Abstract: Described here are patches, systems, and methods for measuring glucose. In general, the patches comprise a microfluidic collection layer and a detector, and the systems comprise a patch and a measurement device. Some methods for measuring glucose comprise cleaning the skin surface, collecting sweat from the skin surface using a microfluidic collection device, and measuring the collected glucose. Other methods comprise cleaning the skin surface, collecting sweat in a patch comprising a microfludic collection layer, and measuring glucose collected in the patch. Still other methods comprise cleaning the skin surface, collecting a first sweat sample from the skin surface in a patch comprising a microfludic collection layer and a detector layer, transferring the first sweat sample from the collection layer to the detector layer, measuring glucose in the first sweat sample, and repeating the collection, transferring, and measuring steps at least once.

Abstract: A system and method for evaluating a multiprocessor system having multiple processors coupled via a system bus is disclosed. A test vector is executed on a processor under test. While the test vector is being executed, an instruction that causes a transaction to be issued on the system bus is executed on another processor, thereby stressing the first processor.

Abstract: A patient monitoring system implemented by a service provider for users via recording a patient's analytes measurements by non-invasively interrogating a skin patch placed upon the patient's skin surface. The system includes an input module to provide a device to measure analytes from a patient, such as a measurement of the blood glucose level. The measurement is shared among a plurality of output devices such as computers, personal digital assistants (PDAs), cellular phones, and pagers that are stationed or held by various users, such as doctors, patients, researchers, pharmacies, labs, and health insurers. In addition, behavioral attributes are recorded and correlated with the analytes measurements to generate a profile. The profile is selectively sent to output devices based on the user profile corresponding to the output device. Also, access to the profile is monitored by a security module that encrypts the profile to prevent access by un-authorized users.

Abstract: Described here are patches, systems, and methods for measuring glucose. In general, the patches comprise a microfluidic collection layer and a detector, and the systems comprise a patch and a measurement device. Some methods for measuring glucose comprise cleaning the skin surface, collecting sweat from the skin surface using a microfluidic collection device, and measuring the collected glucose. Other methods comprise cleaning the skin surface, collecting sweat in a patch comprising a microfludic collection layer, and measuring glucose collected in the patch. Still other methods comprise cleaning the skin surface, collecting a first sweat sample from the skin surface in a patch comprising a microfludic collection layer and a detector layer, transferring the first sweat sample from the collection layer to the detector layer, measuring glucose in the first sweat sample, and repeating the collection, transferring, and measuring steps at least once.

Abstract: A method for automatically adjusting the intensity of a lighting element based on feedback from internal and external sources of light is disclosed herein. A photosensitive element senses ambient light and transmits an electrical signal proportional to the intensity of the ambient light to a driver. The driver automatically adjusts the intensity of the lighting element based on this feedback to provide optimal conditions for the application. In addition, the lighting element transmits an electrical signal proportional to the intensity of the light from the lighting element to a driver. The driver further adjusts the intensity of the lighting element based on this feedback to provide optimal conditions for the application.

Abstract: The present invention introduces methods and circuits to amplify audio signals for driving speakers. An additional feedback circuit is added in an audio amplifier to couple the amplifier stage and output stage of the audio amplifier. The feedback circuit turned off as long as output voltages of the audio amplifier are not near saturation. The feedback circuit is turned on to reduce audible noises if output voltages of the audio amplifier are near saturation.

Abstract: The present disclosure introduces a simple method and apparatus for converting DC power to AC power for driving discharge lamps such as a cold cathode fluorescent lamp (CCFL), an external electrode fluorescent lamp (EEFL), or a flat fluorescent lamp (FFL). Among other advantages, the invention allows the proper protection under short circuit conditions for applications where the normal lamp current is greater than safe current limit.

Abstract: In one embodiment, an apparatus is provided. The apparatus includes a power bridge suitable for coupling to a CCFL (cold cathode fluorescent lamp) load and providing an operating current to the load. The apparatus also includes a replica component coupled to the power bridge to provide a replica current proportional to the operating current. The apparatus further includes a reference component receptacle to produce a reference current in conjunction with an external reference component. The apparatus also includes a comparison component coupled to the replica component and the reference component to compare the replica component to the reference component.

Abstract: A technique is described that reduces parasitic losses in circuits used to drive current through a load. An example of a system according to the technique includes four switches in series with five pins such that one pin is connected to ground. An example of an apparatus according to the technique may include four switches in series with two switches connected to ground and to a load and two switches connected to a power source. An example of a method according to the technique involves producing a voltage waveform having three phases.

