Patents by Inventor James Mueller

James Mueller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250179413
    Abstract: Systems, methods, and machine learning tools are described for controlled growth of mycelium such as aerial mycelium. Methods can include providing one or more growth environments including one or more inocula and a substrate, providing a monitoring system that transmits data to one or more processors and includes a machine learning tool that monitors environmental conditions and/or mycelium growth, and applying the machine learning tool to determine one or more changes to environmental conditions based on the data. The data can include real-time monitoring information on the environmental conditions or mycelium growth within the one or more growth environments. Further machine learning models are provided for selection and control of additional mycelium growth conditions.
    Type: Application
    Filed: November 29, 2024
    Publication date: June 5, 2025
    Inventors: Eben D. Bayer, Peter James Mueller, Julian Noah Rosenberg, Orkan Telhan, Jacob Michael Winiski
  • Publication number: 20250176479
    Abstract: Systems and methods for providing supplemental growth conditions to substrates, growth matrices, and growing aerial mycelium materials are provided which allow for enhanced aerial mycelial growth or targeted mycelial growth from either select or entire portions of substrates, growth matrices, or growing aerial mycelial materials (such as panels), or within select or entire portions of growth environments, when compared to growth levels and/or attributes resulting from base-line growth conditions.
    Type: Application
    Filed: November 29, 2024
    Publication date: June 5, 2025
    Inventors: Eben D. Bayer, Scott Elliot Baker, Gavin Reim McIntyre, Peter James Mueller, Jeff Andrew Mundt, Julian Noah Rosenberg, Orkan Telhan, Jacob Michael Winiski
  • Publication number: 20250017250
    Abstract: This application relates generally to aerial mycelium and methods of making aerial mycelium suitable for use as a food or textile product or ingredient. The aerial mycelium can be grown using a growth matrix provided into a growth environment and introducing aqueous mist into the growth environment. The aqueous mist has a mean mist deposition rate to allow for aerial mycelial growth from the growth matrix.
    Type: Application
    Filed: September 27, 2024
    Publication date: January 16, 2025
    Inventors: Jacob Michael Winiski, Alex James Carlton, Gavin Reim McIntyre, Peter James Mueller, Eben D. Bayer, Asa Trench Snyder, Meghan Anne O'Brien, Jessica Hannah Kaplan-Bie, Alex Stephen Friedman, Russell Allan Hazen, Stephen Lomnes
  • Publication number: 20240164262
    Abstract: Apparatus and processes to grow a biomaterial made of aerial mycelium by sensing and controlling airborne mist concentration, regardless of relative humidity. A growth matrix comprising a growth medium and a fungus, is grown under controlled environmental conditions to produce a mycelium product. To control growth conditions precisely and efficiently, airborne mist is electronically detected using one or more sensors, configured to measure airborne mist concentration visually, optically, chemically, electromagnetically, or by laser, ultrasonically, with radar, or other means. Electronic detection of airborne mist using one or more sensors generates a signal that is transmitted to a processor that can either maintain, increase, or decrease airborne mist concentration in a growth environment. The present invention provides processes of growing mycelium that are repeatable and resource efficient, while providing high quality and quantity mycelium-based products.
    Type: Application
    Filed: November 20, 2023
    Publication date: May 23, 2024
    Inventors: Peter James Mueller, Asa Trench Snyder, Ian Thomas Bonesteel, Chirayu Jain, Eben D. Bayer, Alex Stephen Friedman
  • Publication number: 20240043787
    Abstract: Methods are disclosed for generating aerial mycelium, such as mycological material comprising solely mycelia from depleted substrate or depleted and rejuvenated substrate. Alternatively, methods are disclosed for generating mycelia and mushrooms from depleted substrate or depleted and rejuvenated substrate. Alternative methods are disclosed for generating differentiated mycelium materials using depleted substrate or depleted and rejuvenated substrate. The mycelia products that are generated can be used in the food industry (e.g., as a meat analog) and in other industries, such as textiles, packaging, and others. The present invention provides systems and methods for generating mycelia that are repeatable and energy efficient, while providing consistently high quality and quantity mycelium-based products.
