Patents by Inventor James Nieman

James Nieman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cysteine prodrugs
    Patent number: 9457014
    Abstract: Novel cysteine prodrugs and their use in the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of the Central Nervous System (CNS), including but not limited to schizophrenia, drug craving, drug addiction, bipolar disorder, anxiety, depression, Parkinson's disease, Alzheimer's disease, cognitive dysfunction, multiple sclerosis, Amyotrophic lateral sclerosis (ALS), ischemic stroke, HIV dementia, and Huntington's disease.
    Type: Grant
    Filed: July 30, 2012
    Date of Patent: October 4, 2016
    Assignee: Promentis Pharmaceuticals, Inc.
    Inventors: Daniel Lawton, Michael Neary, James A. Nieman
  • Cysteine Prodrugs
    Publication number: 20160081987
    Abstract: Novel cysteine prodrugs and their use in the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of the Central Nervous System (CNS), including but not limited to schizophrenia, drug craving, drug addiction, bipolar disorder, anxiety, depression, Parkinson's disease, Alzheimer's disease, cognitive dysfunction, multiple sclerosis, Amyotrophic lateral sclerosis (ALS), ischemic stroke, HIV dementia, and Huntington's disease.
    Type: Application
    Filed: July 30, 2012
    Publication date: March 24, 2016
    Applicant: PROMENTIS PHARMACEUTICALS, INC.
    Inventors: Daniel Lawton, Michael Neary, James A. Nieman
  • BORON-CONTAINING SMALL MOLECULES
    Publication number: 20150133402
    Abstract: This invention provides, among other things, novel compounds useful for treating bacterial infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
    Type: Application
    Filed: November 7, 2014
    Publication date: May 14, 2015
    Inventors: STEPHEN J. BAKER, VINCENT S. HERNANDEZ, RASHMI SHARMA, JAMES A. NIEMAN, TSUTOMU AKAMA, YONG-KANG ZHANG, JACOB J. PLATTNER, MICHAEL RICHARD KEVIN ALLEY, RAJESHWAR SINGH, FERNANDO ROCK
  • ETHYL (2R)-2-ACETAMIDO-3-(4-METHYLBENZOYLSULFANYL)PROPANOATE AND USES THEREOF
    Publication number: 20150133544
    Abstract: A novel substituted N-acetyl-L-cysteine (NAC) derivative and methods of using this compound for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.
    Type: Application
    Filed: November 7, 2014
    Publication date: May 14, 2015
    Inventors: Michael Neary, James Nieman, Steven Tanis, Daniel Lawton
  • SUBSTITUTED N-ACETYL-L-CYSTEINE DERIVATIVES AND RELATED COMPOUNDS
    Publication number: 20150133470
    Abstract: Novel substituted N-acetyl-L-cysteine (NAC) derivatives and related compounds and methods of using these compounds for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.
    Type: Application
    Filed: November 7, 2014
    Publication date: May 14, 2015
    Inventors: Michael Neary, James Nieman, Steven Tanis, Daniel Lawton, Garry Smith
  • Ethyl (2R)-2-acetamido-3-(4-methylbenzoylsulfanyl)propanoate and uses thereof
    Patent number: 9012674
    Abstract: A novel substituted N-acetyl-L-cysteine (NAC) derivative and methods of using this compound for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: April 21, 2015
    Assignee: Promentis Pharmaceuticals, Inc.
    Inventors: Michael Neary, James Nieman, Steven Tanis, Daniel Lawton
  • Boron containing small molecules
    Patent number: 8895534
    Abstract: Novel monosubstituted and disubstutituted oxaboroles and pharmaceutical compositions containing such oxaboroles are provided, which are useful for treating bacterial infections, as well as combinations of these oxaboroles with at least one additional therapeutically effective agent.
    Type: Grant
    Filed: July 30, 2010
    Date of Patent: November 25, 2014
    Assignee: Anacor Pharmaceuticals, Inc.
    Inventors: Stephen J. Baker, Vincent S. Hernandez, Rashmi Sharma, James A. Nieman, Tsutomu Akama, Yong-Kang Zhang, Jacob J. Plattner, Michael Richard Kevin Alley, Rajeshwar Singh, Fernando Rock
  • BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS
    Publication number: 20140011768
    Abstract: Compounds and methods of treating anti-inflammatory conditions are disclosed.