Abstract: The described DC to AC inverter efficiently controls the amount of electrical power used to drive a cold cathode fluorescent lamp (CCFL). The output is a fairly pure sine wave which is proportional to an input control voltage. The output waveform purity is ensured by driving a symmetrical rectangular waveform into a second-order, low pass filter at the resonant frequency of the filter for all conditions of line voltage and delivered power. Operating stress on the step-up transformer is minimized by placing the load (lamp) directly across the secondary side of the transformer. When configured to regulate delivered power, the secondary side may be fully floated which practically eliminates a thermometer effect on the operation of the lamp. All of the active elements, including the power switches, may be integrated into a monolithic silicon circuit.

Abstract: Described are devices, methods, and kits for non-invasively measuring glucose. In general, the devices comprise skin patches for placement on a skin surface and measurement devices for measuring glucose collected in the patches. The patches may include an adhesive material, a collection layer, an interface layer, and a sweat-permeable membrane. The sweat-permeable membrane is configured to act as a barrier to epidermal contaminants and glucose brought to the skin surface via diffusion. In this way, non-correlatable skin surface glucose will not be measured. The patches may further include components to induce a local sweat response. The measurement device typically includes a display, a processor, and a measurement mechanism. The methods typically include the steps of wiping the skin surface with a wipe containing at least one solvent for removing glucose, placing a patch on a skin surface, and measuring glucose collected in the patch. Kits comprising the patch and measurement device are also described.

Abstract: A technique for driving one or more EEFLs, having first and second ends, in a bank of EEFLs involves driving the EEFLs at both the first and second ends. In a non-limiting embodiment, a device constructed according to the technique may include a bank of EEFLs connected in parallel. The device may further include a first transformer, wherein a first of the secondary windings of the first transformer is coupled to the first end of the bank of EEFLs. The device may further include a second transformer, wherein a first of the secondary windings of the second transformer is coupled to the second end of the bank of EEFLs.

Abstract: The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), which is preferably human IGF-IR. The invention also relates to human anti-IGF-IR antibodies, including chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulin molecules derived from anti-IGF-IR antibodies and nucleic acid molecules encoding such molecules. The present invention also relates to methods of making anti-IGF-IR antibodies, pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-IGF-IR antibodies.

Abstract: The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), which is preferably human IGF-IR. The invention also relates to human anti-IGF-IR antibodies, including chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulin molecules derived from anti-IGF-IR antibodies and nucleic acid molecules encoding such molecules. The present invention also relates to methods of making anti-IGF-IR antibodies, pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-IGF-IR antibodies.

Abstract: A method of driving a lamp that uses a DC to AC inverter that is connected to a primary winding of a transformer is disclosed. The inverter frequency is variable, and in one embodiment, may be controlled by a voltage controlled oscillator. Circuitry is included that monitors the phase relationship between a voltage across a secondary of the transformer and a current through the primary of the transformer. The circuitry monitors the phase relationship and adjusts the inverter frequency, such as by adjusting voltage controlled oscillator, so that the phase relationship is maintained at a predetermined relationship.

Abstract: The invention is directed to methods for the a method for treating overexpression of the erbB2 in a mammal in need of treatment by administering to the mammal a therapeutically effective amount of a first inhibitor of an erbB2 receptor and then, after an interval of less than 24 hours, administering to the mammal from one to six therapeutically effective amounts of the same or different inhibitor of the erbB2 receptor. The invention is also directed to a slow daily infusion of the erbB2 inhibitor. The overexpression of the erbB2 receptor can result in abnormal cell growth and lead to cancer. By the methods of the invention, the efficacy and safety of the inhibitors is increased. The invention is also directed to kits for facilitating the dose administration method of the invention.

Abstract: The present invention relates to a stable crystalline form of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride designated the B polymorph, its production in essentially pure form, and its use. The invention also relates to the pharmaceutical compositions containing the stable polymorph B form of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine as hydrochloride, as well other forms of the compound, and to methods of treating hyperproliferative disorders, such as cancer, by administering the compound.

Abstract: A method of driving a lamp that uses a DC to AC inverter that is connected to a primary winding of a transformer is disclosed. The inverter frequency is variable, and in one embodiment, may be controlled by a voltage controlled oscillator. Circuitry is included that monitors the phase relationship between a voltage across a secondary of the transformer and a current through the primary of the transformer. The circuitry monitors the phase relationship and adjusts the inverter frequency, such as by adjusting voltage controlled oscillator, so that the phase relationship is maintained at a predetermined relationship.

Abstract: A controlled offset amplifier comprises an input stage including two transistors. The two transistors have different threshold voltage implants. The amplifier also includes an amplification stage that receives a signal from the input stage and provides an output signal related to the signal.

Abstract: A system and method for evaluating a multiprocessor system having multiple processors coupled via a system bus is disclosed. A test vector is executed on a processor under test. While the test vector is being executed, an instruction that causes a transaction to be issued on the system bus is executed on another processor, thereby stressing the first processor.