Abstract: The invention features compounds (e.g., macrocyclic compounds) capable of modulating biological processes, for example through binding to a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein (e.g., a eukaryotic target protein such as a mammalian target protein or a fungal target protein or a prokaryotic target protein such as a bacterial target protein). These compounds bind endogenous intracellular presenter proteins, such as the FKBPs or cyclophilins, and the resulting binary complexes selectively bind and modulate the activity of intracellular target proteins. Formation of a tripartite complex among the presenter protein, the compound, and the target protein is driven by both protein-compound and protein-protein interactions, and both are required for modulation of the targeted protein's activity.

Abstract: A phase separated composite glass has a first phase and a second phase. The first phase has an average microstructure size greater than a natural coursing limit of the phase separated composite glass (i.e., outside of what would be achievable by natural phase separation or otherwise in violation of the morphology constraints defined by a liquid-liquid immiscibility dome for the given bulk composition). Methods of preparing a phase separated composite glass based on a phase separated precursor glass or a template glass. Methods include combining a milled first glass corresponding to the first phase and a milled second glass corresponding to the second phase to form a glass mixture. Methods include melting the glass mixture at a temperature from about 25° C. to 0° C. less than an isotherm tie-line between endpoints of a pseudo-binary immiscibility dome defined by the phase separated precursor glass or the template glass.

Abstract: Methods and apparatus are disclosed herein to center a steering wheel. An example vehicle includes a steering assistance system, an axle including a wheel, memory, and a processor to execute instructions to identify a first position of the wheel, detect a request to move the wheel to a second position, adjust the wheel from the first position to the second position via the steering assistance system, disengage the steering assistance system, the disengagement of the steering assistance system to cause the wheel to move to a third position, the third position offset from the second position by an angular offset in a first direction, adjust the wheel to a fourth position, the fourth position offset from the second position by the angular offset in a second direction different than the first direction, and disengage the steering assistance system, the disengagement of the steering assistance system to cause the wheel to move to the second position.

Abstract: Methods and apparatus are disclosed herein to center a steering wheel. An example vehicle includes a steering assistance system, an axle including a wheel, memory, and a processor to execute instructions to identify a first position of the wheel, detect a request to move the wheel to a second position, adjust the wheel from the first position to the second position via the steering assistance system, disengage the steering assistance system, the disengagement of the steering assistance system to cause the wheel to move to a third position, the third position offset from the second position by an angular offset in a first direction, adjust the wheel to a fourth position, the fourth position offset from the second position by the angular offset in a second direction different than the first direction, and disengage the steering assistance system, the disengagement of the steering assistance system to cause the wheel to move to the second position.

Abstract: Methods and apparatus are disclosed herein to center a steering wheel. An example vehicle includes a steering position sensor to identify a steering wheel position, a pinion angle identifier to compare a first steering position angle to a second steering position angle, the second steering position angle corresponding to a centered steering wheel position, and an angle modifier to adjust the first steering position angle to match the second steering position angle.

Abstract: Improved methods for generating a virtual representation of an interior space such as a room are provided. Techniques for capturing and normalizing sets of points for polygon mesh generation that utilize augmented reality toolkits are also described. The improved methods comprise: techniques for generating a polygon mesh that incorporates a projecting extrusion; techniques for generating a polygon mesh that incorporates curved surfaces; and techniques for generating a polygon mesh in real-time.

Abstract: Methods, computer systems and computer programs for generating a virtual representation of an interior space such as a room are provided. Techniques for capturing and normalizing sets of points for polygon mesh generation that utilize augmented reality toolkits are also described.

Abstract: An orchard sanitation implement disposes of unharvested nuts which may otherwise be utilized as habitat and food for navel orangeworms. Unharvested nuts are lifted from the orchard floor and delivered to a storage bin of the implement. Once received within the storage bin, the unharvested nuts are separated from other orchard debris by a looping belt which allows unharvested nuts to fall through, but other orchard debris is conveyed outside of the storage bin for deposit either into a container or back to the orchard floor. The unharvested nuts fall through openings in the looping belt, through an outlet at the bottom of the storage bin and into a shredding unit attached to the outlet. The shredding unit shreds and pulverizes the unharvested nuts into a composition which is too small to be utilized by navel orangeworms for habitat or a source of food.

Abstract: A seal includes a mating ring that rotates relative to a carbon primary ring at a seal interface. A buffer gas is provided into the seal and passes from the back of the primary ring to the seal interface. The seal can be used as a separation seal or in combination with another seal.