    Type: Application
    Filed: July 27, 2023
    Publication date: February 8, 2024
    Inventors: Hazel A. Robertson, Molly Elizabeth Boutin, Emmie Marie Knobloch, Gavin Reim McIntyre, Peter James Mueller, Alex James Carlton, Meghan Anne O’Brien
  • Publication number: 20230257748
    Abstract: The present invention relates to an A1CF inhibitor for use in treatment of an HBV infection, in particular a chronic HBV infection. The invention in particular relates to the use of A1CF inhibitors for destabilizing cccDNA, such as HBV cccDNA. The invention also relates to nucleic acid molecules which are complementary to A1CF and capable of reducing the level of an A1CF mRNA. Also comprised in the present invention is a pharmaceutical composition and its use in the treatment of a HBV infection.
    Type: Application
    Filed: February 17, 2023
    Publication date: August 17, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Dennis JUL HANSEN, Souphalone LUANGSAY, Alan James MUELLER-BRECKENRIDGE, Lykke PEDERSEN, Johanna Marie POSE VICENTE
  • Publication number: 20230193263
    Abstract: The present invention relates to a SBDS inhibitor for use in treatment of an HBV infection, in particular a chronic HBV infection. The invention in particular relates to the use of SBDS inhibitors for destabilizing cccDNA, such as HBV cccDNA. The invention also relates to nucleic acid molecules which are complementary to SBDS and capable of reducing the level of a SBDS mRNA. Also comprised in the present invention is a pharmaceutical composition and its use in the treatment of a HBV infection.
    Type: Application
    Filed: June 21, 2022
    Publication date: June 22, 2023
    Inventors: Souphalone Luangsay, Alan James Mueller-Breckenridge, Lykke Pedersen, Johanna Marie Walther
  • Publication number: 20230183692
    Abstract: The present invention relates to a SEPT9 inhibitor for use in treatment of an HBV infection, in particular a chronic HBV infection. The invention in particular relates to the use of SEPT9 inhibitors for destabilizing cccDNA, such as HBV cccDNA. The invention also relates to nucleic acid molecules which are complementary to SEPT9 and capable of reducing the level of a SEPT9 mRNA. Also comprised in the present invention is a pharmaceutical composition and its use in the treatment of a HBV infection.
    Type: Application
    Filed: June 21, 2022
    Publication date: June 15, 2023
    Inventors: Lykke Pedersen, Souphalone Luangsay, Johanna Marie Walther, Alan James Mueller-Breckenridge
  • Publication number: 20230120063
    Abstract: The present invention relates to a SARAF inhibitor for use in treatment of an HBV infection, in particular a chronic HBV infection. The invention in particular relates to the use of SARAF inhibitors for destabilizing cccDNA, such as HBV cccDNA. The invention also relates to nucleic acid molecules which are complementary to SARAF and capable of reducing the level of a SARAF mRNA. Also comprised in the present invention is a pharmaceutical composition and its use in the treatment of a HBV infection.
    Type: Application
    Filed: June 21, 2022
    Publication date: April 20, 2023
    Inventors: Lykke Pedersen, Souphalone Luangsay, Johanna Marie Walther, Alan James Mueller-Breckenridge
  • Publication number: 20230118138
    Abstract: The present invention relates to a SCAMP3 inhibitor for use in treatment of an HBV infection, in particular a chronic HBV infection. The invention in particular relates to the use of SCAMP3 inhibitors for destabilizing cccDNA, such as HBV cccDNA. The invention also relates to nucleic acid molecules which are complementary to SCAMP3 and capable of reducing the level of a SCAMP3 mRNA. Also comprised in the present invention is a pharmaceutical composition and its use in the treatment of a HBV infection.
    Type: Application
    Filed: June 21, 2022
    Publication date: April 20, 2023
    Inventors: Lykke Pedersen, Souphalone Luangsay, Johanna Marie Walther, Alan James Mueller-Breckenridge
  • Publication number: 20230122751
    Abstract: The present invention relates to a COPS3 inhibitor for use in treatment of an HBV infection, in particular a chronic HBV infection. The invention in particular relates to the use of COPS3 inhibitors for destabilizing cccDNA, such as HBV cccDNA. The invention also relates to nucleic acid molecules which are complementary to COPS3 and capable of reducing the level of a COPS3 mRNA. Also comprised in the present invention is a pharmaceutical composition and its use in the treatment of a HBV infection.
