Abstract: Breast density measurements are used to perform Breast Imaging Reporting and Data System (BI-RADS) classification during breast cancer screenings. The accuracy of breast density measurements can be improved by quantitatively processing digital mammographic images. For example, breast segmentation may be performed on a mammographic image to isolate the breast tissue from the background and pectoralis tissue, while a breast thickness adjustment may be performed to compensate for decreased tissue thickness near the skin line of the breast. In some instances, BI-RADS density categorization may consider the degree to which dense tissue is dispersed throughout the breast. A breast density dispersion parameter can also be obtained using quantitative techniques, thereby providing objective BI-RADS classifications that are less susceptible to human error.

Abstract: Systems, methods, and apparatuses for analyzing histopathology images to determine the presence of certain predetermined abnormalities. The system processes histopathology images to identify/highlight regions of interest (e.g., a region that may comprise parts of a tumor, cancerous cells, or other predetermined abnormality) for subsequent review by a pathologist or other trained professional. For example, the system may process histopathology images of H&E-stained lymph node tissue to identify potentially cancerous cells within the histopathology images.

Abstract: Breast density measurements are used to perform Breast Imaging Reporting and Data System (BI-RADS) classification during breast cancer screenings. The accuracy of breast density measurements can be improved by quantitatively processing digital mammographic images. For example, breast segmentation may be performed on a mammographic image to isolate the breast tissue from the background and pectoralis tissue, while a breast thickness adjustment may be performed to compensate for decreased tissue thickness near the skin line of the breast. In some instances, BI-RADS density categorization may consider the degree to which dense tissue is dispersed throughout the breast. A breast density dispersion parameter can also be obtained using quantitative techniques, thereby providing objective BI-RADS classifications that are less susceptible to human error.

Abstract: The present invention relates to a method and system for detecting biologically relevant structures in a hierarchical fashion, beginning at a low-resolution and proceeding to higher levels of resolution. The present invention also provides probabilistic pairwise Markov models (PPMMs) to classify these relevant structures. The invention is directed to a novel classification approach which weighs the importance of these structures. The present invention also provides a fast, efficient computer-aided detection/diagnosis (CAD) system capable of rapidly processing medical images (i.e. high throughput). The computer-aided detection/diagnosis (CAD) system of the present invention allows for rapid analysis of medical images the improving the ability to effectively detect, diagnose, and treat certain diseases.

Abstract: The present invention relates to a method and system for detecting biologically relevant structures in a hierarchical fashion, beginning at a low-resolution and proceeding to higher levels of resolution. The present invention also provides probabilistic pairwise Markov models (PPMMs) to classify these relevant structures. The invention is directed to a novel classification approach which weighs the importance of these structures. The present invention also provides a fast, efficient computer-aided detection/diagnosis (CAD) system capable of rapidly processing medical images (i.e. high throughput). The computer-aided detection/diagnosis (CAD) system of the present invention allows for rapid analysis of medical images the improving the ability to effectively detect, diagnose, and treat certain diseases.

Abstract: An improved Land Grid Array interconnect structure is provided with the use of small metal bumps on the substrate electrical contact pad. The bumps interlock with segments of the fuzz button connection and increase the physical contact surface area between the contact pad and fuss button. The improved contact reduces displacement of electrical contact points due to thermo-mechanical stress and lowers the required actuation force during assembly.

Abstract: The disclosure is directed to a method of manufacturing a booklet from a rectangular sheet of paper having information regarding a drug product printed thereon. The method comprises applying a first portion of glue to a first face of the sheet of paper along a single linear path, applying a second portion of glue to a second face of the sheet of paper along a single linear path, making a plurality of parallel folds in the sheet of paper in a direction transverse to the single linear paths along which the glue was applied to produce an intermediate item, and trimming the intermediate item in a direction parallel to the plurality of parallel folds to cause the first and second of the plurality of parallel folds to be removed from the intermediate item.

Abstract: An improved Land Grid Array interconnect structure is provided with the use of small metal bumps on the substrate electrical contact pad. The bumps interlock with segments of the fuzz button connection and increase the physical contact surface area between the contact pad and fuzz button. The improved contact reduces displacement of electrical contact points due to thermo-mechanical stress and lowers the required actuation force during assembly.

Abstract: A method for developing an integrated circuit chip design includes the steps of developing an architecture specification defining the functions of the chip, developing a microarchitecture specification based on the architecture specification, developing a functional and structural model of the chip based on the microarchitecture specification, designing software tools for use with the chip based on the architecture specification, and designing chip verification tools based on the microarchitecture specification. The activities associated with chip development are divided into phases which may be performed concurrently. The result of the development is an RTL model of the chip which can be utilized in implementation of products without comprising proprietary circuit, layout and fabrication process information of the entity that is implementing the products.