Abstract: A seat positioning system includes a base frame having a pair of forward slots and a pair of rear slots, and a seat frame having a front end and a back end. The seat frame is coupled to the base frame and movable relative to the base frame. A first pair of linkages is slideably coupled to the pair of forward slots and connects the frames. A first pair of locking devices has a locked configuration adapted to prevent the first pair of linkages from sliding relative to the pair of forward slots and an unlocked configuration adapted to allow the first pair of linkages to slide relative to the pair of forward slots. A second pair of linkages slideably is coupled to the pair of rear slots and connects the frames. An actuator is pivotally connected to both the seat frame and the base frame and is configured to extend and contract to move the seat frame relative to the base frame.

Abstract: A seat positioning system includes a base frame having a pair of forward slots and a pair of rear slots, and a seat frame having a front end and a back end. The seat frame is coupled to the base frame and movable relative to the base frame. A first pair of linkages is slideably coupled to the pair of forward slots and connects the frames. A first pair of locking devices has a locked configuration adapted to prevent the first pair of linkages from sliding relative to the pair of forward slots and an unlocked configuration adapted to allow the first pair of linkages to slide relative to the pair of forward slots. A second pair of linkages slideably is coupled to the pair of rear slots and connects the frames. An actuator is pivotally connected to both the seat frame and the base frame and is configured to extend and contract to move the seat frame relative to the base frame.

Abstract: A vehicle may include a flutter resistant caster. The vehicle may include a frame, a drive wheel coupled to the frame, a caster housing coupled to the frame, a caster, a locking element, a first bearing, and a biasing element. The caster housing may include an opening. The caster may include a caster wheel and a caster stem extending through the opening in the caster housing. The caster stem may be configured to rotate relative to the caster housing. The locking element may be coupled to the caster stem. The first bearing may be coupled to the caster stem. The biasing element may be coupled to the caster stem. The biasing element may be configured to exert a force on the first bearing.

Abstract: A motorized vehicle may include a frame, a drive wheel coupled to the frame, a motor operatively coupled to the drive wheel, and an anti-tip assembly including a first anti-tip wheel. The anti-tip assembly may have a first configuration wherein the first anti-tip wheel is both pivotable about a pivot axis relative to the frame and translatable along a sliding axis.

Abstract: A vehicle may include a flutter resistant caster. The vehicle may include a frame, a drive wheel coupled to the frame, a caster housing coupled to the frame, a caster, a locking element, a first bearing, and a biasing element. The caster housing may include an opening. The caster may include a caster wheel and a caster stem extending through the opening in the caster housing. The caster stem may be configured to rotate relative to the caster housing. The locking element may be coupled to the caster stem. The first bearing may be coupled to the caster stem. The biasing element may be coupled to the caster stem. The biasing element may be configured to exert a force on the first bearing.

Abstract: A vehicle may include a flutter resistant caster. The vehicle may include a frame, a drive wheel coupled to the frame, a caster housing coupled to the frame, a caster, a locking element, a first bearing, and a biasing element. The caster housing may include an opening. The caster may include a caster wheel and a caster stem extending through the opening in the caster housing. The caster stem may be configured to rotate relative to the caster housing. The locking element may be coupled to the caster stem. The first bearing may be coupled to the caster stem. The biasing element may be coupled to the caster stem. The biasing element may be configured to exert a force on the first bearing.

Abstract: A seat positioning system includes a base frame having a pair of forward slots and a pair of rear slots, and a seat frame having a front end and a back end. The seat frame is coupled to the base frame and movable relative to the base frame. A first pair of linkages is slideably coupled to the pair of forward slots and connects the frames. A first pair of locking devices has a locked configuration adapted to prevent the first pair of linkages from sliding relative to the pair of forward slots and an unlocked configuration adapted to allow the first pair of linkages to slide relative to the pair of forward slots. A second pair of linkages slideably is coupled to the pair of rear slots and connects the frames. An actuator is pivotally connected to both the scat frame and the base frame and is configured to extend and contract to move the scat frame relative to the base frame.

Abstract: A powered wheelchair comprises a frame and an arm assembly that includes an arm that is pivotably coupled to the frame. The arm assembly includes a wheel coupled to the arm. A drive system is coupled to the arm assembly and configured to drive a drive wheel. An arm limiter is pivotably coupled to the suspension and coupled to one or more of the arm assembly and the drive system in an engaged position. The arm limiter is configured to limit movement of the arm assembly in the engaged position.

Abstract: A seat positioning system includes a base frame having a pair of forward slots and a pair of rear slots, and a seat frame having a front end and a back end. The seat frame is coupled to the base frame and movable relative to the base frame. A first pair of linkages is slideably coupled to the pair of forward slots and connects the frames. A first pair of locking devices has a locked configuration adapted to prevent the first pair of linkages from sliding relative to the pair of forward slots and an unlocked configuration adapted to allow the first pair of linkages to slide relative to the pair of forward slots. A second pair of linkages slideably is coupled to the pair of rear slots and connects the frames. An actuator is pivotally connected to both the seat frame and the base frame and is configured to extend and contract to move the seat frame relative to the base frame.

