Patents by Inventor James Nieman
James Nieman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240059649Abstract: Novel substituted N-acetyl-L-cysteine (NAC) derivatives and related compounds and methods of using these compounds for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.Type: ApplicationFiled: October 17, 2023Publication date: February 22, 2024Applicant: Promentis Pharmaceuticals, Inc.Inventors: Michael Neary, James Nieman, Steven Tanis, Daniel Lawton, Garry Smith
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Publication number: 20230136702Abstract: Provided herein are compounds, compositions and methods for inhibition of herpesviruses. In some cases, the subject compounds inhibit a herpesvirus in a cell. Also provided are compounds, compositions and methods for treating a herpesvirus in an individual. In some cases, the methods include administering to an individual a therapeutically effective amount of a subject compound to treat the individual for the herpesvirus. In certain embodiments, the compounds disclosed herein are cytomegalovirus (CMV) inhibitors. In certain embodiments, the compounds disclosed herein are human cytomegalovirus (CMV) inhibitors.Type: ApplicationFiled: March 2, 2021Publication date: May 4, 2023Inventors: James Nieman, Mostofa Hena, Bing Bai, Appan Srinivas Kandadai, Alexandr Belovodskiy
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Publication number: 20210395194Abstract: Novel substituted N-acetyl-L-cysteine (NAC) derivatives and related compounds and methods of using these compounds for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.Type: ApplicationFiled: March 29, 2021Publication date: December 23, 2021Applicant: Promentis Pharmaceuticals, Inc.Inventors: Michael Neary, James Nieman, Steven Tanis, Daniel Lawton, Garry Smith
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Patent number: 10961187Abstract: Novel substituted N-acetyl-L-cysteine (NAC) derivatives and related compounds and methods of using these compounds for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.Type: GrantFiled: June 17, 2019Date of Patent: March 30, 2021Assignee: Promentis Pharmaceuticals, Inc.Inventors: Michael Neary, James Nieman, Steven Tanis, Daniel Lawton, Garry Smith
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Publication number: 20190315683Abstract: Novel substituted N-acetyl-L-cysteine (NAC) derivatives and related compounds and methods of using these compounds for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.Type: ApplicationFiled: June 17, 2019Publication date: October 17, 2019Applicant: Promentis Pharmaceuticals, Inc.Inventors: Michael Neary, James Nieman, Steven Tanis, Daniel Lawton, Garry Smith
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Patent number: 10358414Abstract: Novel substituted N-acetyl-L-cysteine (NAC) derivatives and related compounds and methods of using these compounds for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers? disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.Type: GrantFiled: April 7, 2017Date of Patent: July 23, 2019Assignee: Promentis Pharmaceuticals, Inc.Inventors: Michael Neary, James Nieman, Steven Tanis, Daniel Lawton, Garry Smith
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Patent number: 10112897Abstract: Novel substituted N-acetyl-L-cysteine (NAC) derivatives and related compounds and methods of using these compounds for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.Type: GrantFiled: March 15, 2017Date of Patent: October 30, 2018Assignee: Promentis Pharmaceuticals, Inc.Inventors: Michael Neary, James Nieman, Steven Tanis, Daniel Lawton
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Publication number: 20170210716Abstract: Novel substituted N-acetyl-L-cysteine (NAC) derivatives and related compounds and methods of using these compounds for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers? disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.Type: ApplicationFiled: April 7, 2017Publication date: July 27, 2017Applicant: Promentis Pharmaceuticals, Inc.Inventors: Michael Neary, James Nieman, Steven Tanis, Daniel Lawton, Garry Smith
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Publication number: 20170183303Abstract: Novel substituted N-acetyl-L-cysteine (NAC) derivatives and related compounds and methods of using these compounds for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.Type: ApplicationFiled: March 15, 2017Publication date: June 29, 2017Applicant: Promentis Pharmaceuticals, Inc.Inventors: Michael Neary, James Nieman, Steven Tanis, Daniel Lawton
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Patent number: 9630937Abstract: Novel substituted N-acetyl-L-cysteine (NAC) derivatives and related compounds and methods of using these compounds for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.Type: GrantFiled: November 7, 2014Date of Patent: April 25, 2017Assignee: Promentis Pharmaceuticals, Inc.Inventors: Michael Neary, James Nieman, Steven Tanis, Daniel Lawton, Garry Smith
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Publication number: 20150133470Abstract: Novel substituted N-acetyl-L-cysteine (NAC) derivatives and related compounds and methods of using these compounds for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.Type: ApplicationFiled: November 7, 2014Publication date: May 14, 2015Inventors: Michael Neary, James Nieman, Steven Tanis, Daniel Lawton, Garry Smith
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Publication number: 20150133544Abstract: A novel substituted N-acetyl-L-cysteine (NAC) derivative and methods of using this compound for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.Type: ApplicationFiled: November 7, 2014Publication date: May 14, 2015Inventors: Michael Neary, James Nieman, Steven Tanis, Daniel Lawton
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Patent number: 9012674Abstract: A novel substituted N-acetyl-L-cysteine (NAC) derivative and methods of using this compound for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.Type: GrantFiled: November 7, 2014Date of Patent: April 21, 2015Assignee: Promentis Pharmaceuticals, Inc.Inventors: Michael Neary, James Nieman, Steven Tanis, Daniel Lawton
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Publication number: 20090264487Abstract: This invention provides analogs of hemiasterlin, methods of synthesis of the analogs and use of the analogs as a cytotoxic anti-mitotic agents.Type: ApplicationFiled: June 25, 2009Publication date: October 22, 2009Applicant: THE UNIVERSITY OF BRITISH COLUMBIAInventors: Raymond ANDERSEN, Edward Piers, James Nieman, John Coleman, Michel Roberge
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Patent number: 7579323Abstract: This invention provides analogs of hemiasterlin, methods of synthesis of the analogs and use of the analogs as cytotoxic and anti-mitotic agents.Type: GrantFiled: December 13, 1998Date of Patent: August 25, 2009Assignee: The University of British ColumbiaInventors: Raymond Andersen, Edward Piers, James Nieman, John Coleman, Michel Roberge
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Publication number: 20060079533Abstract: Disclosed are methods for treating Alzheimer's disease, and other diseases, and/or inhibiting beta-secretase enzyme, and/or inhibiting deposition of A beta peptide in a mammal, by use of 3,4-disubstituted piperidinyl compounds of formula (I) wherein the variables R1, R2, R3, R4, Q, W, X, Z, m, and n are defined herein.Type: ApplicationFiled: March 21, 2002Publication date: April 13, 2006Inventors: James Nieman, Lawrence Fang, barbara Jagodzinska