Abstract: Apparatus including an optical signal generator, a data transmission path, and an optical signal receiver. Optical signal generator includes a coherent light source for generating a spectrum of carrier signals at different carrier frequencies, an optical demultiplexer that receives and separates the different carrier signals into separate optical paths, a pair of optical modulators located in each of the separate optical paths to modulate each different carrier signal with a data signal and produce an upper and lower sideband pair at each of the different carrier frequencies, and an optical interleaver to combine the upper and lower sideband pairs into an optical super-channel of interleaved sub-bands. Optical signal receiver includes a demodulator for extracting the data signals. Optical modulators are configured to reuse each carrier signal to transmit different data in each of the upper sideband and the lower sideband and increase the capacity of the super-channel. Also a method.

Abstract: The present invention relates to a tight space wrench device comprised of a wrench member attached to at least one chain with at least one loop that functions as a handle. The wrench member may have any wrench head known in the art that can be positioned on a fastener. The chain can then be positioned in any area away from the fastener wherein a user can comfortably grip the loop without the risk of injury to their hand. Then, a user can pull the chain to rotate the wrench head clockwise or counterclockwise.

Abstract: Provided herein are methods, therapeutic agents and composition for treating a CNS-related disorder.

Abstract: The present invention provides a novel isolated succinate prodrug as the free compound or a salt, hydrate, solvate or complex thereof being cell permeable and aimed for increasing the ATP-production in mitochondria. The compound is useful in the medical treatment of a range of diseases, in nutritional supplements, nutricosmetics and in cosmetics.

Abstract: The present invention provides a novel isolated succinate prodrug as the free com-pound or a salt, hydrate, solvate or complex thereof being cell permeable and aimed for increasing the ATP-production in mitochondria. The compound is useful in the medical treatment of a range of diseases, in nutritional supplements, nutricosmetics and in cosmetics.

Abstract: The present invention provides a novel isolated succinate prodrug as the free com-pound or a salt, hydrate, solvate or complex thereof being cell permeable and aimed for increasing the ATP-production in mitochondria. The compound is useful in the medical treatment of a range of diseases, in nutritional supplements, nutricosmetics and in cosmetics.

Abstract: Provided herein are methods, therapeutic agents and composition for treating a CNS-related disorder.

Abstract: The present invention relates to sanglifehrin macrocyclic analogues according to Formula (I), particularly for use in treatment of cancer, especially liver cancer.

Abstract: A downhole relative positioning system utilizes electromagnetic and survey measurements from a first well to calibrate a formation model, which is then used to improve the interpretation of measurements from a second well. Since the methods described herein utilize a differential approach, even though the exact position of each wellbore may not be accurately identified, their relative positions can be accurately identified.

Abstract: Provided herein are screening methods and systems for the identification and evaluation of candidate GABAergic modulators. These candidate agents or compounds are useful for treating or preventing CNS-related disorders.

Abstract: The present invention relates to uses of sanglifehrin macrocyclic analogues in treatment of cancer, especially liver cancer.

Abstract: The present invention provides novel liver-targeted prodrugs of mitochondrial proton ionophores. These compounds have utility in medicine including their use in treatment of diseases such as NASH and NAFLD.

Abstract: The invention comprises building panel assemblies for use in the construction of new homes, commercial buildings and extensions of one or more storeys. There is provided a rectangular structural insulated panel (SIP) (10), which comprises a pair of spaced-apart containment boards (12?, 12?) an inner insulating core (13) and a low profile peripheral external rigid frame (14), preferably of metal, e.g. steel, extending around the entire periphery of the spaced-apart boards (12?, 12?), the insulating core (13) having spaced-apart slots (16), which also extend around the entire periphery of the panel.

Abstract: A magnetic ranging system utilizes the natural shape of magnetic fields for steering and/or landing of one wellbore in relation to another wellbore.

Abstract: A downhole relative positioning system utilizes electromagnetic and survey measurements from a first well to calibrate a formation model, which is then used to improve the interpretation of measurements from a second well. Since the methods described herein utilize a differential approach, even though the exact position of each wellbore may not be accurately identified, their relative positions can be accurately identified.

Abstract: The invention comprises building panel assemblies for use in the construction of new homes, commercial buildings and extensions of one or more storeys. There is provided a rectangular structural insulated panel (SIP) (10), which comprises a pair of spaced-apart containment boards (12?, 12?) an inner insulating core (13) and a low profile peripheral external rigid frame (14), preferably of metal, e.g. steel, extending around the entire periphery of the spaced-apart boards (12?, 12?), the insulating core (13) having spaced-apart slots (16), which also extend around the entire periphery of the panel.

Abstract: A method for increasing the molecular diversity of polyketides and non-ribosomal peptides by using recombination to efficiently increase or decrease the number of modules in the polyketide synthase or non-ribosomal peptide synthetase encoding the polyketide or peptide.

Abstract: An artificial toolface reference system includes a power supply providing current to a ground lead and a reference lead. A ground point is coupled to the ground lead and in electrical connection with the ground. A reference wellbore includes a reference conductor in electrical connection with the ground. The reference conductor is in electrical connection with the reference lead. A guidance sensor positioned outside the reference wellbore includes at least one magnetometer. The power supply may be used to provide a current through the reference conductor, the ground, and the ground point such that a reference magnetic field is generated along the reference conductor. The guidance sensor may measure the reference magnetic field with a magnetometer. An artificial magnetic toolface may be calculated therefrom.

Abstract: A method for increasing the molecular diversity of polyketides and non-ribsomomal peptides by using recombination to efficiently increase or decrease the number of modules in the polyketide synthase or non-ribosomal peptide synthetase encoding said polyketide or peptide.

Abstract: The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).