    Type: Application
    Filed: June 21, 2022
    Publication date: April 20, 2023
    Inventors: Lykke Pedersen, Souphalone Luangsay, Johanna Marie Walther, Alan James Mueller-Breckenridge
  • Publication number: 20230056666
    Abstract: The invention describes a methodology for production of a secondary extra-particle fungal matrix for application as a mycological material, manufactured via a Type II actively aerated static packed-bed bioreactor. A pre-conditioned air stream is passed through a substrate of discrete elements inoculated with a filamentous fungus to form an isotropic inter-particle hyphal matrix between the discrete elements. Continued feeding of the air through the substrate of discrete elements and isotropic inter-particle hyphal matrixes develops an extra-particle hyphal matrix that extends from an isotropic inter-particle hyphal matrix in the direction of airflow into a void space within the vessel.
    Type: Application
    Filed: June 9, 2022
    Publication date: February 23, 2023
    Inventors: Jacob Michael Winiski, Peter James Mueller
  • Publication number: 20220361424
    Abstract: The process for producing mycelium biomaterial provides fresh oxygen to the growing mycelium biomaterial while removing waste heat and waste carbon dioxide by forced aeration through large volumes of material. In a first phase of fungal expansion, humidified air at a programmed temperature is passed upwardly and through a fungal inoculated substrate of discrete particles to allow the fungal inoculum to expand and dominate the substrate. Nutrient is added to the inoculated mixture and a second phase of fungal expansion is performed wherein humidified air at a programmed temperature is passed upwardly and through the nutrient enriched fungal inoculated substrate to allow the fungal inoculum to bond the discrete particles into a self-supporting biocomposite. The process and apparatus of the invention allows for the processing of grown materials bound by mycelium at depths of greater than 6? and particularly in the range of from 24? to 28?.
    Type: Application
    Filed: May 26, 2022
    Publication date: November 17, 2022
    Inventors: Peter James Mueller, Jacob Michael Winiski, Meghan Anne O'Brien
  • Publication number: 20220354068
    Abstract: An improved mycelium in the form of an edible aerial mycelium that is suitable for use as a food product, including a food ingredient for making mycelium-based food, such as bacon. A method of making an edible aerial mycelium suitable for use as a food product, including a food ingredient. An edible product containing an edible aerial mycelium, and a method of making an edible product comprising an edible aerial mycelium, such as a mycelium-based bacon. A mycelium-based food product having a texture that is analogous to a whole-muscle meat product, wherein that whole-muscle meat product is bacon.
    Type: Application
    Filed: May 3, 2022
    Publication date: November 10, 2022
    Inventors: Alex James Carlton, Russell Allan Hazen, Nicholas Ruscitto, Alex Stephen Friedman, Gavin Reim McIntyre, Peter James Mueller, Eben D. Bayer, Stephen Lomnes, Asa Trench Snyder, Meghan Anne O'Brien, Jessica Hannah Kaplan-Bie, Damen Donald Schaak, Vivian Lee Kutikov
  • Publication number: 20220354152
    Abstract: This application relates generally to aerial mycelium and methods of making aerial mycelium suitable for use as a food or textile product or ingredient. Such a food product or ingredient can include edible aerial mycelium having a texture that is analogous to a whole-muscle meat product, such as for example mycelium-based bacon. Such a textile product or ingredient can be used in the manufacture of mycelium-based textile products, leather-like materials, petroleum-based product alternatives, or foams.
    Type: Application
    Filed: May 3, 2022
    Publication date: November 10, 2022
    Inventors: Jacob Michael Winiski, Alex James Carlton, Gavin Reim McIntyre, Peter James Mueller, Eben D. Bayer, Asa Trench Snyder, Meghan Anne O'Brien, Jessica Hannah Kaplan-Bie, Alex Stephen Friedman, Russell Allan Hazen, Stephen Lomnes
  • Patent number: 11359174
    Abstract: The invention describes a methodology for production of a secondary extra-particle fungal matrix for application as a mycological material, manufactured via a Type II actively aerated static packed-bed bioreactor. A pre-conditioned air stream is passed through a substrate of discrete elements inoculated with a filamentous fungus to form an isotropic inter-particle hyphal matrix between the discrete elements. Continued feeding of the air through the substrate of discrete elements and isotropic inter-particle hyphal matrixes develops an extra-particle hyphal matrix that extends from an isotropic inter-particle hyphal matrix in the direction of airflow into a void space within the vessel.
