Abstract: Methods of treatment of pulmonary hypertension comprising dry powder inhalation administration of imatinib, a pharmaceutically acceptable salt, or a derivative thereof, are provided. Dry powder inhalable compositions comprising imatinib, a pharmaceutically acceptable salt, or a derivative thereof, are also provided as well as methods of making the same.

Abstract: A process of drug shortage prediction includes defining a classifier and loading a listing of drug shortage events at different times in association with different drugs. Over different periods of time, transactions between nodes of the pharmaceutical supply chain are read on a data bus of a digital supply network computing platform, each indicating a receipt of a particular drug by a particular dispensary. Drug shortage events are then correlated with ones of the transactions at a specified duration of time preceding the drug shortage events. Consequently, the classifier can be trained with the correlated transactions annotated as giving rise to the drug shortage events. Finally, the classifier receives queries with newly observed transactions on the data bus and, in response, a likelihood is determined that a drug shortage event for a specific one of the drugs will occur at the specified duration of time following the newly observed transactions.

Abstract: Methods of treatment of pulmonary hypertension comprising dry powder inhalation administration of imatinib, a pharmaceutically acceptable salt, or a derivative thereof, are provided. Dry powder inhalable compositions comprising imatinib, a pharmaceutically acceptable salt, or a derivative thereof, are also provided as well as methods of making the same.

Abstract: The locking system is provided for controlling the unlocking of a door by an electronic key. The locking system has a first pack configured to be received within a first recessed area of the door, the first pack having an actuator configured and adapted to move a bolt slidingly housed in the lock pack; a second pack configured to be received within a second recessed area of the door; a reader interface adapted to receive an input from the electronic key and a controller adapted to receive the input from the reader interface, authenticate the input, and control the actuator based on the authentication.

Abstract: The locking system is provided for controlling the unlocking of a door by an electronic key. The locking system has a first pack configured to be received within a first recessed area of the door, the first pack having an actuator configured and adapted to move a bolt slidingly housed in the lock pack; a second pack configured to be received within a second recessed area of the door; a reader interface adapted to receive an input from the electronic key and a controller adapted to receive the input from the reader interface, authenticate the input, and control the actuator based on the authentication.

Abstract: The locking system is provided for controlling the unlocking of a door by an electronic key. The locking system has a first pack configured to be received within a first recessed area of the door, the first pack having an actuator configured and adapted to move a bolt slidingly housed in the lock pack; a second pack configured to be received within a second recessed area of the door; a reader interface adapted to receive an input from the electronic key and a controller adapted to receive the input from the reader interface, authenticate the input, and control the actuator based on the authentication.

Abstract: The method can include the steps of: providing a local coordinator device having at least a first peripheral association data pertaining to the at least one peripheral device; seamlessly receiving the mobile credential from the at least one mobile device with the local coordinator device; validating the received mobile device credential; and subsequently to said validating, establishing the remote control association between the at least one mobile device and the at least one peripheral device using the first peripheral association data.

Abstract: The locking system is provided for controlling the unlocking of a door by an electronic key. The locking system has a first pack configured to be received within a first recessed area of the door, the first pack having an actuator configured and adapted to move a bolt slidingly housed in the lock pack; a second pack configured to be received within a second recessed area of the door; a reader interface adapted to receive an input from the electronic key and a controller adapted to receive the input from the reader interface, authenticate the input, and control the actuator based on the authentication.

Abstract: A method/apparatus/system for generating a recommendation based on user interactions with nodes and associated tasks within a prerequisite graph. The recommendation is generated by identifying the user's current position within the prerequisite graph and identifying potential next nodes to which the user could move. Based on the user's past interactions with nodes and/or tasks within the prerequisite graph, the user's likelihood of successfully completing the potential next node is calculated, and a recommendation is made based on this calculated likelihood of the user successfully completing the potential next node.

Abstract: The method can include the steps of: providing a local coordinator device having at least a first peripheral association data pertaining to the at least one peripheral device; seamlessly receiving the mobile credential from the at least one mobile device with the local coordinator device; validating the received mobile device credential; and subsequently to said validating, establishing the remote control association between the at least one mobile device and the at least one peripheral device using the first peripheral association data.

