Abstract: The disclosure relates to microparticles and nanoparticles comprising a polymer matrix comprising an uncapped polymer and a net positively charged therapeutic agent at neutral pH. More particularly the disclosure relates to PLGA and/or PLA particles comprising an uncapped polymer for extended, controlled release of positively charged proteins or peptides at neutral pH. Methods of making the particles and administering the particles are also provided.

Abstract: The present invention relates to a high throughput targeted proteomics-based method for identifying and quantifying one or more binding molecules in a biological fluid of an individual. The present invention involves the use of a plurality of bait molecules to capture the binding molecules. The invention uses proteomics techniques, such as mass spectrometry, for the identification and quantification of the binding molecules. The methods of the invention can be used to identify and quantify antibodies produced by an individual, and proteins expressed by an individual, following exposure to antigens, such as viral antigens, particularly coronavirus antigens and more particularly SARS-CoV-2. Exposure may be via vaccination or following natural infection. The methods of the invention can be used to identify and quantify molecules which bind to a range of proteins of interest, such as autoantigens and neoantigens, as well as to viral vectors.

Abstract: An air purifying system having a series of specific filters stacked to facilitate removal of particles from the air. Removable filters include a pre-filter, a HEPA electrostatic filter, an activated carbon filter and a cold catalyst filter. Additional filters or alternate filters may be used, so long as there is no negative impact on the system efficiency and effectiveness.

Abstract: A mobile device used for controlling a plurality of air filtering units includes a display, at least one processor, and memory stored instructions that, when executed by the at least one processor, cause the mobile device to perform specific operations. The specific operations include displaying a graphical interface having icons which corresponds to either a preset operation or a control feature of the air filtering units, assigning each air filtering unit to a collection of air filtering units, navigating the graphical interface to input, by a user, a single set of appropriate operating parameters for the stored collection of units, and sending the operating parameters to each air filtering unit assigned to the collection via a wireless network.

Abstract: An air purifying system having two series of specific filters vertically arranged around a central, cylindrical electrostatic filter to facilitate removal of particles from the air. Removable filters include a pre-filter, an activated carbon filter and a cold catalyst filter, in addition to the electrostatic cylindrical filter. Additional filters or alternate filters may be used, so long as there is no negative impact on the system efficiency and effectiveness.

Abstract: A cooking control system having a temperature probe and a cooking appliance is described for permitting temperature target cooking of foods. The probe includes a metallic insertable portion with a sheathed tip and a temperature sensor positioned therein, a flexible heat-resistant wire coupled to the temperature sensor, and a jack coupled to the flexible, heat-resistant wire opposite the metallic insertable portion. The cooking appliance includes a heating unit, an housing, a temperature reader, and an alpha-numerical display. In use, the temperature sensor produces a signal in response to a temperature sensed at the sheathed tip and the heat-resistant wire and jack transmit the signal produced by the temperature sensor to the port of the cooking appliance. The temperature reader within the housing is coupled to the port and configured to accept and accurately convert the signal produced by the temperature sensor to a number representing the temperature sensed by the sensor and display the number for the user.

Abstract: A temperature control system for appliances, such as an electric grill, air fryer, vacuum blender, convection oven, induction cooker (e.g., wok), coffeemaker, etc. The control system comprises digital circuitry for controlling temperature of the appliance, and includes a first safety component in the circuitry for stopping the heating function at a threshold parameter, such as a maximum temperature, and a second safety component in the circuitry for stopping the heating function at a second threshold temperature if the first safety component fails at the first threshold temperature. The first and second safety components, preferably switches or fuses, are connected in series to establish a redundant safety mechanism.

Abstract: An air purifying system having a series of specific filters stacked to facilitate removal of particles from the air. Removable filters include a pre-filter, a HEPA electrostatic filter, an activated carbon filter and a cold catalyst filter. Additional filters or alternate filters may be used, so long as there is no negative impact on the system efficiency and effectiveness.

Abstract: A cooking control system having a temperature probe and a cooking appliance is described for permitting temperature target cooking of foods. The probe includes a metallic insertable portion with a sheathed tip and a temperature sensor positioned therein, a flexible heat-resistant wire coupled to the temperature sensor, and a jack coupled to the flexible, heat-resistant wire opposite the metallic insertable portion. The cooking appliance includes a heating unit, an housing, a temperature reader, and an alpha-numerical display. In use, the temperature sensor produces a signal in response to a temperature sensed at the sheathed tip and the heat-resistant wire and jack transmit the signal produced by the temperature sensor to the port of the cooking appliance. The temperature reader within the housing is coupled to the port and configured to accept and accurately convert the signal produced by the temperature sensor to a number representing the temperature sensed by the sensor and display the number for the user.

