic acid; and pharmaceutically acceptable salts, solvates, and hydrates thereof. These methods are particularly useful for producing stable reduced forms, and with high purity. The stability and purity are especially relevant for pharmaceutical compositions for the treatment of disease. The compounds are useful for treatment of e.g. tauopathies, such as Alzheimer's disease, and also as prodrugs for the corresponding oxidized thioninium drugs.

Abstract: Compounds of formula (I): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.

Abstract: Disclosed herein is an airfoil beach shade system. The system is comprised of a rectangular, beach shade constructed of multiple airfoils. The beach shade is attached on one side to a pivoting T-frame while the opposite side remains unattached or unfixed. The wind fills the airfoils, causing the beach shade to elevate and stay elevated while providing shade underneath. The pivoting T-frame allows for the device to automatically adjust to the changing direction of the wind.

Abstract: In one embodiment, an environmental sensor array monitors pre-filter airflow to a fuel cell with an air filter, and senses amounts of filter exposure of air contaminants in the monitored pre-filter airflow. The environmental sensor array may then correlate the sensed amounts of filter exposure over time to a long-term adsorption limit of the air contaminants for the air filter, determining a lifetime usage level of the air filter. Accordingly, the environmental sensor array may provide an indication of the lifetime usage level of the air filter. In another embodiment, the environmental sensor array may also monitor post-filter airflow to the fuel cell, and senses instantaneous levels of post-filter air contaminants. In response to the instantaneous level of any particular air contaminant of the post-filter air contaminants being above a respective threshold level, the environmental sensor array may protect the operation of the fuel cell (e.g., de-rate, shut down, etc.).

Abstract: Novel techniques for pooling the available transmit power of a beam across the subcarriers that are or that are scheduled to be in use (and not across all available subcarriers) are disclosed. The scheduled subcarriers may be located in the same or different carriers of a modulation transmitter modulation system, and the pooled transmit power may be allocated or distributed across the scheduled subcarriers of the beam. Modulation symbols or resource elements may be transmitted in accordance with allocated, per-subcarrier power budgets, thereby maximizing the SNIR of signals that are transmitted in the beam via the scheduled subcarriers. Additionally, the allocation of the pooled transmit power to various subcarriers may continuously and/or dynamically vary over time, e.g., based on traffic demands, interference characteristics, etc., as well as based on subsequent scheduling of subcarriers to transmit subsequent modulation symbols or resource elements.

Abstract: Apparatus and method for improving the detection of signals obscured by noise using stochastic resonance noise. The method determines the stochastic resonance noise probability density function in non-linear processing applications that is added to the observed data for optimal detection with no increase in probability of false alarm. The present invention has radar, sonar, signal processing (audio, image and video), communications, geophysical, environmental, and biomedical applications.

Abstract: Apparatus and method for improving the detection of signals obscured by noise using stochastic resonance noise. The method determines the stochastic resonance noise probability density function in non-linear processing applications that is added to the observed data for optimal detection with no increase in probability of false alarm. The present invention has radar, sonar, signal processing (audio, image and video), communications, geophysical, environmental, and biomedical applications.

Abstract: During operation, nodes that receive beacons from a different network will synchronize to the different network when a predetermined condition is met. Synchronization to the differing network will only take place if the node receiving the beacon from a different network does not have access to a fixed network coordinator and the predetermined condition is met. The predetermined condition may comprise such things as a Network ID for the different network being larger than the Network ID for the current network, or alternatively, the size of the different network being larger than a size of the current network.

Abstract: A method and apparatus for synchronizing a node (200) within an ad-hoc communication system (100) is described herein. During operation all nodes periodically broadcast a synchronization beacon for other nodes to utilize for synchronization when a coordinating access point (node) is unavailable. A particular node's synchronization beacon will have an associated “tier” number that is incremented from the tier number of the beacon used to synchronize the particular node. In the absence of an access point, a node that joins the ad-hoc communication system will listen for synchronization beacons transmitted by other nodes. If synchronization beacons are heard, the node will synchronize with a beacon having a lowest tier. The node will then broadcast its own beacon having its tier number incremented from the lowest tier beacon heard.

Abstract: A fertilizer spreader includes an attachment assembly for use with a portable hand-held air blower for entraining granular fertilizer or the like into the discharge air stream of the blower, whereby the fertilizer is broadcast by the air stream over a lawn or garden area. The attachment assembly comprises an adapter nozzle connected in-line with the discharge air stream of the blower and including a pressure port through which a portion of the discharge air stream is directed for passage through a pressure tube to a diffuser mounted within a portable vented fertilizer-receiving container near the bottom thereof. The diffuser turns the air stream upwardly within the container and divides the stream into a plurality of turbulent air flows for agitating and suspending particles in a localized region above the diffuser, with a substantial portion of the air stream escaping from the container through a vent at a position remote from the localized region.

Abstract: A fertilizer spreader includes an attachment assembly for use with a portable hand-held air blower for entraining granular fertilizer or the like into the discharge air stream of the blower, whereby the fertilizer is broadcast by the air stream over a lawn or garden area. The attachment assembly comprises an adapter nozzle connected in-line with the discharge air stream of the blower and including a pressure port through which a portion of the discharge air stream is directed for passage through a pressure tube to a diffuser mounted within a portable fertilizer-receiving container near the bottom thereof. The diffuser turns the air stream upwardly within the container and divides the stream into a plurality of turbulent air flows for agitating and suspending particles in a localized region above the diffuser.