Abstract: A method/apparatus/system for generating a recommendation based on user interactions with nodes and associated tasks within a prerequisite graph. The recommendation is generated by identifying the user's current position within the prerequisite graph and identifying potential next nodes to which the user could move. Based on the user's past interactions with nodes and/or tasks within the prerequisite graph, the user's likelihood of successfully completing the potential next node is calculated, and a recommendation is made based on this calculated likelihood of the user successfully completing the potential next node.

Abstract: A method/apparatus/system for generating a recommendation based on user interactions with nodes and associated tasks within a prerequisite graph. The recommendation is generated by identifying the user's current position within the prerequisite graph and identifying potential next nodes to which the user could move. Based on the user's past interactions with nodes and/or tasks within the prerequisite graph, the user's likelihood of successfully completing the potential next node is calculated, and a recommendation is made based on this calculated likelihood of the user successfully completing the potential next node.

Abstract: A method/apparatus/system for generating a recommendation based on user interactions with nodes and associated tasks within a prerequisite graph. The recommendation is generated by identifying the user's current position within the prerequisite graph and identifying potential next nodes to which the user could move. Based on the user's past interactions with nodes and/or tasks within the prerequisite graph, the user's likelihood of successfully completing the potential next node is calculated, and a recommendation is made based on this calculated likelihood of the user successfully completing the potential next node.

Abstract: A flexible structure is provided that includes multiple members and a hinge set providing a connection between adjacent members. The hinge set includes at least one living hinge where multiple living hinges are separated by segment portions that collapse on each other when the hinge set is in a closed position.

Abstract: Methods for customizing an educational experience of a gamer are provided. The method can include the generating of learning DNA which can include information relating to the gamer. The learning DNA can be generated by the aggregation of data received from the gamer, collected from other data sources, and generated based on the interaction of the user with an evaluation and rectification system. The method can further include selecting a mission for a user based on the learning DNA and/or information relating to the user.

Abstract: A method/apparatus/system for generating a recommendation based on user interactions with nodes and associated tasks within a prerequisite graph. The recommendation is generated by identifying the user's current position within the prerequisite graph and identifying potential next nodes to which the user could move. Based on the user's past interactions with nodes and/or tasks within the prerequisite graph, the user's likelihood of successfully completing the potential next node is calculated, and a recommendation is made based on this calculated likelihood of the user successfully completing the potential next node.

Abstract: Methods for customizing an educational experience of a gamer are provided. The method can include the generating of learning DNA which can include information relating to the gamer. The learning DNA can be generated by the aggregation of data received from the gamer, collected from other data sources, and generated based on the interaction of the user with an evaluation and rectification system. The method can further include selecting a mission for a user based on the learning DNA and/or information relating to the user.

Abstract: Methods for customizing an educational experience of a gamer are provided. The method can include the generating of learning DNA which can include information relating to the gamer. The learning DNA can be generated by the aggregation of data received from the gamer, collected from other data sources, and generated based on the interaction of the user with an evaluation and rectification system. The method can further include selecting a mission for a user based on the learning DNA and/or information relating to the user.

Abstract: The invention is directed to materials and methods associated with polymorphic variants in two enzymes involved in folate-dependent and one-carbon metabolic pathways: MTHFD1 (5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase) and methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (MTHFD1L). Diagnostic and therapeutic methods are provided involving the correlation of polymorphic variants in MTHFD1, MTHFD1, and other genes with relative susceptibility for various pregnancy-related and other complications.

Abstract: The invention is directed to materials and methods associated with polymorphic variants in two enzymes involved in folate-dependent and one-carbon metabolic pathways: MTHFD1 (5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase) and methylenetetrahydrofolate dehydrogenase (NADP+dependent) 1-like (MTHFD1L). Diagnostic and therapeutic methods are provided involving the correlation of polymorphic variants in MTHFD1, MTHFD1, and other genes with relative susceptibility for various pregnancy-related and other complications.