Abstract: A connection for a subarchitectural workspace includes a first structure with a first end and a second end opposite the first end and a second structure with a first end and a second end opposite the first end. The connection assembly further includes a first bracket with a first fine adjustment surface mounted to the first structure, a second bracket with a second fine adjustment surface that engages the first fine adjustment surface, and a clamping mechanism that applies a clamping force to the first and second fine adjustment surfaces to pull the first and second structures together.

Abstract: This disclosure relates to particles, compositions, methods of making, and methods of use thereof.

Abstract: A connection for a subarchitectural workspace includes a first structure with a first end and a second end opposite the first end and a second structure with a first end and a second end opposite the first end. The connection assembly further includes a first bracket with a first fine adjustment surface mounted to the first structure, a second bracket with a second fine adjustment surface that engages the first fine adjustment surface, and a clamping mechanism that applies a clamping force to the first and second fine adjustment surfaces to pull the first and second structures together.

Abstract: A temperature control system for appliances, such as an electric grill, air fryer, vacuum blender, convection oven, induction cooker (e.g., wok), coffeemaker, etc. The control system comprises digital circuitry for controlling temperature of the appliance, and includes a first safety component in the circuitry for stopping the heating function at a threshold parameter, such as a maximum temperature, and a second safety component in the circuitry for stopping the heating function at a second threshold temperature if the first safety component fails at the first threshold temperature. The first and second safety components, preferably switches or fuses, are connected in series to establish a redundant safety mechanism.

Abstract: Provided herein are compositions and methods for the treatment of diseases, such as hyperproliferative diseases, employing compounds formulated for pharmaceutical and research use via nanoparticles.

Abstract: Provided herein are compositions and methods for the treatment of diseases, such as hyperproliferative diseases, employing compounds formulated for pharmaceutical and research use via nanoparticles.

Abstract: An extendable fluid transport apparatus for conveyance of a fluid to a remote surface. A rigid fluid tube (300) receives fluid and is in fluid communication and interconnection with a flexible flex tube (400) which is in fluid communication and interconnection with a connection means proximal a telescoping tube (200) second end for conveyance of a fluid, including paint, to a distant surface. The telescoping tube (200) is slidably received into a casing (100). The flex tube is received through a casing slot (120) and a telescoping tube slot (240) into the telescoping tube.

Abstract: An EXTENDABLE FLUID TRANSPORT APPARATUS for conveyance of a fluid to a remote surface. A rigid fluid tube (300) receives fluid and is in fluid communication and interconnection with a flexible flex tube (400) which is in fluid communication and interconnection with a connection means proximal a telescoping tube (200) second end for conveyance of a fluid, including paint, to a distant surface. The telescoping tube (200) is slidably received into a casing (100). The flex tube is received through a casing slot (120) and a telescoping tube slot (240) into the telescoping tube.

Abstract: The present invention relates to a delatching mechanism for an electronic module, such as an opto-electronic transceiver or a copper transceiver, for locking the electronic module in a host cage. The delatching mechanism enables a conventional small form factor (SFP) sized module to be unlatched while a cable remains engaged therein. A manually engageable lever, such as a bail handle, is rotatably connected on one end of a pivoting latch, and includes a projection for abutting against the module housing for distributing the force applied to the bail to one end of the pivoting latch, whereby the other end of the pivoting latch rotates away from engagement with the host cage.

Abstract: The present invention relates to an electronic module, such as an opto-electronic transceiver or a copper transceiver, for plugging into a host receptacle. In an effort to eliminate the use of costly and inefficient sheet metal spring fingers for reducing EMI emissions, the present invention proposes to use solid conductive projections extending outwardly from the sides and top of the module housing. However, in highly populated host receptacles, adjacent cages often share a common sheet metal wall, which will deform when a module with a solid projection extending therefrom is inserted, thereby making insertion of an adjacent module very difficult. The present invention eliminates this problem by vertically offsetting projections on the opposite sides of the housing so no two projections are in the same horizontal plane.

Abstract: A wireless patient monitor is adapted to communicate with any one of plural medical telemetry networks, each having one or more central stations, where each network is configured to communicate via wireless communications using one of multiple different communications settings. The monitor includes one or more sensor inputs for receiving vital signs data from a patient, a wireless transceiver, and a controller coupled to receive the vital signs data via the one or more sensor inputs and to communicate with a network via the transceiver. The monitor also includes a display device and is controllable by the controller to automatically display a notification to a user of the monitor upon establishing communications with the at least one central station. There is also a method of monitoring a patient and a wireless medical telemetry system.