Abstract: A powered wheelchair comprises a frame and an arm assembly that includes an arm that is pivotably coupled to the frame. The arm assembly includes a wheel coupled to the arm. A drive system is coupled to the arm assembly and configured to drive a drive wheel. An arm limiter is pivotably coupled to the suspension and coupled to one or more of the arm assembly and the drive system in an engaged position. The arm limiter is configured to limit movement of the arm assembly in the engaged position.

Abstract: The present disclosure provides virtual screening methods utilizing data sets from nucleotide-encoded libraries (e.g., DNA-encoded libraries). These methods allow for high confidence predictions of binding interactions between candidate compounds and proteins of interest useful for the development of therapeutics.

Abstract: A powered wheelchair comprises a frame and an arm assembly that includes an arm that is pivotably coupled to the frame. The arm assembly includes a wheel coupled to the arm. A drive system is coupled to the arm assembly and configured to drive a drive wheel. An arm limiter is pivotably coupled to the suspension and coupled to one or more of the arm assembly and the drive system in an engaged position. The arm limiter is configured to limit movement of the arm assembly in the engaged position.

Abstract: A seat positioning system includes a base frame having a pair of forward slots and a pair of rear slots, and a seat frame having a front end and a back end. The seat frame is coupled to the base frame and movable relative to the base frame. A first pair of linkages is slideably coupled to the pair of forward slots and connects the frames. A first pair of locking devices has a locked configuration adapted to prevent the first pair of linkages from sliding relative to the pair of forward slots and an unlocked configuration adapted to allow the first pair of linkages to slide relative to the pair of forward slots. A second pair of linkages slideably is coupled to the pair of rear slots and connects the frames. An actuator is pivotally connected to both the seat frame and the base frame and is configured to extend and contract to move the seat frame relative to the base frame.

Abstract: A pool jet fitting can include an insert housing defining an insert body, a housing channel, and a base disposed within the housing channel. The base can include an outer sidewall that defines an internal chamber. The fitting has a valve disposed within the internal chamber. The valve includes a valve body, a valve channel that extends into the valve body along the first direction, and a valve opening that extends through the valve body and into the valve channel along a second direction that is angularly offset with respect to the first direction. The valve is movable between a first position whereby the valve opening has a first area through which the water flow moves and a second position whereby the valve opening has a second area through which the water flow moves that is greater than the first area.

Abstract: A pool jet fitting can include an insert housing defining an insert body, a housing channel, and a base disposed within the housing channel. The base can include an outer sidewall that defines an internal chamber. The fitting has a valve disposed within the internal chamber. The valve includes a valve body, a valve channel that extends into the valve body along the first direction, and a valve opening that extends through the valve body and into the valve channel along a second direction that is angularly offset with respect to the first direction. The valve is movable between a first position whereby the valve opening has a first area through which the water flow moves and a second position whereby the valve opening has a second area through which the water flow moves that is greater than the first area.

Abstract: In accordance with an embodiment, a pool jet fitting can include a housing and a redirector coupled to the housing. The housing can include a housing body and a bore that extends through the housing body along a first direction. The bore is configured to receive a water flow. The redirector is disposed within the bore of the housing. The redirector can define an opening through which the water flow moves. The redirector can include an actuator that is configured to automatically move the opening from a first configuration to a second configuration upon application of heat to the water flow by a heater. The water flow through the opening has a first trajectory when the opening is in the first configuration and a second trajectory when the opening is in the second configuration. The second trajectory is different than the first trajectory relative to the first direction.

Abstract: A vehicle is disclosed having a pair of drive wheels, at least one ground-engaging front wheel connected to the frame forward of the drive wheels and at least one ground-contacting anti-tip wheel mounted to the vehicle rearward of the drive wheels. The drive wheels and anti-tip wheels are mounted on common suspension arms, pivoted to the frame of the vehicle behind the drive wheels and resiliently suspended, so that the anti-tip wheels move up and down in response to movements of the drive wheel suspension.

Abstract: An anti-tip system is provided for improving the stability of a powered vehicle, such as a powered wheelchair. The vehicle includes a drive-train assembly which is pivotally mounted to a main structural frame. A suspension system biases the drive-train assembly and its connected anti-tip wheel to a predetermined resting position. The drive-train assembly bi-directionally rotates about a pivot in response to torque applied to or acceleration forces on the vehicle. A linkage arrangement is provided and is characterized by a suspension arm pivotally mounting to the main structural frame about a pivot at one end thereof and an anti-tip wheel at the other end. The linkage may further include at least one link operable to transfer the bi-directional displacement of the drive-train assembly to the suspension arm. The link may include a bell crank member and/or may be resiliently compressible.

Abstract: A power wheelchair is provided having one or more anti-tip wheels for stabilizing the movement of the frame about the drive wheels. An anti-tip wheel is attached to the end of a suspension arm which is pivotally attached to the frame of the wheelchair. A spring resiliently supports the anti-tip wheel in a neutral position relative to the ground upon which the drive wheels of the wheelchair normal ride. A retaining system selectively fixes position of the anti-tip wheels relative to the frame. The retaining system employs a plurality of teeth, with one portion disposed in combination with said suspension arm, and at least one other tooth disposed for engaging said one portion to provide unidirectional retention of the position of said suspension arm relative to the frame. The engagement of the teeth to lock the position of the suspension arm may be responsive to the torque generated by the motor.