Patents by Inventor James N. Topper

James N. Topper has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Identification of a family of secreted proteins in vascular endothelium
    Patent number: 8211640
    Abstract: The invention relates to SCUBE molecules and generally to gene expression in vascular endothelial cells. The invention specifically relates to the discovery of a novel gene family containing the genes and proteins referred to herein as SCUBE1, SCUBE2 and SCUBE3 which can be expressed in endothelial cells. SCUBE proteins may be involved in the development of cardiovascular disease, hemostasis, thrombosis, inflammatory disease, bone metabolism disorders, urinary bladder disorders and breast disorders.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: July 3, 2012
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Ruey-Bing Yang, Chi Kin Domingos Ng, James E. Tomlinson, Laszlo G. Komuves, James N. Topper, Keith E. Robison
  • Identification of a family of secreted proteins in vascular endothelium
    Publication number: 20090264361
    Abstract: The invention relates to SCUBE molecules and generally to gene expression in vascular endothelial cells. The invention specifically relates to the discovery of a novel gene family containing the genes and proteins referred to herein as SCUBE1, SCUBE2 and SCUBE3 which can be expressed in endothelial cells. SCUBE proteins may be involved in the development of cardiovascular disease, hemostasis, thrombosis, inflammatory disease, bone metabolism disorders, urinary bladder disorders and breast disorders.
    Type: Application
    Filed: December 18, 2008
    Publication date: October 22, 2009
    Inventors: Ruey-Bing Yang, Chi Kin Domingos Ng, James E. Tomlinson, Laszlo G. Komuves, James N. Topper, Keith E. Robison
  • Identification of a family of secreted proteins in vascular endothelium
    Patent number: 7485431
    Abstract: The invention relates to SCUBE molecules and generally to gene expression in vascular endothelial cells. The invention specifically relates to the discovery of a novel gene family containing the genes and proteins referred to herein as SCUBE1, SCUBE2 and SCUBE3 which can be expressed in endothelial cells. SCUBE proteins may be involved in the development of cardiovascular disease, hemostasis, thrombosis, inflammatory disease, bone metabolism disorders, urinary bladder disorders and breast disorders.
    Type: Grant
    Filed: March 22, 2007
    Date of Patent: February 3, 2009
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Ruey-Bing Yang, Chi Kin Domingos Ng, James E. Tomlinson, Laszlo G. Komuves, James N. Topper, Keith E. Robison
  • Identification of a family of secreted proteins in vascular endothelium
    Patent number: 7258988
    Abstract: The invention relates to SCUBE molecules and generally to gene expression in vascular endothelial cells. The invention specifically relates to the discovery of a novel gene family containing the genes and proteins referred to herein as SCUBE1, SCUBE2 and SCUBE3 which can be expressed in endothelial cells. SCUBE proteins may be involved in the development of cardiovascular disease, hemostasis, thrombosis, inflammatory disease, bone metabolism disorders, urinary bladder disorders and breast disorders.
    Type: Grant
    Filed: April 3, 2003
    Date of Patent: August 21, 2007
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Ruey-Bing Yang, Chi Kin Domingos Ng, James E. Tomlinson, Laszlo G. Komuves, James N. Topper, Keith E. Robison
  • Proteins and nucleic acids encoding same
    Patent number: 6989232
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Grant
    Filed: August 27, 2001
    Date of Patent: January 24, 2006
    Assignees: Millennium Pharmaceuticals, Inc., Curagen Corporation
    Inventors: Catherine E. Burgess, Pamela B. Conley, William M. Grosse, Matthew Hart, Ramesh Kekuda, Richard A. Shimkets, Kimberly A. Spytek, Edward Szekeres, Jr., James E. Tomlinson, James N. Topper, Ruey-Bin Yang
  • Novel proteins and nucleic acids encoding same
    Publication number: 20040039163
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: August 27, 2001
    Publication date: February 26, 2004
    Inventors: Catherine E. Burgess, Pamela B. Conley, William M. Grosse, Matthew Hart, Ramesh Kekuda, Richard A. Shimkets, Kimberly A. Spytek, Edward S. Szekeres, James E. Tomlinson, James N. Topper, Ruey-Bin Yang
  • Identification of a family of secreted proteins in vascular endothelium
    Publication number: 20030219813
    Abstract: The invention relates to SCUBE molecules and generally to gene expression in vascular endothelial cells. The invention specifically relates to the discovery of a novel gene family containing the genes and proteins referred to herein as SCUBE1, SCUBE2 and SCUBE3 which can be expressed in endothelial cells. SCUBE proteins may be involved in the development of cardiovascular disease, hemostasis, thrombosis, inflammatory disease, bone metabolism disorders, urinary bladder disorders and breast disorders.
    Type: Application
    Filed: April 3, 2003
    Publication date: November 27, 2003
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Ruey-Bing Yang, Chi Kin Domingos Ng, James E. Tomlinson, Laszlo G. Komuves, James N. Topper, Keith E. Robison
  • Novel polynucleotides from atherogenic cells and polypeptides encoded thereby
    Publication number: 20020082206
    Abstract: The present invention provides ORFX, a novel isolated polypeptide, as well as a polynucleotide encoding ORFX and antibodies that immunospecifically bind to ORFX or any derivative, variant, mutant, or fragment of the ORFX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the ORFX polypeptide, polynucleotide and antibody are used in detection and treatment of a broad range of pathological states, as well as to others uses.
    Type: Application
    Filed: May 30, 2001
    Publication date: June 27, 2002
    Inventors: Martin D. Leach, Fuad Mehraban, Pamela B. Conley, James N. Topper, Debbie Law