Abstract: The disclosure provides a centralized urology operating room control system. The centralized urology operating room control system comprising: therapy consoles selected from a group consisting of a prostate treatment console, a stone treatment console, a tabletop laser therapy console, and an endoscope control console; and a centralized urology control assembly comprising: a housing configured to house at least: a communications console comprising a speaker; a centralized controller, wherein the centralized controller includes a memory storing non-transitory instructions and a hardware processor that is configured to execute the instructions to cause display of a single user interface, via a display, at least for monitoring operation of the therapy consoles; and a power input console configured to provide single-source power to at least the communications console and the centralized controller.

Abstract: Breast securement devices for imaging systems are provided. The securement device can include a breast tray configured to support a patient's breast. In one example, one or more walls extend from the breast tray to receive the patient's breast. In another example, a pair of arms pivotably extend at least partially over the breast tray to receive the patient's breast therebetween. In still another example, a membrane covers the breast tray and the patient's breast and selectively couples to the breast tray via a suction force. In yet another example, a paddle includes a plurality of flexible fingers that contour to the patient's breast, or includes an array of pins that independently slide within of the paddle and contour to the patient's breast, or includes a bladder having non-Newtonian fluid. Additionally or alternatively, a sling may receive the patient's breast and support the breast from below.

Abstract: Breast securement devices for imaging systems are provided. The securement device can include a breast tray configured to support a patient's breast. In one example, one or more walls extend from the breast tray to receive the patient's breast. In another example, a pair of arms pivotably extend at least partially over the breast tray to receive the patient's breast therebetween. In still another example, a membrane covers the breast tray and the patient's breast and selectively couples to the breast tray via a suction force. In yet another example, a paddle includes a plurality of flexible fingers that contour to the patient's breast, or includes an array of pins that independently slide within of the paddle and contour to the patient's breast, or includes a bladder having non-Newtonian fluid. Additionally or alternatively, a sling may receive the patient's breast and support the breast from below.

Abstract: A novel class of inhibitors of ubiquitin isopeptidases is disclosed that cause tumor cell death via molecular mechanisms independent of p53. Specifically, compounds containing an a,?-unsaturated ketone with a sterically accessible electrophilic ?-carbon and related compounds are identified herein. Pharmaceutical compositions comprising the inhibitor compounds and methods of using the compounds for treating a variety of disease states are disclosed.