Abstract: The present invention is an automated microfluidic chip processing apparatus that includes a deck for holding at least one microfluidic chip and capable of being accessed by a liquid handling system, a fluid control system, and a detection system, wherein a chip handling device transports the chip from the deck to the fluid control system and the detection system. The present invention also includes a chip for use with an automated microfluidic chip processing apparatus, and a method for processing a microfluidic chip using such an apparatus.

Abstract: Apparatus and methods according to the present invention utilize micropumps that are capable of generating high pressure and flow without moving mechanical parts and the associated generation of unacceptable electrical and acoustic noise, as well as the associated reduction in reliability. These micropumps are fabricated with materials and structures that improve performance, efficiency, and reduce weight and manufacturing cost relative to presently available micropumps. These micropumps also can allow for recapture of evolved gases and deposited materials, which may provide for long-term closed-loop operation. Apparatus and methods according to the present invention also allow active regulation of the temperature of the device through electrical control of the flow through the pump and can utilize multiple cooling loops to allow independent regulation of the spatial and temporal characteristics of the device temperature profiles. Novel enclosed microchannel structures are also described.

Abstract: Apparatus and methods according to the present invention preferably utilize electroosmotic pumps that are capable of generating high pressure and flow without moving mechanical parts and the associated generation of unacceptable electrical and acoustic noise, as well as the associated reduction in reliability. These electroosmotic pumps are preferably fabricated with materials and structures that improve performance, efficiency, and reduce weight and manufacturing cost relative to presently available micropumps. These electroosmotic pumps also preferably allow for recapture of evolved gases and deposited materials, which may provide for long,-term closed-loop operation. Apparatus and methods according to the present invention also allow active regulation of the temperature of the device through electrical control of the flow through the pump and can utilize multiple cooling loops to allow independent regulation of the special and temporal characteristics of the device temperature profiles.

Abstract: An apparatus for use with a patient having a vessel carrying blood to ascertain characteristics of the blood. The apparatus includes a display module and a probe having a distal extremity adapted to be inserted into the vessel of the patient and having a proximal extremity coupled to the display module. The probe includes a sensor in the distal extremity for providing an electrical signal to the display module when the probe is disposed in the blood. The probe can have an antithrombogenic surface treatment for inhibiting the adhesion of blood components to the probe when disposed in the blood.

Abstract: A method of characterizing a polypeptide, comprising providing a first capillary channel having a separation buffer disposed within, wherein the separation buffer comprises a non-crosslinked polymer solution, a buffering agent, a detergent, and a lipophilic dye. The separation buffer is provided such that, at the time of detection, the detergent concentration in the buffer is not above the critical micelle concentration. The polypeptide is introduced into one end of the capillary channel. An electric field is applied across a length of the capillary channel, which transports polypeptides of different sizes through the polymer solution at different rates. The polypeptide is then detected as it passes a point along the length of the capillary channel.

Abstract: A display media with an encapsulant medium, and bichromal beads having a crystalline material, wherein the bichromal beads are dispersed or contained in the encapsulant medium is set forth.

Abstract: An external field activated display sheet is disclosed which comprises a plurality of hourglass shaped capsules for each pixel of an image. Each hourglass shaped capsule contains ink in one of its chambers. The ink in each hourglass shaped capsule is responsive to an external field being applied across the capsule for the movement from one chamber to the other. An opaque medial sheet blocks the visibility of the ink in the chambers under the medial sheet. Applying an external field across an hourglass shaped capsule causes the ink to be moved into the chamber above the medial sheet where it is visible. By applying an external field across selective hourglass shaped cavities, an image can be displayed.

Abstract: Sweep tillage tools (10, 10') according to the preferred teachings of the present invention are disclosed including generally flat, horizontal sweep blades (18) generally located behind the implement shank (12) and above the point (28) of the spike (16, 16'). Specifically, the front corners of the sweep blades (18) between their front cutting edges (36) and inside edges (40) are integrally connected to the side edges (34) of a central portion (32, 32'). Gussets (20) are provided having a first side (48) integrally connected generally perpendicular to the inside edges (40) of the sweep blades (18) and having a second side (50) integrally connected to the side edges (34) of the central portion (32, 32') to provide catilever mounting of the sweep blades (18) and to provide support for soil passing over the spike (16, 16') and the sweep blades (18) at their intersection.

Abstract: A sweep-spike combination tillage tool (10) according to the preferred teachings of the present invention is disclosed including generally flat, horizontal sweep blades (18) located behind a spike (16) and above the point (28) of the spike (16). Specifically, the front corners of the sweep blades (18) between their front cutting edges (36) and inside edges (40) are integrally connected to the side edges (34) of the spike (16). Gussets (20) are provided having a first side (48) integrally connected generally perpendicular to the inside edges (40) of the sweep blades (18) and having a second side (50) integrally connected generally tangentially to the side edges (34) of the spike (16) to provide cantilever mounting of the sweep blades (18) and to provide support for soil passing over the spike (16) and the sweep blades (18) at their interconnection.