Abstract: An orchard sanitation implement disposes of unharvested nuts which may otherwise be utilized as habitat and food for navel orangeworms. Unharvested nuts are lifted from the orchard floor and delivered to a storage bin of the implement. Once received within the storage bin, the unharvested nuts are separated from other orchard debris by a looping belt which allows unharvested nuts to fall through, but other orchard debris is conveyed outside of the storage bin for deposit either into a container or back to the orchard floor. The unharvested nuts fall through openings in the looping belt, through an outlet at the bottom of the storage bin and into a shredding unit attached to the outlet. The shredding unit shreds and pulverizes the unharvested nuts into a composition which is too small to be utilized by navel orangeworms for habitat or a source of food.

Abstract: An orchard sanitation implement disposes of unharvested nuts which may otherwise be utilized as habitat and food for navel orangeworms. Unharvested nuts are lifted from the orchard floor and delivered to a storage bin of the implement. Once received within the storage bin, the unharvested nuts are separated from other orchard debris by a looping belt which allows unharvested nuts to fall through, but other orchard debris is conveyed outside of the storage bin for deposit either into a container or back to the orchard floor. The unharvested nuts fall through openings in the looping belt, through an outlet at the bottom of the storage bin and into a shredding unit attached to the outlet. The shredding unit shreds and pulverizes the unharvested nuts into a composition which is too small to be utilized by navel orangeworms for habitat or a source of food.

Abstract: A seal includes a mating ring that rotates relative to a porous carbon primary ring at a seal interface. A buffer gas is provided into the seal and passes from the back of the primary ring to the seal interface. The seal can be used as a separation seal or in combination with another seal.

Abstract: Described herein are compositions and methods for the treatment or prevention of ocular surface disorders including meibomian gland dysfunction, blepharitis, dry eye disease and other inflammatory and/or infectious diseases of the anterior surface of the eye(s). Said compositions and methods comprise keratolytic conjugates which demonstrate keratolytic activity, and anti-inflammatory or other desirable activities. Topical administration of said compositions to the eyelid margin or surrounding areas provides therapeutic benefit to patients suffering from ocular surface disorders.

Abstract: A seal includes a mating ring that rotates relative to a carbon primary ring at a seal interface. A buffer gas is provided into the seal and passes from the back of the primary ring to the seal interface. The seal can be used as a separation seal or in combination with another seal.

Abstract: Methods and apparatus are disclosed herein to center a steering wheel. An example vehicle includes a steering position sensor to identify a steering wheel position, a pinion angle identifier to compare a first steering position angle to a second steering position angle, the second steering position angle corresponding to a centered steering wheel position, and an angle modifier to adjust the first steering position angle to match the second steering position angle.

Abstract: Methods and apparatus are disclosed herein to center a steering wheel. An example vehicle includes a steering assistance system, an axle including a wheel, memory, and a processor to execute instructions to identify a first position of the wheel, detect a request to move the wheel to a second position, adjust the wheel from the first position to the second position via the steering assistance system, disengage the steering assistance system, the disengagement of the steering assistance system to cause the wheel to move to a third position, the third position offset from the second position by an angular offset in a first direction, adjust the wheel to a fourth position, the fourth position offset from the second position by the angular offset in a second direction different than the first direction, and disengage the steering assistance system, the disengagement of the steering assistance system to cause the wheel to move to the second position..

Abstract: An orchard sanitation implement disposes of unharvested nuts which may otherwise be utilized as habitat and food for navel orangeworms. Unharvested nuts are lifted from the orchard floor and delivered to a storage bin of the implement. Once received within the storage bin, the unharvested nuts are separated from other orchard debris by a looping belt which allows unharvested nuts to fall through, but other orchard debris is conveyed outside of the storage bin for deposit either into a container or back to the orchard floor. The unharvested nuts fall through openings in the looping belt, through an outlet at the bottom of the storage bin and into a shredding unit attached to the outlet. The shredding unit shreds and pulverizes the unharvested nuts into a composition which is too small to be utilized by navel orangeworms for habitat or a source of food.

Abstract: A seal includes a mating ring that rotates relative to a porous carbon primary ring at a seal interface. A buffer gas is provided into the seal and passes from the back of the primary ring to the seal interface. The seal can be used as a separation seal or in combination with another seal.

Abstract: Methods, computer systems and computer programs for generating a virtual representation of an interior space such as a room are provided. Techniques for capturing and normalizing sets of points for polygon mesh generation that utilize augmented reality toolkits are also described.