    Type: Application
    Filed: June 11, 2013
    Publication date: January 9, 2014
    Inventors: Tsutomu Akama, Yong-Kang Zhang, Charles Z. Ding, Jacob J. Plattner, Kirk R. Maples, Yvonne Freund, Virginia Sanders, Yi Xia, Stephen J. Baker, James A. Nieman, Xiaosong Lu, Marcelo Sales, Rashmi Sharma, Rajeshwar Singh, Robert Jacobs, Daitao Chen, Michael Richard Kevin Alley
  • Boron-containing small molecules
    Patent number: 8461134
    Abstract: This invention relates to, among other items, 6-substituted benzoxaborole compounds and their use for treating bacterial infections.
    Type: Grant
    Filed: November 11, 2010
    Date of Patent: June 11, 2013
    Assignee: Anacor Pharmaceuticals, Inc.
    Inventors: Vincent S. Hernandez, Xianfeng Li, Suoming Zhang, Tsutomu Akama, Yanchen Zhang, Yang Liu, Jacob J. Plattner, Michael Richard Kevin Alley, Yasheen Zhou, James A. Nieman
  • Boron-containing small molecules as anti-inflammatory agents
    Patent number: 8461135
    Abstract: Compounds and methods of treating anti-inflammatory conditions are disclosed.
    Type: Grant
    Filed: September 19, 2011
    Date of Patent: June 11, 2013
    Assignee: Anacor Pharmaceuticals, Inc.
    Inventors: Tsutomu Akama, Yong-Kang Zhang, Charles Z. Ding, Jacob J. Plattner, Kirk R. Maples, Yvonne Freund, Virginia Sanders, Yi Xia, Stephen J. Baker, James A. Nieman, Xiaosong Lu, Marcelo Sales, Rashmi Sharma, Rajeshwar Singh, Robert T. Jacobs, Daitao Chen, Michael Richard Kevin Alley
  • BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS
    Publication number: 20120214765
    Abstract: Compounds and methods of treating anti-inflammatory conditions are disclosed.
    Type: Application
    Filed: September 19, 2011
    Publication date: August 23, 2012
    Applicant: Anacor Pharmaceuticals, Inc.
    Inventors: Tsutomu Akama, Yong-Kang Zhang, Charles Z. Ding, Jacob J. Plattner, Kirk R. Maples, Yvonne Freund, Virginia Sanders, Yi Xia, Stephen J. Baker, James A. Nieman, Xiaosong Lu, Marcelo Sales, Rashmi Sharma, Rajeshwar Singh, Robert T. Jacobs, Daitao Chen, Michael Richard Kevin Alley
  • Boron-containing small molecules as anti-inflammatory agents
    Patent number: 8039450
    Abstract: Compounds and methods of treating anti-inflammatory conditions are disclosed.
    Type: Grant
    Filed: March 5, 2009
    Date of Patent: October 18, 2011
    Assignee: Anacor Pharmaceuticals, Inc.
    Inventors: Tsutomu Akama, Yong-Kang Zhang, Charles Z. Ding, Jacob J. Plattner, Kirk R. Maples, Yvonne Freund, Virginia Sanders, Yi Xia, Stephen J. Baker, James A. Nieman, Xiaosong Lu, Marcelo Sales, Rashmi Sharma, Rajeshwar Singh, Robert Jacobs, Daitao Chen, Michael Richard Kevin Alley
  • BORON-CONTAINING SMALL MOLECULES
    Publication number: 20110212918
    Abstract: This invention relates to, among other items, 6-substituted benzoxaborole compounds and their use for treating bacterial infections.
    Type: Application
    Filed: November 11, 2010
    Publication date: September 1, 2011
    Applicant: Anacor Pharmaceuticals, Inc.
    Inventors: Vincent S. Hernandez, Xianfeng Li, Suoming Zhang, Tsutomu Akama, Yanchen Zhang, Yang Liu, Jacob J. Plattner, Michael Richard Kevin Alley, Yasheen Zhou, James A. Nieman
  • BORON-CONTAINING SMALL MOLECULES
    Publication number: 20110172187
    Abstract: This invention relates to, among other items, 6-substituted benzoxaborole compounds and their use for treating bacterial infections.
    Type: Application
    Filed: November 11, 2010
    Publication date: July 14, 2011
    Applicant: Anacor Pharmaceuticals, Inc.