    Type: Grant
    Filed: August 23, 2019
    Date of Patent: June 14, 2022
    Assignee: Ecovative Design LLC
    Inventors: Jacob Michael Winiski, Peter James Mueller
  • Patent number: 11343979
    Abstract: The process for producing mycelium biomaterial provides fresh oxygen to the growing mycelium biomaterial while removing waste heat and waste carbon dioxide by forced aeration through large volumes of material. In a first phase of fungal expansion, humidified air at a programmed temperature is passed upwardly and through a fungal inoculated substrate of discrete particles to allow the fungal inoculum to expand and dominate the substrate. Nutrient is added to the inoculated mixture and a second phase of fungal expansion is performed wherein humidified air at a programmed temperature is passed upwardly and through the nutrient enriched fungal inoculated substrate to allow the fungal inoculum to bond the discrete particles into a self-supporting biocomposite. The process and apparatus of the invention allows for the processing of grown materials bound by mycelium at depths of greater than 6? and particularly in the range of from 24? to 28?.
    Type: Grant
    Filed: May 22, 2019
    Date of Patent: May 31, 2022
    Assignee: Ecovative Design LLC
    Inventors: Peter James Mueller, Jacob Michael Winiski, Meghan Anne O'Brien
  • Patent number: 10836648
    Abstract: Generating ferrate ex situ by activating persulfate with BOF steel slag fines and/or ferric iron. A persulfate solution flows therethrough or thereover the BOF steel slag within, for example, a filter, fluidized bed or continuously stirred tank reactor. The ex situ generation will produce a leachate that contains multiple reactive oxidant species (ROS) such as hydrogen peroxide (H2O2), superoxide (O2.), sulfate radicals, hydroxyl radicals (OH.) and uniquely ferrate species including Fe IV, V and VI. These ROS will destroy organic compounds, sterilize, and can oxidize inorganics and a wide range of targeted contaminants in distressed water (e.g., drinking water, process water, wastewater, industrial process streams/waters, municipal process streams/waters, landfill leachate, sewage/septic systems, bilge waters, drilling fluids, mine effluents).
    Type: Grant
    Filed: March 11, 2019
    Date of Patent: November 17, 2020
    Inventors: James Mueller, Dennis Grubb, Michael Scalzi
  • Patent number: 10729132
    Abstract: A method for controlling xylophages (e.g., termites, Asian Beetle, Emerald Ash borer, Weevils, Deathwatch Caterpillars, cockroaches) by inhibiting methane production of methanogenic Archaea in the digestive tract thereof. The inhibiting of the critical biochemical pathways specific to the methanogenic Archaea is achieved by contacting the xylophage with one or more antimethanogenic reagent (AMR) compounds. The AMRs may include, for example, naturally-occurring statins (which may be found in red yeast rice) or derivatives thereof, linoleic acid or related compounds, essential oils, certain synthetic compounds or combinations thereof. As a result, the effectiveness of the methanogenic Archaea to produce methane is compromised. This subsequently results into the malfunctioning of the xylophages' digestive system and provides a safe, natural, green and sustainable means of controlling the xylophages.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: August 4, 2020
    Assignee: Environmetal Intellectual Property, Inc.
    Inventors: James Mueller, Michael Scalzi, Antonis Karachalios
  • Publication number: 20200102530
    Abstract: The invention describes a methodology for production of a secondary extra-particle fungal matrix for application as a mycological material, manufactured via a Type II actively aerated static packed-bed bioreactor. A pre-conditioned air stream is passed through a substrate of discrete elements inoculated with a filamentous fungus to form an isotropic inter-particle hyphal matrix between the discrete elements. Continued feeding of the air through the substrate of discrete elements and isotropic inter-particle hyphal matrixes develops an extra-particle hyphal matrix that extends from an isotropic inter-particle hyphal matrix in the direction of airflow into a void space within the vessel.
    Type: Application
    Filed: August 23, 2019
    Publication date: April 2, 2020
    Applicant: Ecovative Design LLC
    Inventors: Jacob Michael Winiski, I, Peter James Mueller