    Inventors: Vincent S. HERNANDEZ, Xiangeng Li, Suoming ZHANG, Tsutomu AKAMA, Yanchen ZHANG, Yang LIU, Jacob J. PLATTNER, Michael Richard Kevin ALLEY, Yasheen ZHOU, James A. NIEMAN
  • BORON-CONTAINING SMALL MOLECULES
    Publication number: 20100292504
    Abstract: This invention provides, among other things, novel compounds useful for treating bacterial infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
    Type: Application
    Filed: July 30, 2010
    Publication date: November 18, 2010
    Applicant: Anacor Pharmaceuticals, Inc.
    Inventors: Stephen J. Baker, Vincent S. Hernandez, Rashmi Sharma, James A. Nieman, Tsutomu Akama, Yong-Kang Zhang, Jacob J. Plattner, Michael Richard Kevin Alley, Rajeshwar Singh, Fernando Rock
  • Boron-containing small molecules
    Patent number: 7816344
    Abstract: This invention provides, among other things, novel oxaboroles which are monosubstituted at the 3-, 6-, or 7-position, or disubstituted at the 3-/6- or 3-/7- positions, which are useful for treating bacterial infections, pharmaceutical compositions containing such oxaboroles, as well as combinations of these oxaboroles with at least one additional therapeutically effective agent.
    Type: Grant
    Filed: June 19, 2008
    Date of Patent: October 19, 2010
    Assignee: Anacor Pharmaceuticals, Inc.
    Inventors: Stephen J. Baker, Vincent S. Hernandez, Rashmi Sharma, James A. Nieman, Tsutomu Akama, Yong-Kang Zhang, Jacob J. Plattner, Michael Richard Kevin Alley, Rajeshwar Singh, Fernando Rock
  • BORON-CONTAINING SMALL MOLECULES
    Publication number: 20100256092
    Abstract: This invention relates to, among other items, 6-substituted benzoxaborole compounds and their use for treating bacterial infections.
    Type: Application
    Filed: May 12, 2009
    Publication date: October 7, 2010
    Applicants: Anacor Pharmaceuticals, Inc., GlaxoSmithKline
    Inventors: Yi Xia, Michael Richard Kevin Alley, Yasheen Zhou, Vincent S. Hernandez, Jacob J. Plattner, Charles Z. Ding, Kathy Cao, Yong-Kang Zhang, Andrew Benowitz, Tsutomu Akama, Jessica Sligar, Guofeng Jia, Ligong Ou, Neerja Saraswat, Sreekanth Ramachandran, Chris Diaper, Yanchen Zhang, Goverdhan Reddy Banda, James A. Nieman, Mehdi Keramane, Rahim Mohammed, Rajendra Subedi, Hong Liang, Rajeshwar Singh
  • Boron-Containing Small Molecules as Anti-Inflammatory Agents
    Publication number: 20090291917
    Abstract: Compounds and methods of treating anti-inflammatory conditions are disclosed.
    Type: Application
    Filed: March 5, 2009
    Publication date: November 26, 2009
    Applicant: Anacor Pharmaceuticals, Inc.
    Inventors: Tsutomu Akama, Yong-Kang Zhang, Charles Z. Ding, Jacob J. Plattner, Kirk R. Maples, Yvonne Freund, Virginia Sanders, Yi Xia, Stephen J. Baker, James A. Nieman, Xiaosong Lu, Marcelo Sales, Rashmi Sharma, Rajeshwar Singh, Robert T. Jacobs, Daitao Chen, Michael Richard Kevin Alley
  • HEMIASTERLIN ANALOGS
    Publication number: 20090264487
    Abstract: This invention provides analogs of hemiasterlin, methods of synthesis of the analogs and use of the analogs as a cytotoxic anti-mitotic agents.
    Type: Application
    Filed: June 25, 2009
    Publication date: October 22, 2009
    Applicant: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Raymond ANDERSEN, Edward Piers, James Nieman, John Coleman, Michel Roberge
  • BORON-CONTAINING SMALL MOLECULES
    Publication number: 20090227541
    Abstract: This invention provides, among other things, novel compounds useful for treating bacterial infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
    Type: Application
    Filed: June 19, 2008
    Publication date: September 10, 2009
    Applicant: Anacor Pharmaceuticals, Inc.
    Inventors: Stephen J. Baker, Vincent S. Hernandez, Rashmi Sharma, James A. Nieman, Tsutomu Akama, Yong-Kang Zhang, Jacob J. Plattner, Michael Richard Kevin Alley, Rajeshwar Singh, Fernando Rock